Carbohydrate Polymers, Год журнала: 2024, Номер 351, С. 122967 - 122967
Опубликована: Ноя. 13, 2024
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 849 - 849
Опубликована: Июнь 22, 2024
The state of well-being and health our body is regulated by the fine osmotic biochemical balance established between cells different tissues, organs, systems. Specific districts human are defined, kept in correct functioning, and, therefore, protected from exogenous or endogenous insults both mechanical, physical, biological nature presence barrier In addition to placental barrier, which even acts as a linker two organisms, mother fetus, all barriers, including blood-brain (BBB), blood-retinal blood-nerve blood-lymph blood-cerebrospinal fluid operate maintain physiological homeostasis within tissues organs. From pharmaceutical point view, most challenging undoubtedly BBB, since its notably complicates treatment brain disorders. BBB action can impair delivery chemical drugs biopharmaceuticals into brain, reducing their therapeutic efficacy and/or increasing unwanted bioaccumulation surrounding healthy tissues. Recent nanotechnological innovation provides advanced biomaterials ad hoc customized engineering functionalization methods able assist brain-targeted drug delivery. this context, lipid nanocarriers, synthetic (liposomes, solid nanoparticles, nanoemulsions, nanostructured carriers, niosomes, proniosomes, cubosomes) cell-derived ones (extracellular vesicles cell membrane-derived nanocarriers), considered one successful systems due reasonable biocompatibility ability cross BBB. This review aims provide complete up-to-date view on varied whether FDA-approved, involved clinical trials, used vitro vivo studies, for inflammatory, cancerous, infectious diseases.
Язык: Английский
Процитировано
7
Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1120 - 1120
Опубликована: Авг. 24, 2024
Natural photosensitizers (PS) are compounds derived from nature, with photodynamic properties. PSs have a similar action to that of commercial PSs, where cancer cell death occurs by necrosis, apoptosis, and autophagy through ROS generation. garnered great interest over the last few decades because their high biocompatibility good photoactivity. Specific wavelengths could cause phytochemicals produce harmful for therapy (PDT). However, natural some shortcomings, such as reduced solubility lower uptake, making them less appropriate PDT. Nanotechnology offers an opportunity develop suitable carriers various PDT applications. Various nanoparticles been developed improve outcome enhanced solubility, optical adsorption, tumor targeting. Multidrug resistance (MDR) is phenomenon in which cells wide range structurally functionally unrelated drugs. Over decade, several researchers extensively studied effect PS-based treatment (PDT) on MDR cells. Though outcomes clinical trials were inconclusive, significant advancement still required before can be used agent treating tumors. This review addresses increasing literature progression efficacy PDT, emphasizing importance developing new nano-based fight against features photosensitizing regimen.
Язык: Английский
Процитировано
7
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105980 - 105980
Опубликована: Июль 16, 2024
The current standard therapy for GBM includes maximal surgical resection, followed by concurrent radiotherapy and oral chemotherapy; however, the median post-diagnosis survival period is only 15–18 months. Nanoparticles (NPs) their composite drug delivery systems (DDSs)—particularly those with liposomes polymeric nanoparticles (PNPs)—have become an increasingly popular route therapeutic in glioblastoma multiforme (GBM). These also have added benefit of enabling combinational therapies, which particularly necessary more resilient cancers like GBM. To ensure most effective means targeting tumor microenvironment (TME), stem cells (GSCs) can be used, both as targets vectors—both avenues showing promising results. However, DDSs directed towards brain must overcome many barriers associated cranial administration—including blood-brain-barrier (BBB) its derivatives, intracranial fluid pressure, induced regression from NP activating protocols involving heat or electromagnetic radiation, extended retention synthetic within tissue—before they finally circulate clinical domain. In this article, we review progress made incorporating GSCs design, well challenges that need to addressed facilitate a widespread regimen successfully treating
Язык: Английский
Процитировано
5
Regenerative Biomaterials, Год журнала: 2024, Номер 12
Опубликована: Ноя. 20, 2024
Abstract Low tumor enrichment remains a serious and urgent problem for drug delivery in cancer therapy. Accurate targeting of sites is still critical aim Though there have been variety strategies to improve the enrichment, biological barriers cause most delivered guests fail or be excreted before they work. Recently, cell membrane-based systems attracted huge amount attention due their advantages such as easy access, good biocompatibility immune escape, which contribute biomimetic structures specific surface proteins. Furthermore, are referred homologous-targeting function exhibit significantly high adhesion internalization homologous-type cells even though exact mechanism not entirely revealed. Here, we summarize sources characterizations membrane systems, including reconstructed single hybrid nano-/microcarriers, well engineered cells. Additionally, advanced applications these therapy categorized summarized according components membranes. The potential factors related homologous also discussed. By discussing applications, challenges opportunities, expect far-reaching development preclinic clinics.
Язык: Английский
Процитировано
4
Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1742 - 1742
Опубликована: Дек. 23, 2024
Designing and standardizing drug formulations are crucial for ensuring the safety efficacy of medications. Nanomedicine utilizes nano delivery systems advanced nanodevices to address numerous critical medical challenges. Currently, oral intranasal aerosol (OIADD) is primary method treating respiratory diseases worldwide. With advancements in disease understanding development aerosolized systems, application OIADD has exceeded its traditional boundaries, demonstrating significant potential treatment non-respiratory conditions as well. This study provides a comprehensive overview applications treatment. It examines key challenges limiting nanomedicines formulation processes, devices explores latest these areas. review aims offer valuable insights researchers involved platforms.
Язык: Английский
Процитировано
3
Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101021 - 101021
Опубликована: Янв. 1, 2025
Although with aggressive standards of care like surgical resection, chemotherapy, and radiation, high-grade gliomas (HGGs) brain metastases (BM) treatment has remained challenging for more than two decades. However, technological advances in this field immunotherapeutic strategies have revolutionized the HGGs BM. Immunotherapies immune checkpoint inhibitors, CAR-T targeting, oncolytic virus-based therapy, bispecific antibody treatment, vaccination approaches, etc., are emerging as promising avenues offering new hope refining patient's survival benefits. selective trafficking across blood-brain barrier (BBB), immunosuppressive tumor microenvironment (TME), metabolic alteration, heterogeneity limit therapeutic efficacy immunotherapy Furthermore, to address concern, NanoBioTechnology-based bioinspired delivery system been gaining tremendous attention recent years. With such Trojan horse targeting infusing/camouflaging nanoparticles surface biological molecules/cells immunocytes, erythrocytes, platelets, glioma cell lysate and/or integrating these get hybrid membrane homotypic recognition. These biomimetic nanotherapy offers advantages over conventional nanoparticles, focusing on greater target specificity, increased circulation stability, higher active loading capacity, BBB permeability (inherent inflammatory chemotaxis neutrophils), decreased immunogenicity, efficient metabolism-based combinatorial effects, prevention recurrence by induction immunological memory, etc. provide age improved immunotherapies outcomes against In review, we emphasize neuro-immunotherapy versatility nano-delivery precise hard-to-treat most lethal Moreover, challenges impeding clinical translatability approaches were addressed unmet medical needs cancers.
Язык: Английский
Процитировано
0
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Май 5, 2025
ABSTRACT Cell membrane coating (CMC) of nanoparticles (NPs) has emerged as a prominent strategy that gained significant attention and achieved notable progress across various therapeutic sectors. Coating NPs with natural cell membranes endows them functions addresses challenges in drug delivery, such prolonging circulation time, reducing immunogenicity, improving targeting efficiency cellular communication. Among the different NPs, lipid (LNPs) have revolutionized field nanomedicine by providing advantageous features for delivery. The versatile characteristics LNPs synergize well membranes’ biomimetic properties, creating hybrid structures enhanced functionalities diverse biomedical applications. A more advanced form significantly capabilities can be through CMC. However, opportunities remain further advancements, ongoing efforts focused on discovering innovative applications fully harnessing potential this promising combination. This article provides critical review recent coated‐LNPs (CMC‐LNPs). First, LNP types, their preparation methods, strategies are summarized. development, functions, CMC‐LNPs then discussed. Last, advantages, limitations, challenges, future perspectives presented.
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2024, Номер 351, С. 122967 - 122967
Опубликована: Ноя. 13, 2024
Язык: Английский
Процитировано
2