Programmed Fabrication of Vesicle‐Based Prototissue Fibers with Modular Functionalities
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Abstract
Multicellular
organisms
have
hierarchical
structures
where
multiple
cells
collectively
form
tissues
with
complex
3D
architectures
and
exhibit
higher‐order
functions.
Inspired
by
this,
to
date,
protocell
models
been
assembled
tissue‐like
termed
prototissues.
Despite
recent
advances
in
this
research
area,
the
programmed
assembly
of
protocells
into
prototissue
fibers
emergent
functions
still
represents
a
significant
challenge.
The
possibility
assembling
will
open
up
way
novel
type
subunit
capable
unprecedented
soft
functional
materials
tunable
architectures,
modular
distributed
functionalities.
Herein,
first
method
fabricate
freestanding
vesicle‐based
controlled
lengths
diameters
is
devised.
Importantly,
it
also
shown
that
can
be
composed
different
specialized
modules
that,
for
example,
endow
fiber
magnetotaxis
capabilities,
or
work
synergistically
take
an
input
diffusible
chemical
signals
transduce
readable
fluorescent
output
through
hosted
enzyme
cascade
reaction.
Overall,
addresses
important
challenge
engineering
find
applications
bio‐printing,
tissue
engineering,
robotics
as
next‐generation
bioinspired
materials.
Язык: Английский
Engineering Protocell Networks for Prototissue Development
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
The
assembly
of
protocells
into
prototissues
represents
a
significant
step
forward
in
mimicking
the
hierarchical
structure
and
complex
functions
biological
tissues.
This
review
explores
construction
various
protocell
models,
including
lipid
vesicles,
polymer
proteinosomes,
membraneless
coacervates,
emulsion
droplets.
It
examines
range
chemical
physical
methods
employed
to
spatially
organize
these
structured,
functional
prototissues.
Furthermore,
highlights
distinctive
properties
prototissues,
such
as
their
ability
facilitate
intra-
inter-protocell
communication,
exhibit
collective
behaviors
like
oscillations
deformation,
promising
applications
biomedicine.
By
bridging
gap
between
synthetic
cells
tissue-like
systems,
this
provides
insights
design,
fabrication,
potential
biology
regenerative
medicine.
Язык: Английский
Matching Together Living Cells and Prototissues: Will There Be Chemistry?
ChemBioChem,
Год журнала:
2024,
Номер
25(18)
Опубликована: Июнь 21, 2024
Abstract
Scientific
advancements
in
bottom‐up
synthetic
biology
have
led
to
the
development
of
numerous
models
cells,
or
protocells.
To
date,
research
has
mainly
focused
on
increasing
(bio)chemical
complexity
these
bioinspired
micro‐compartmentalized
systems,
yet
successful
integration
protocells
with
living
cells
remains
one
major
challenges
biology.
In
this
review,
we
aim
summarize
current
state
art
hybrid
protocell/living
cell
and
prototissue/living
systems.
Inspired
by
recent
breakthroughs
tissue
engineering,
review
chemical,
bio‐chemical,
mechano‐chemical
aspects
that
hold
promise
for
achieving
an
effective
non‐living
matter.
The
future
production
fully
integrated
systems
increasingly
complex
not
only
potential
revolutionize
field
but
also
paves
way
new
technologies
(bio)sensing,
personalized
therapy,
drug
delivery.
Язык: Английский
Supramolecular Systems Chemistry Based on the Interplay between Peptides and Porphyrins
ChemSystemsChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
The
functions
of
living
organisms
are
emergent
from
networks
biomolecules.
In
this
review,
we
discuss
the
creation
synthetic
life‐like
systems
based
on
interplay
peptides
and
porphyrins
in
supramolecular
chemical
systems.
particular,
focus
spatiotemporal
control
self‐assembly
processes,
which
allows
for
development
hierarchical
structures
biomimetic
catalysis
adaptive
dynamics
stimulus‐responsive
structural
transformations.
Notably,
when
operating
a
nonequilibrium
regime–characterized
by
kinetic
traps,
feedback
loops,
dissipative
conditions–the
landscape
expands
system‐level
properties
emerge,
including
transient
catalysis,
metabolic
self‐replication,
Darwinian‐like
evolution.
Controlling
these
at
biointerface
would
facilitate
intelligent
therapeutic
interventions
anti‐tumor
phototherapy.
Supramolecular
chemistry
provides
valuable
framework
exploring
new
physicochemical
spaces
porphyrins,
may
offer
distinct
advantages
extensive
applications
across
diverse
fields.
Язык: Английский