Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Small, Год журнала: 2018, Номер 15(1)

Опубликована: Ноя. 20, 2018

Abstract Phototherapy including photothermal therapy (PTT) and photodynamic (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional include easy recognition immune system, rapid clearance from blood circulation, low accumulation in target sites. Cell‐membrane coating emerged as a potential way overcome these limitations, owing abundant proteins on surface of cell membranes that can be inherited membrane–camouflaged nanoparticles. This review summarizes recent advances development biomimetic nanoparticles phototherapy. Different sources used coat uisng different approaches. After cell‐membrane coating, photophysical properties original remain nearly unchanged; however, coated are equipped with additional physiological features escape, vivo prolonged circulation time, homologous targeting, depending sources. Moreover, membrane ablated under laser irradiation, leading drug release thus synergetic By combining other supplementary normalize tumor microenvironment, further enhance therapeutic efficacy against cancer.

Язык: Английский

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Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy

Science Advances, Год журнала: 2019, Номер 5(10)

Опубликована: Окт. 11, 2019

Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen system based on the nanoerythrosomes derived from RBCs, inspired by splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto fusing tumor membrane-associated with nanoerythrosomes. This antigen-loaded (nano-Ag@erythrosome) elicited responses in vivo and, combination anti-programmed death ligand 1 (PD-L1) blockade, inhibited growth B16F10 and 4T1 models. We also generated model showing that "personalized nano-Ag@erythrosomes" could be achieved RBCs surgically removed tumors, which effectively reduced recurrence metastasis after surgery.

Язык: Английский

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Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

Advanced Science, Год журнала: 2019, Номер 6(12)

Опубликована: Апрель 24, 2019

Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one most common forms disease, characterized by a gradual formation atherosclerotic plaque, hardening, and narrowing arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy substantially limited in vivo due to nonspecific clearance mononuclear phagocytic system. In order address this limitation, rapamycin (RAP)-loaded poly(lactic-

Язык: Английский

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Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia

Biomaterials, Год журнала: 2019, Номер 228, С. 119578 - 119578

Опубликована: Окт. 29, 2019

Язык: Английский

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Multifunctional antimicrobial materials: From rational design to biomedical applications

Progress in Materials Science, Год журнала: 2021, Номер 125, С. 100887 - 100887

Опубликована: Ноя. 11, 2021

Язык: Английский

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Advances in drug delivery for post-surgical cancer treatment

Biomaterials, Год журнала: 2019, Номер 219, С. 119182 - 119182

Опубликована: Апрель 28, 2019

Язык: Английский

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Engineering of magnetic nanoparticles as magnetic particle imaging tracers

Chemical Society Reviews, Год журнала: 2021, Номер 50(14), С. 8102 - 8146

Опубликована: Янв. 1, 2021

Magnetic particle imaging (MPI) has recently emerged as a promising non-invasive technique. Engineering of magnetic nanoparticles (MNPs) is effective ways to enhance MPI sensitivity and spatial resolution.

Язык: Английский

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Applications of carrier erythrocytes in delivery of biopharmaceuticals

Journal of Controlled Release, Год журнала: 2006, Номер 118(2), С. 145 - 160

Опубликована: Дек. 16, 2006

Язык: Английский

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Biomechano‐Interactive Materials and Interfaces

Advanced Materials, Год журнала: 2018, Номер 30(31)

Опубликована: Июнь 7, 2018

The reciprocal mechanical interaction of engineered materials with biointerfaces have long been observed and exploited in biomedical applications. It contributes to the rise biomechano-responsive biomechano-stimulatory materials, constituting biomechano-interactive interfaces. Here, endogenous exogenous biomechanical stimuli available for mechanoresponsive interfaces are briefed their mechanistic responses, including deformation volume change, mechanomanipulation physical chemical bonds, dissociation assemblies, coupling thermoresponsiveness summarized. mechanostimulatory however, capable delivering cues, stiffness, viscoelasticity, geometrical constraints, loads, modulate physiological pathological behaviors living tissues through adaptive cellular mechanotransduction. widely implemented such fields as mechanotriggered therapeutics diagnosis, biophysical sensors, biointegrated soft actuators, mechanorobust tissue engineering, which offered unprecedented opportunities precision personalized medicine. Pending challenges also addressed shed a light on future advances respect translational implementations.

Язык: Английский

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Biomimetic fibrin-targeted and H2O2-responsive nanocarriers for thrombus therapy

Nano Today, Год журнала: 2020, Номер 35, С. 100986 - 100986

Опубликована: Окт. 4, 2020

Язык: Английский

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