Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

Advanced Materials, Год журнала: 2020, Номер 32(40)

Опубликована: Авг. 28, 2020

Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can phagocytose tumor cells, while anti-inflammatory M2 such as tumor-associated (TAMs) promote growth invasion. Modulating the immune microenvironment through engineering is efficacious therapy. target cancerous cells and, therefore, be used drug carriers for Herein, strategies to engineer immunotherapy, inhibition of macrophage recruitment, depletion TAMs, reprograming blocking CD47-SIRPα pathway, are discussed. Further, recent advances delivery using macrophages, macrophage-derived exosomes, macrophage-membrane-coated nanoparticles elaborated. Overall, there still significant room macrophage-mediated modulation delivery, which will further enhance current therapies against various malignant solid tumors, including drug-resistant tumors metastatic tumors.

Язык: Английский

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Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging

Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(29), С. 11717 - 11731

Опубликована: Март 5, 2020

Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence biological tissue between 650-900 nm, conventional optical often has poor signal-to-background ratio shallow penetration depth, which limits its ability deep-tissue vivo imaging. Second near-infrared fluorescence, chemiluminescence, photoacoustic modalities mitigate these issues by their respective advantages of minimized scattering, eliminated external excitation, ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the change second or signals response biomarker have been developed. This Minireview summarizes design strategies, sensing mechanisms, applications AMPs. The potential challenges perspectives AMPs are also discussed.

Язык: Английский

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Advanced Materials, Год журнала: 2020, Номер 32(10)

Опубликована: Янв. 28, 2020

Abstract Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO 2 , MnO, Mn O 3 4 x ) their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, representative progresses MONs synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, are mainly introduced. First, five kinds primary synthetic methods presented, thermal decomposition method, exfoliation strategy, permanganates reduction adsorption–oxidation hydro/solvothermal. Second, preparations hollow composite materials summarized specially. Then, chemical toxicity discussed. Next, diagnostic imaging sensing outlined. Finally, some rational designs photodynamic therapy, photothermal chemodynamic sonodynamic radiotherapy, magnetic hyperthermia, chemotherapy, gene starvation ferroptosis, immunotherapy, various combination highlighted.

Язык: Английский

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Smart nanoparticles for cancer therapy

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Ноя. 3, 2023

Abstract Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading innovative developments in smart nanoparticles safer more effective therapy. In this review, we will highlight recent advancements including polymeric dendrimers, micelles, liposomes, protein cell membrane mesoporous silica gold iron oxide quantum dots, carbon nanotubes, black phosphorus, MOF others. We focus on their classification, structures, synthesis, intelligent features. These possess the ability various external internal stimuli, such enzymes, pH, temperature, optics, magnetism, making them systems. Additionally, review explore latest studies tumor targeting functionalizing surfaces with tumor-specific ligands like antibodies, peptides, transferrin, folic acid. also summarize different types options, small molecules, proteins, nucleic acids, even living cells, potential use While is promising, acknowledge challenges clinical prospects associated use. Finally, propose blueprint that involves artificial intelligence-powered treatment applications. By harnessing aims usher new era personalized therapy, providing patients individualized options.

Язык: Английский

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Platelet Membrane‐Camouflaged Magnetic Nanoparticles for Ferroptosis‐Enhanced Cancer Immunotherapy

Small, Год журнала: 2020, Номер 16(22)

Опубликована: Апрель 27, 2020

Abstract Although cancer immunotherapy has emerged as a tremendously promising therapy method, it remains effective only for several cancers. Photoimmunotherapy (e.g., photodynamic/photothermal therapy) could synergistically enhance the immune response of immunotherapy. However, excessively generated immunogenicity will cause serious inflammatory syndrome. Herein, biomimetic magnetic nanoparticles, Fe 3 O 4 ‐SAS @ PLT, are reported novel approach to sensitize ferroptosis and generate mild immunogenicity, enhancing rate non‐inflamed tumors ‐SAS@PLT built from sulfasalazine (SAS)‐loaded mesoporous nanoparticles (Fe ) platelet (PLT) membrane camouflage triggered ferroptotic cell death via inhibiting glutamate‐cystine antiporter system X c − pathway. PLT‐mediated significantly improves efficacy programmed 1 checkpoint blockade achieves continuous tumor elimination in mouse model 4T1 metastatic tumors. Proteomics studies reveal that not induce tumor‐specific but also efficiently repolarize macrophages immunosuppressive M2 phenotype antitumor M1 phenotype. Therefore, concomitant with expected provide great potential clinical treatment metastasis.

Язык: Английский

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Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small, Год журнала: 2021, Номер 17(12)

Опубликована: Фев. 12, 2021

Abstract Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, rapid clearance the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed solve these issues. For example, macrophage or neutrophil membrane coated NPs developed with ability interact tumor tissue suppress cancer progression metastasis. The functionality particles largely depends on surface proteins cells their preserved function during extraction coating process NPs. Proteins outer can render a wide range activities NPs, including prolonged blood circulation, remarkable competency recognizing antigens enhanced better cellular interactions, gradual drug release, reduced toxicity vivo. In this review, nano‐based systems cells‐derived membranous layers, detailed production process, applicability treatment discussed. addition, future perspectives challenges translation also presented.

Язык: Английский

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Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

Advanced Science, Год журнала: 2019, Номер 6(12)

Опубликована: Апрель 24, 2019

Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one most common forms disease, characterized by a gradual formation atherosclerotic plaque, hardening, and narrowing arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy substantially limited in vivo due to nonspecific clearance mononuclear phagocytic system. In order address this limitation, rapamycin (RAP)-loaded poly(lactic-

Язык: Английский

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Tumor-Targeted Cascade Nanoreactor Based on Metal–Organic Frameworks for Synergistic Ferroptosis–Starvation Anticancer Therapy

ACS Nano, Год журнала: 2020, Номер 14(9), С. 11017 - 11028

Опубликована: Авг. 13, 2020

Although ferroptosis therapy has been proven to be a promising strategy for cancer treatment, its efficacy still might limited by insufficient H2O2 supply in tumor tissue. Herein, we designed cell membrane-cloaked cascade nanoreactor based on ferric metal–organic frameworks (MOF) and glucose oxidase (GOx) decoration synergistic ferroptosis–starvation anticancer therapy. The GOx can catalyze generate sufficient therapy, the consumption caused utilized as another attractive treatment called starvation When reached sites, high concentration of GSH reduced Fe3+ trigger structure collapse MOF release Fe2+ catalyzed oxidation H2O2. Then Fenton reaction happened between produce hydroxyl radicals (•OH) promoted With these reactions, was realized. Furthermore, membrane endows homologous targeting immune escaping ability, which facilitated accumulate into site with efficiency. exhibits efficiency suppression situ consumed produced compounds, promote development precise cooperative spatiotemporal controllability.

Язык: Английский

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Ice Inhibition for Cryopreservation: Materials, Strategies, and Challenges

Advanced Science, Год журнала: 2021, Номер 8(6)

Опубликована: Фев. 1, 2021

Abstract Cryopreservation technology has developed into a fundamental and important supporting method for biomedical applications such as cell‐based therapeutics, tissue engineering, assisted reproduction, vaccine storage. The formation, growth, recrystallization of ice crystals are the major limitations in cell/tissue/organ cryopreservation, cause fatal cryoinjury to cryopreserved biological samples. Flourishing anti‐icing materials strategies can effectively regulate suppress crystals, thus reducing damage promoting cryopreservation efficiency. This review first describes basic cryodamage mechanisms process. recent development chemical ice‐inhibition molecules, including cryoprotectant, antifreeze protein, synthetic polymer, nanomaterial, hydrogel, their summarized. advanced engineering strategies, trehalose delivery, cell encapsulation, bioinspired structure design inhibition, further discussed. Furthermore, external physical field technologies used inhibiting both cooling thawing processes systematically reviewed. Finally, current challenges future perspectives inhibition high‐efficiency proposed.

Язык: Английский

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Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Сен. 30, 2021

Cell membrane coated nanoparticles (NPs) have recently been recognized as attractive nanomedical tools because of their unique properties such immune escape, long blood circulation time, specific molecular recognition and cell targeting. However, the integrity coating on NPs, a key metrics related to quality these biomimetic-systems resulting biomedical function, has remained largely unexplored. Here, we report fluorescence quenching assay probe coating. In contradiction common assumption perfect coating, uncover that up 90% biomimetic NPs are only partially coated. Using in vitro homologous targeting studies, demonstrate could still be internalized by target cells. By combining simulations with experimental analysis, further identify an endocytic entry mechanism for NPs. We unravel high degree (≥50%) enter cells individually, whereas low (<50%) need aggregate together before internalization. This quantitative method fundamental understanding how will enhance rational designing nanosystems pave way more effective cancer nanomedicine.

Язык: Английский

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