Chemical Communications, Год журнала: 2024, Номер 60(50), С. 6427 - 6430
Опубликована: Янв. 1, 2024
We developed prodrug nanoparticles that release drugs through intracellular dissolution and a cancer-specific hydrogen peroxide response. To reveal the unclear mechanism regarding drug from by reacting with in cancer cells, this study demonstrates
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1582 - 1582
Опубликована: Дек. 11, 2024
Background: Achieving a balance between stable drug loading/delivery and on-demand activation/release at the target sites remains significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on design of molecules, offer promising strategy to optimize both delivery efficiency controlled release profiles. Methods: A library doxorubicin (DOX) prodrugs was created by linking DOX fatty alcohols varying chain lengths via tumor-responsive disulfide bond. In vitro studies assessed stability kinetics nanoassemblies. vivo evaluated their efficiency, tumor accumulation, antitumor activity in mouse models. Results: results demonstrated that longer alcohol chains improved nanoassemblies but slowed down disassembly process. DSSC16 NAs (hexadecanol-modified prodrug) significantly prolonged blood circulation time enhanced with AUC values 14.2-fold higher than DiR Sol. 4T1 tumor-bearing models, exhibited notably stronger activity, resulting final mean volume 144.39 ± 36.77 mm3, smaller all other groups (p < 0.05 ANOVA 95% confidence interval). Conclusions: These findings underscore critical role molecule development effective The is pivotal optimizing maximizing therapeutic efficacy.
Язык: Английский
Процитировано
14
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Nanomedicines capable of delivering multiple drugs have become essential in combination therapy. However, the challenges low drug loading capacity (DLC) and difficulties administering dosages between different significantly limit antitumor efficacy. In this study, a nanomedicine constructed through rational prodrug nanocarrier design was reported for cancer Initially, phenylborate ester (PBE) group-modified paclitaxel (PTX) (PTX-PBE) synthesized could self-assemble water. Subsequently, combretastatin A4 (CA4) polymer conjugates, mPEG-PCA4 (PCA4), were as nanocarriers to facilitate exceptionally high PTX-PBE precisely controlled manner. Both vitro vivo experiments demonstrated that PCA4 nanoparticles (PCA4/PTX-PBE NPs) exhibited potent efficacy favorable biocompatibility. Our approach provides straightforward, efficient, controllable strategy co-delivery pharmaceuticals clinical
Язык: Английский
Процитировано
2
Small, Год журнала: 2024, Номер 20(30)
Опубликована: Март 3, 2024
Abstract Doxorubicin (DOX) is widely used as a chemotherapeutic agent for both hematologic and solid tumors reasonable candidate glioma treatment. However, its effectiveness hindered by significant toxicity drug resistance. Moreover, the presence of blood–brain barrier (BBB) brings crucial challenge to therapy. In response, GSH‐responsive actively targeted nanoprodrug delivery system (cRGD/PSDOX‐Cur@NPs) are developed. this system, disulfide bond‐bridged DOX prodrug (PEG‐SS‐DOX) designed release specifically in high glutathione (GSH) tumor environment, markedly reducing cardiotoxicity associated with DOX. To further address resistance, curcumin, serving P‐glycoprotein (P‐gp) inhibitor, effectively increased cellular concentration. Consequently, cRGD/PSDOX‐Cur@NPs exhibited synergistic anti‐tumor effects vitro. Furthermore, vivo experiments validated superior BBB penetration brain‐targeting abilities cRGD/PSDOX‐Cur@NPs, showcasing remarkable potential treating subcutaneous orthotopic gliomas. This research underscores that presents novel approach inhibiting while addressing resistance systemic toxicity.
Язык: Английский
Процитировано
9
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 20, 2025
Abstract Despite the great potential of photodynamic therapy (PDT), its success remains compromised by abnormal redox homeostasis tumor cells, which supports survival, growth, and resistance to oxidative therapeutic interventions neutralizing reactive oxygen species (ROS). To overcome this barrier, a multifunctional prodrug nanomodulator (Pro@FLNC) is designed induce disulfidptosis immunogenic pyroptosis trigger an antitumor immune response. Pro@FLNC features core–shell structure where ursolic acid (UA) Chlorin e6 (Ce6) are conjugated via GSH‐responsive linker encapsulated in DSPE‐PEG‐FA lipid shell for enhanced stability, biocompatibility, tumor‐specific targeting. Within microenvironment (TME), depletes intracellular GSH, disrupts homeostasis, releases Ce6 UA, triggering stress mitochondrial dysfunction. These mechanisms amplify ROS production, promote peroxidation, initiate disulfidptosis, evidenced increased SLC7A11 expression F‐actin collapse. Elevated levels metabolic imbalance‐triggered further activate pyroptosis, releasing damage‐associated molecular patterns (DAMPs) that stimulate dendritic cell maturation cytotoxic T‐cell activation. Together, reshapes TME, reduces immunosuppressive promotes CD8 + infiltration, effectively suppressing primary tumors metastases. This programmed offers promising strategy enhance PDT immunotherapy advanced breast cancer.
Язык: Английский
Процитировано
1
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Апрель 17, 2025
Abstract Although cancer chemopreventive agents have been confirmed to effectively protect high-risk populations from invasion or recurrence, only over ten drugs approved by the U.S. Food and Drug Administration. Therefore, screening potent is crucial reduce constantly increasing incidence mortality rate of cancer. Considering lengthy prevention process, an ideal agent should be nontoxic, inexpensive, oral. Natural compounds become a natural treasure reservoir for chemoprevention because their superior ease availability, cost-effectiveness, safety. The benefits as in various studies. In light this, present review intended fully delineate entire scope chemoprevention, primarily focuses on aspects based compounds, specifically focusing mechanism action prevention, discussing detail how they exert effects affecting classical signaling pathways, immune checkpoints, gut microbiome. We also introduce novel strategies summarize role improving chemotherapy regimens. Furthermore, we describe discovering anticancer with low abundance high activity, revealing broad prospects drug discovery chemoprevention. Moreover, associate precision medicine, discuss challenges encountered Finally, emphasize transformative potential advancing field ability more effective less toxic preventive options oncology.
Язык: Английский
Процитировано
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
1
Biomacromolecules, Год журнала: 2024, Номер 25(3), С. 1838 - 1849
Опубликована: Фев. 20, 2024
Considering the complexity of physiological microenvironments and risks surgical infection, there still remains critical demand to develop a hydrogel as drug release platform with multifunctional properties, including good neutral stability sensitive multiple stimuli-responsive behaviors, well injectable self-healing properties. Herein, we present facile preparation injectable, hydrogels acid glutathione (GSH) dual-responsiveness for controlled delivery. Initially, anticancer camptothecin (CPT) was premodified disulfide bonds attached poly(ethylenimine) (PEI) via Schiff base reaction, resulting in PEI-CPT. Subsequently, OSA-IR780 synthesized through reaction involving IR780 amine groups (IR780-NH
Язык: Английский
Процитировано
6
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 670, С. 279 - 287
Опубликована: Май 15, 2024
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 133901 - 133901
Опубликована: Июль 20, 2024
Язык: Английский
Процитировано
4
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Сен. 25, 2024
Notable progress has been made in "ferroptosis-based nano drug delivery systems (NDDSs)" over the past 11 years. Despite ongoing absence of a comprehensive scientometric overview and up-to-date scientific mapping research, especially regarding evolution, critical research pathways, current landscape, central investigative themes, future directions.
Язык: Английский
Процитировано
4