Cocooning Wound for Healing
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Wound
healing
is
highly
sensitive
to
environmental
conditions.
Under
solar
radiation,
elevated
wound
temperatures
and
UV-rays
can
induce
oxidative
stress,
disrupt
the
environment,
provoke
inflammation,
even
cause
thermal
injury.
Lower
may
hinder
angiogenesis
immune
function,
thus
delaying
recovery.
Inspired
by
silkworm
cocooning
for
comfort
during
metamorphosis,
we
developed
cocoon
(W-cocoon)
using
a
portable
high-speed
electro-blow
spinning
(EBS)
device.
The
W-cocoon
integrates
radiative
cooling
insulation
properties,
providing
both
(3.9
°C)
under
sunlight
warming
(1.9
indoors.
Based
on
animal
studies,
promotes
recovery
in
indoor
scenarios,
while
its
high
reflectivity
UV-blocking
ratio
mitigate
negative
effects
of
optimizing
healing.
Additionally,
exhibits
superhydrophobic
hemophobic
which
endow
dressing
with
antifouling
capabilities
reduce
pain
changes.
Язык: Английский
Dynamic GelMA/DNA Dual‐Network Hydrogels Promote Woven Bone Organoid Formation and Enhance Bone Regeneration
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
Abstract
Bone
organoids,
in
vitro
models
mimicking
native
bone
structure
and
function,
rely
on
3D
stem
cell
culture
for
self‐organization,
differentiation,
ECM
secretion,
biomineralization,
ultimately
forming
mineralized
collagen
hierarchies.
However,
their
development
is
often
limited
by
the
lack
of
suitable
matrices
with
optimal
mechanical
properties
sustained
growth
differentiation.
To
address
this,
a
dynamic
DNA/Gelatin
methacryloyl
(GelMA)
hydrogel
(CGDE)
developed
to
recapitulate
key
biochemical
features
ECM,
providing
supportive
microenvironment
organoid
formation.
This
dual‐network
engineered
through
hydrogen
bonding
between
DNA
GelMA,
combined
GelMA
network
crosslinking,
resulting
appropriate
strength
enhanced
viscoelasticity.
During
21‐day
culture,
CGDE
facilitates
cellular
migration
promoting
woven
(WBO)
formation
via
intramembranous
ossification.
These
WBOs
exhibit
spatiotemporal
architectures
supporting
mineralization
tissue
remodeling.
In
vivo
studies
demonstrate
that
CGDE‐derived
self‐adaptive
properties,
enabling
rapid
osseointegration
within
4
weeks.
work
highlights
as
robust
scalable
platform
development,
offering
new
insights
into
biology
innovative
strategies
regeneration.
Язык: Английский
Mucus-Inspired Supramolecular Adhesives: Exploring the Synergy between Dynamic Networks and Functional Liquids
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
The
exceptional
physicochemical
and
mechanical
properties
of
mucus
have
inspired
the
development
dynamic
mucus-based
materials
for
a
wide
range
applications.
Mucus's
combination
noncovalent
interactions
rich
liquid
phases
confer
properties.
This
perspective
explores
synergy
between
networks
functional
liquids
in
mucus-inspired
supramolecular
adhesives.
It
delves
into
biological
principles
underlying
mucus's
regulation
adhesive
properties,
fundamentals
design,
transformative
potential
these
biomedical
Finally,
this
proposes
directions
molecular
engineering
materials,
emphasizing
need
interdisciplinary
approaches
to
harness
their
full
sustainable
Язык: Английский