Gelatin methacryloyl-phenylboronic acid/Hydroxyadamantane self-healing microgels for the periodontitis treatment by promoting alveolar bone regeneration
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140434 - 140434
Опубликована: Янв. 1, 2025
Язык: Английский
Polysaccharides, proteins and DNA based stimulus responsive hydrogels promoting wound healing and repair: A review
Yanfen She,
Peng Wu,
Wenyu Wan
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
304, С. 140961 - 140961
Опубликована: Фев. 12, 2025
Язык: Английский
Effect of microbe‐derived antioxidants on intestinal oxidative stress, NLRP3 inflammasome, morphologic structure, and growth performance in weanling piglets
Journal of Food Science,
Год журнала:
2025,
Номер
90(3)
Опубликована: Март 1, 2025
Weaning
stress
induces
pigs
oxidative
stress,
which
decreases
growth
performance,
causes
intestinal
damage,
and
increases
diarrhea
death
in
piglets.
Microbe-derived
antioxidants
(MA)
have
an
antioxidant
immune-modulatory
role,
but
the
impacts
of
MA
on
structure
function,
inflammatory
response
weaned
piglets
are
unclear.
To
elucidate
whether
can
modulate
response,
barrier
function
impairment
possible
mechanisms
its
modulation,
a
total
60
DLY
(a
crossbreed
Duroc,
Landrance,
Yorkshire)
were
randomly
selected
from
6
litters,
with
10
each
litter.
Piglets
same
litter
similar
body
weight
(6.44
±
0.08
kg)
assigned
to
two
groups:
group
control
(Con).
Results
indicated
that
treatment
markedly
increased
(p
<
0.01)
average
daily
gain
feed
intake
while
decreasing
F/G
(feed
conversion
ratio)
at
days
21-41.
The
addition
noticeably
inhibited
ROS-NLRP3-IL-1β
pathway
0.05)
decreased
factors
such
as
IL-1β
IL-18
intestine
0.01).
Moreover,
supplementation
significantly
reduced
jejunal
myosin
light-chain
kinase
content
increasing
ZO-1
Occludin
0.05).
resulted
noticeable
rise
colonic
CD206+
positive
cells
mRNA
expression
iNOS
0.01),
COX2
0.05),
TLR4
MyD88
NF-κB
also
activated
Nrf2-HO-1
These
discoveries
imply
improve
capacity
by
activating
Nrf2
pathway,
alleviate
inflammation
inhibiting
activation
regulating
polarization
macrophages,
ultimately
performance
Язык: Английский
Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 12, 2025
Periodontitis,
a
chronic
inflammatory
disease
caused
by
bacteria,
is
characterized
localized
reactive
oxygen
species
(ROS)
accumulation,
leading
to
an
response,
which
in
turn
leads
the
destruction
of
periodontal
supporting
tissues.
Therefore,
antibacterial,
scavenging
ROS,
reducing
regulating
microenvironment,
and
alleviating
alveolar
bone
resorption
are
effective
methods
treat
periodontitis.
In
this
study,
we
developed
ROS-responsive
injectable
hydrogel
modifying
hyaluronic
acid
with
3-amino
phenylboronic
(PBA)
reacting
it
poly(vinyl
alcohol)
(PVA)
form
borate
bond.
addition,
encapsulated
antibacterial
agent
minocycline
hydrochloride
(MH)
Fe-Quercetin
anti-inflammatory
nanoparticles
(Fe-Que
NPs)
for
on-demand
drug
release
response
periodontitis
microenvironment.
This
(HP-PVA@MH/Fe-Que)
exhibited
highly
properties.
Moreover,
modulating
Nrf2/NF-κB
pathway,
effectively
eliminated
ROS
promoted
macrophage
polarization
M2
phenotype,
inflammation
enhancing
osteogenic
differentiation
potential
human
ligament
stem
cells
(hPDLSCs)
Animal
studies
showed
that
HP-PVA@MH/Fe-Que
significantly
reduced
loss
enhanced
factor
expression
killing
bacteria
inhibiting
inflammation.
Thus,
had
efficient
ROS-scavenging,
anti-inflammatory,
resorption-alleviation
abilities,
showing
excellent
application
healing.
Язык: Английский
Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Abstract
Advanced
periodontitis
initiates
with
Porphyromonas
gingivalis
(
P.
)
infection,
which
subsequently
triggers
chronic
inflammation,
immune
imbalance,
and
ultimately
causes
alveolar
bone
resorption.
Traditional
periodontal
treatment
focuses
on
the
elimination
of
triggering
factors,
but
tend
to
ignore
improvement
inflammatory
microenvironment
remodeling
osteogenic
mineralization
space.
Herein,
zinc‐aluminum
layered
double
hydroxide
nanosheets
(LDHs)
loaded
icariin
(ICA)
are
encapsulated
into
a
gallic
acid
(GA)‐modified
hydroxybutyl
chitosan
hydrogel
(GA‐HBC),
giving
rise
customized
system
named
GA‐HBC‐LIC,
can
sequentially
actualize
antibacterial,
anti‐inflammatory,
remineralization
functions.
A
neutral
chemical‐humoral
space
is
created
for
osteogenesis
via
means
sequential
regulation
by
smart
hydrogel.
Concomitantly,
appropriate
mechanical
properties
degradation
performance
provide
desirable
physical
remineralization.
In
spatiotemporal
modulation
hydrogel,
zinc
finger
E‐box‐binding
homeobox
1
(ZEB1)
target
released
ions
(Zn
2+
action
promotes
macrophage
polarization
from
M1
M2
phenotype,
thereby
releasing
cytokines
conducive
tissue
regeneration.
sum,
this
study
highlights
critical
role
inflammation
maintenance
in
regeneration
tissues,
offering
new
insights
clinical
management
periodontitis.
Язык: Английский
Hydrogel design and applications for periodontitis therapy: A review
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 137893 - 137893
Опубликована: Ноя. 1, 2024
Язык: Английский
Bioactive Hydrogel Formulation Based on Ferulic Acid-Grafted Nano-Chitosan and Bacterial Nanocellulose Enriched with Selenium Nanoparticles from Kombucha Fermentation
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(7), С. 202 - 202
Опубликована: Июль 22, 2024
Selenium
nanoparticles
(SeNPs)
have
specific
properties
that
result
from
their
biosynthesis
particularities.
Chitosan
can
prevent
pathogenic
biofilm
development.
A
wide
palette
of
bacterial
nanocellulose
(BNC)
biological
and
physical-chemical
are
known.
The
aim
this
study
was
to
develop
a
hydrogel
formulation
(SeBNCSFa)
based
on
ferulic
acid-grafted
chitosan
enriched
with
SeNPs
Kombucha
fermentation
(SeNPsK),
which
could
be
used
as
an
adjuvant
for
oral
implant
integration
other
applications.
grafted
SeBNCSFa
were
characterized
by
biochemical
methods.
cell
viability
proliferation
HGF-1
gingival
fibroblasts
investigated,
well
in
vitro
antioxidant
activity.
inflammatory
response
determined
enzyme-linked
immunosorbent
assay
(ELISA)
the
proinflammatory
mediators
(IL-6,
TNF-α,
IL-1β)
culture
medium.
Likewise,
amount
nitric
oxide
released
measured
Griess
reaction.
antimicrobial
activity
also
investigated.
grafting
degree
acid
approximately
1.780
±
0.07%
total
monomeric
units,
assuming
single-site
per
monomer.
Fourier-transform
infrared
spectroscopy
evidenced
convolution
BNC
spectra,
X-ray
diffraction
analysis
highlighted
amorphous
rearrangement
patterns,
suggesting
multiple
interactions.
showed
high
cytocompatibility,
enhanced
antioxidant,
anti-inflammatory,
potentials.
Язык: Английский
Two birds with one stone: Natural polyphenols boosted periodontitis treatment of chlorhexidine via reducing toxicity and regulating microenvironments
Zhiyuan Sun,
Tianyou Wang,
Enni Chen
и другие.
Materials Horizons,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Chlorhexidine
(CHX)
is
considered
the
gold
standard
for
controlling
periodontal
plaque
and
has
been
extensively
used
as
a
topical
agent
in
treating
periodontitis.
Nevertheless,
practical
clinical
application
of
CHX
still
constrained
by
inherent
limitations
its
properties,
including
toxicity,
inadequate
biofilm
scavenging
capacity,
single
biological
effect.
In
this
study,
polyphenolic
epigallocatechin
gallate
(EGCG)
employed
to
integrate
with
form
an
EGCG-CHX
nanoplatform
Язык: Английский
A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment
Biomaterials,
Год журнала:
2024,
Номер
316, С. 123024 - 123024
Опубликована: Дек. 16, 2024
Язык: Английский
Toward Novel Porous Boronized Ti6Al4V/FHA Composite Implants by Combined Microwave Sintering and Temporary Space Alloying
Small Structures,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Titanium
alloys
are
unsuitable
implants
for
patients
with
low
bone
quality
due
to
their
high
moduli
and
bioinertness.
In
this
study,
porous
boronized
Ti6Al4V/fluorohydroxyapatite
(FHA)
composites
synthesized
via
microwave
sintering
of
mixed
Ti6Al4V,
FHA
TiB
2
powders
at
1050
°C
30
min,
0–10
wt%
urea
as
a
space
holder
material.
It
is
shown
that
increasing
addition
leads
higher
porosity,
promoting
penetration
“lens
effect”,
which
improves
boronization
restrains
degradation
mechanical
properties
the
caused
by
increased
porosity.
With
0–3
wt%,
compressive
strength
modulus
decrease
from
380.3
MPa
14.5
GPa
134.4
3.26
GPa,
respectively,
while
Vickers
microhardness
declines
360.3
300.0
HV.
The
exposure
chemical
biological
composite,
water
contact
angle
decreased
nearly
half
osteogenesis
sixfold.
By
adding
more
urea,
decreases
evidently,
poorer
wettability
biocompatibility
looser
structure
decomposition.
3
composite
achieves
an
optimal
balance
between
ultralow
enhanced
bioactivity,
making
it
ideal
rapid
osseointegration
in
poor
conditions.
Язык: Английский