Abstract
In
pharmaceuticals,
the
structural
and
functional
alterations
induced
by
biotransformation
are
well‐documented.
Many
pharmaceuticals
exist
in
various
crystal
forms,
which
govern
their
transformation
significantly
impact
activity.
However,
field
of
inorganic
nanomedicine,
there
is
a
paucity
research
focusing
on
influence
form‐dependent
“metabolism”
(transformation)
activity
biomechanism.
This
study
delves
into
distinct
performances
two
forms
manganese
sulfide
(MnS),
namely
α‐MnS
γ‐MnS,
bacteria‐infected
diabetic
wound
healing.
initial
stage
wound,
where
environment
neutral
to
slightly
alkaline,
MnS
partially
converts
Mn
x
O
y
(comprising
2
3
4
)
concurrently
produces
hydrogen
(H
S);
conversion
efficiency
γ‐MnS
surpasses
that
α‐MnS.
Additionally,
more
soluble
than
α‐MnS,
allows
it
generate
2+
.
These
components
collectively
contribute
superior
bacteriostatic
properties
MnS.
related
cells,
stimulates
production
collagen
I
vascular
endothelial
growth
factor
(VEGF),
promote
M1
macrophages
polarizing
M2
phenotype,
for
extracellular
matrix
(ECM)
remodeling.
Notably,
different
products
have
functions.
Consequently,
dependent
its
original
form
solubility
efficiency.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(31)
Опубликована: Авг. 22, 2024
The
prevalence
of
drug-resistant
bacterial
infections
has
emerged
as
a
grave
threat
to
clinical
treatment
and
global
human
health,
presenting
one
the
foremost
challenges
in
medical
care.
Thus,
there
is
an
urgent
imperative
develop
safe
efficacious
novel
antimicrobial
strategies.
Nitric
oxide
(NO)
recognized
endogenous
signaling
molecule,
which
plays
pivotal
role
numerous
pathological
processes.
Currently,
NO
garnered
significant
interest
antibacterial
agent
due
its
capability
eradicate
bacteria,
disrupt
biofilms,
facilitate
wound
healing,
all
while
circumventing
emergence
drug
resistance.
However,
inherently
unstable
characteristic
therapeutic
gas
renders
controlled
administration
gases
exceedingly
challenging.
Hence,
this
review,
current
challenge
infection
discussed;
then
it
briefly
elucidated
mechanism
comprehensively
delineate
recent
advancements
stimulus-responsive
delivery
platforms,
along
with
their
merits,
obstacles,
prospective
avenues
for
application.
This
review
offers
guidance
future
NO-medicated
anti-infection
therapy
hoped.
ACS Nano,
Год журнала:
2024,
Номер
18(24), С. 15681 - 15694
Опубликована: Июнь 7, 2024
The
prolonged
wound-healing
process
caused
by
pathogen
infection
remains
a
major
public
health
challenge.
developed
electrical
antibiotic
administration
typically
requires
metal
electrodes
wired
to
continuous
power
supply,
restricting
their
use
beyond
clinical
environments.
To
obviate
the
necessity
for
antibiotics
and
an
external
source,
we
have
wearable
synergistic
electroceutical
device
composed
of
air
self-charging
Zn
battery.
This
battery
integrates
sustained
tissue
regeneration
antibacterial
modalities
while
maintaining
more
than
half
initial
capacity
after
ten
cycles
chemical
charging.
In
vitro
bacterial/cell
coculture
with
demonstrates
inhibited
bacterial
activity
enhanced
cell
function
simulating
endogenous
electric
field
dynamically
engineering
microenvironment
released
chemicals.
provides
accelerated
healing
bacteria-infected
wound
stimulating
angiogenesis
modulating
inflammation,
effectively
inhibiting
growth
at
site.
Considering
simple
structure
easy
operation
long-term
treatment,
this
offers
great
potential
personalized
care.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 26, 2024
Abstract
Diabetic
foot
ulcer
typically
undergoes
a
delayed
wound‐healing
process
owing
to
the
disordered
microenvironment,
including
persistent
inflammation,
long‐term
hypoxia,
and
excessive
fibrosis,
eventually
leading
severe
disabilities
other
poor
outcomes.
However,
current
strategies
cannot
meet
dynamic
demands
during
process.
Herein,
reactive
oxygen
species
(ROS)–responsive
oxygen‐generating
microneedle
platform,
consisting
of
sericin‐based
glucose‐responsive
hydrogel
loaded
with
verteporfin,
for
effective
diabetic
wound
healing
is
proposed.
Under
highly
oxidative
functionalized
sericin
protein
depletes
overproduced
ROS
generate
oxygen,
which
can
not
only
alleviate
hypoxic
microenvironment
promote
angiogenesis
by
activating
extracellular
signal‐regulated
kinase
Heme
Oxygenase‐1
pathways
but
also
decrease
expression
proinflammatory
cytokines.
Moreover,
hyperglycaemic
condition
triggers
gradual
dissociation
this
platform
promotes
release
verteporfin
enhance
scarless
re‐epithelization
via
inhibiting
yes‐associated
signal.
This
versatile
system
integrates
advantageous
features
inflammation
alleviation,
promotion,
scar
inhibition
capabilities,
accelerates
repair
in
vivo,
offers
novel
approach
self‐supply
remodeling.
Biomacromolecules,
Год журнала:
2025,
Номер
26(1), С. 201 - 208
Опубликована: Янв. 2, 2025
Tissue
repair
is
often
impaired
in
pathological
states,
highlighting
the
need
for
innovative
wound-healing
technologies.
This
study
introduces
composite
hyaluronic
acid
gas-entrapping
materials
(GEMs)
delivering
carbon
monoxide
(CO)
to
promote
wound
healing
pigs.
These
facilitate
burst
release
followed
by
sustained
of
CO
over
48
h.
In
a
porcine
full-thickness
model,
CO-GEMs
significantly
accelerated
closure
compared
standard-of-care
dressing
(Tegaderm).
Wound
area
with
was
68.6%
vs
56.8%
on
day
14,
41.0%
25.1%
28,
and
26.9%
11.8%
42,
effectively
reducing
time
14
days.
Histological
analysis
revealed
increased
epithelialization
neovascularization
reduced
inflammation.
findings
demonstrate
potential
as
topical
therapeutic
enhance
tissue
clinically
relevant
models,
supporting
further
testing
applications.
Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 228 - 228
Опубликована: Янв. 18, 2025
Promoting
rapid
healing
is
a
concern
in
skin
wound
treatment,
as
the
increased
pain
and
loss
of
functional
ability
when
wounds
become
chronic
create
complex
problem
to
manage.
This
scoping
review
aimed
explore
literature
synthesize
existing
knowledge
on
therapeutic
use
CO2
treating
cutaneous
wounds.
The
was
selected
using
previously
defined
inclusion
exclusion
criteria,
22
articles
were
for
data
extraction.
most
researched
type
injury
located
extremities
limbs.
Carboxytherapy
performed
five
different
ways:
subcutaneous,
intradermal,
or
intralesional
injections;
hot
water
baths
with
temperatures
ranging
from
30
42
°C;
transcutaneous
application;
intra-abdominal
insufflation;
paste
local
application.
main
effects
therapy
described
follows:
improved
blood
flow
oxygenation,
reduction
inflammatory
process,
collagen
production,
clinical
aspects
wounds,
faster
healing.
can
be
considered
good
alternative
although
further
studies
should
pursued
elucidate
its
molecular
mechanisms
enhance
efficacy.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Gas
therapy
using
gasotransmitters
is
of
exponential
interest
due
to
the
growing
recognition
gas
signaling
molecules
that
can
be
involved
in
multiple
therapeutic
actions.
Finding
suitable
methods
for
delivering
these
crucial,
and
porous
materials,
notably
metal-organic
frameworks
(MOFs),
have
shown
exceptional
potential
as
carriers,
enabling
safe
controlled
local
delivery.
The
challenges
translate
MOF
therapies
clinical
use
require
not
only
validate
mechanisms
action
pathways
released
but
also
get
a
deep
understanding
into
rational
design,
it
requires
combination
features
maximize
outcomes.
In
this
perspective,
we
outline
key
criteria
designing
MOFs
delivery
applications
highlight
expanding
range
opportunities
materials
may
offer.
Readers
insights
design
develop
gasotransmitter
with
realistic
clinic
interest.
