An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing DOI Creative Commons
Ziyi Zhou, Dengjun Zhang, Xuchao Ning

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. In vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role in vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine.

Язык: Английский

Luteolin‐Loaded Hyaluronidase Nanoparticles with Deep Tissue Penetration Capability for Idiopathic Pulmonary Fibrosis Treatment DOI Open Access
Bo Pan,

Fangping Wu,

Shanming Lu

и другие.

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by sustained fibrotic lesions. Orally administered drugs usually fail to efficiently penetrate the tissue and reach lesions, resulting in low treatment efficiency. Luteolin (Lut) natural flavonoid, active metabolites of which possess antioxidant, anti‐inflammatory, anti‐fibrotic, anti‐apoptotic properties. In this study, nano‐formulation developed loading Lut into hyaluronidase nanoparticles (Lut@HAase). These Lut@HAase (NPs) exhibit small size good stability, suitable for noninvasive inhalation accumulation lungs, at site lesions can degrade hyaluronic acid tissue, enabling efficient penetration Lut. Lut's therapeutic effect, when via NPs, studied both vitro (using MRC5 cells) vivo IPF mice models), its anti‐fibrotic properties are found inhibit inflammation eliminate reactive oxygen species. Conclusively, study demonstrates that improve function enhance survival rates while reducing damage with few abnormalities during treatment.

Язык: Английский

Процитировано

3
Nanoparticles, a promising treatment for gastric cancer DOI Creative Commons
Hua Dong, Xiexing Wu,

Zebin Wu

и другие.

Smart Materials in Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
MicroRNAs in transplant rejection: Emerging roles in immune regulation and applications DOI
Shaochen Yu, Jian Lu

Transplant Immunology, Год журнала: 2025, Номер unknown, С. 102222 - 102222

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Engineered Macrophage Membrane-Coated Nanoparticles For Hepatic Ischemia–Reperfusion Injury Therapeutics DOI Creative Commons
Long Yang, Weiwei Li,

Zhen Huang

и другие.

Biomaterials Research, Год журнала: 2025, Номер 29

Опубликована: Янв. 1, 2025

Hepatic ischemia–reperfusion injury (HIRI) is a common perioperative complication occurring after liver transplantation and can lead to further problems such as early allograft dysfunction (EAD). Currently, the treatment options for HIRI are extremely limited. In this study, we used bioinformatics analysis elucidate critical role of neutrophil chemokines (CXC chemokines) in HIRI. By analyzing sequencing data from hepatic tissue posttransplant patients with EAD reperfused animal model, discovered that hepatocytes macrophages primary cells secreting CXC chemokines, activation nuclear factor kappa B (NF-κB) signaling pathway main driver their secretion. Melatonin (MT) protect oxidative harm while also inhibiting NF-κB signaling, suggesting its potential ameliorate Accordingly, designed nanoparticle platform coated genetically engineered macrophage membranes—called CXCR2-MM@PLGA/MT—to target chemokines. CXCR2 overexpression on membranes not only enhanced targeting capacity nanoparticles but prevented infiltration via scavenging Meanwhile, MT delivered site successfully attenuated chemokine release polarization hepatocyte necrosis by phosphorylation inducing antioxidant effects. Through synergistic effects CXCL/CXCR axis-blocking function nanoparticles, CXCR2-MM@PLGA/MT aggregation neutrophils at injury, markedly reducing local inflammation cellular damage following This nanoparticle-based therapy could thus serve safe, effective, cost-efficient strategy treating

Язык: Английский

Процитировано

0
Macrophage membrane-encapsulated miRNA nanodelivery system for the treatment of hemophilic arthritis DOI

Yufan Qian,

Yan Ma, Atanas Banchev

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 632 - 647

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

2
Mapping evolution and trends of cell membrane-coated nanoparticles: A bibliometric analysis and scoping review DOI Creative Commons
Chong Li, Jing Hu,

Jing He

и другие.

Nanotechnology Reviews, Год журнала: 2024, Номер 13(1)

Опубликована: Янв. 1, 2024

Abstract The limitations of traditional drug therapy have driven the creation and development novel cell membrane-coated nanoparticle (CMNP) platforms. Since introduction CMNP concept method in 2011, an increasing number studies focusing on this field been widely conducted. Despite growing body literature, comprehensive bibliometric analysis is still lacking. This study conducted a CMNP-related publications sourced from Web Science Core Collection database, covering period January 1, to December 31, 2023. included co-authorships, co-citations, co-occurrences countries, institutions, authors, references, keywords. Visualized tools such as Citespace, VOSviewer, R Package Bibliometrix were employed present data. A total 780 included, with China contributing highest (75.64%, n = 590). annual increased consistently 2011 2023, indicating global interest field. Prof. Liangfang Zhang United States recognized founder leading figure area. top three academic journals field, based publication volume, are ACS Nano (32 publications, IF 2022 17.1), Applied Materials Interfaces 9.5), Advanced Functional (31 19) among 185 scholarly journals. Reference keyword revealed that erythrocytes macrophage membranes significant research hotspots. primary diseases targeted by cancer pulmonary inflammation. In addition, CMNPs frequently studied conjunction photothermal photodynamic therapy. Furthermore, also summarized timelines for various membrane coating methods three-step preparation process CMNP. provides valuable insights guide future highlighting importance clinical application. Research nanomaterials, particularly those related inflammation, expected remain focal point. there need further other potential nanomaterials. serves resource researchers quickly comprehensively understand current hotspots emerging frontiers

Язык: Английский

Процитировано

0
An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing DOI Creative Commons
Ziyi Zhou, Dengjun Zhang, Xuchao Ning

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. In vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role in vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine.

Язык: Английский

Процитировано

0