Peptide nanozymes: An emerging direction for functional enzyme mimics

Bioactive Materials, Год журнала: 2024, Номер 42, С. 284 - 298

Опубликована: Сен. 4, 2024

Язык: Английский

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Coacervates Composed of Low‐Molecular‐Weight Compounds– Molecular Design, Stimuli Responsiveness, Confined Reaction

Advanced Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

The discovery of coacervation within living cells through liquid-liquid phase separation has inspired scientists to investigate its fundamental principles and significance. Indeed, coacervates composed low-molecular-weight compounds based on supramolecular strategy can offer valuable models for biomolecular condensates useful tools. This mini-review highlights recent findings advances in (artificial condensates), primarily compounds, with focuses their molecular design, stimuli responsiveness, controlled reactions or leading the coacervates.

Язык: Английский

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Supramolecular J‐ and H‐aggregation of Napthalimide‐conjugated Dipeptide in Mixed‐solvent Systems and Its Application in Cell Imaging

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(22)

Опубликована: Авг. 6, 2024

Abstract In this work, a core‐substituted NMI‐conjugated dipeptide (4MNLV) was extensively studied in mixed solvent systems to explore the polarity effect on self‐assembly pattern and their photophysical property. 4MNLV adopted J‐ or H ‐ type aggregation depending upon index of system chosen. The process achieved through anti‐solvent effect. UV‐vis study suggested that if stock solution diluted with relatively more polar (compared solvent), then acquired by showing red‐shift absorption maxima (λ max ). Conversely, when less solvent, H‐ observed, where blue shift λ noticed. emission spectra lifetime self‐assembled materials were also influenced chosen system. chirotopic behaviour these CD spectroscopy. Morphological indicated formation helical nanofibrillar structures. bright green fluorescence highly biocompatible naphthalimide‐peptide conjugate used for cell imaging application, indicating its futuristic scope.

Язык: Английский

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Supramolecular Gelation Based on Native Amino Acid Tyrosine and Its Charge-Transfer Complex Formation

Langmuir, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Self-assembly of amino acids and short-peptide derivatives attracted significant curiosity worldwide due to their unique self-assembly process wide variety applications. Amino acid is considered one the important synthons in supramolecular chemistry. processes applications unfunctionalized native have been less reported literature. In this article, we are first-time reporting tyrosine (Tyr), an aromatic acid, dimethyl sulfoxide (DMSO) solvent. Most studies related Tyr were different aqueous solutions. our work, studied several common organic solvents found that could self-assemble into a gel The was investigated by techniques, such as UV-vis, fluorescence, FTIR, NMR spectroscopy. Morphological features on nanoscale through scanning electron microscopy (SEM). SEM images indicated formation nanofibrils with high aspect ratios. property rheological experiments. Computational study DMSO medium suggested noncovalent interactions like hydrogen bonding π-π stacking among molecules played prominent role. Finally, charge-transfer complex ability electron-rich electron-deficient 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) studied. presence DDQ formation, converted reddish color solution, fibrillar morphologies collapsed.

Язык: Английский

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Fmoc-conjugated dipeptides-based hydrogels and their pH-tuneable behaviour

Soft Matter, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Fmoc-dipeptide-based thixotropic, injectable, and biocompatible hydrogels were developed. Hydrogel properties highly dependent on the pH of solution.

Язык: Английский

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