Environmental Toxicology,
Год журнала:
2023,
Номер
38(12), С. 2857 - 2866
Опубликована: Сен. 4, 2023
Drug
resistance
is
a
considerable
obstacle
to
gastric
cancer
(GC)
treatment.
The
current
work
aimed
elucidate
the
functional
mechanism
of
CD109
in
5-fluorouracil
(5-FU)
GC.
In
this
study,
we
demonstrated
that
was
extremely
heightened
5-FU-resistant
GC
cells.
deficiency
lessened
IC50
value,
impaired
cell
viability
and
metastatic
capability,
induced
apoptosis
after
5-FU
treatment
addition,
found
PAX5
bound
p300
increased
enrichment
H3K27ac
at
promoter
region
gene,
which
resulted
upregulation
Moreover,
also
revealed
triggered
via
activating
JNK/MAPK
signaling.
Blockage
signaling
using
JNK
inhibitor,
SP600125,
abolished
upregulation-induced
changes
values,
viability,
metastasis
NCI-N87/5-FU
SNU-1/5-FU
Importantly,
silencing
enhanced
therapeutic
efficacy
5-FU,
leading
reduced
tumor
growth
vivo.
conclusion,
our
results
unveiled
H3K27
acetylation
activated-CD109
cells
modulating
pathway,
might
provide
an
attractive
target
for
In Vivo,
Год журнала:
2024,
Номер
38(5), С. 2152 - 2164
Опубликована: Янв. 1, 2024
Oral
squamous
cell
carcinoma
(OSCC)
presents
a
significant
health
challenge,
requiring
effective
treatments.
Magnolol,
compound
with
potential
anticancer
properties,
warrants
investigation
in
OSCC
treatment.
Here,
we
aimed
to
assess
the
efficacy
of
magnolol
inhibiting
progression
and
explore
underlying
mechanisms
its
action.
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Окт. 18, 2024
Docetaxel
(DTX)
resistance
attenuates
anti-tumor
effects
of
DTX
on
prostate
cancer
(mCRPC)
and
drug
was
related
to
Treg
expansion
in
tumors.
ZNF667-AS1
played
a
suppressing
role
various
tumors
tumor-derived
exosomes
carry
lncRNAs
participate
tumor
progression.
Here,
the
malignant
characteristics
PC
effect
its
underlying
molecular
mechanism
carrying
were
investigated.
International Journal of Cancer,
Год журнала:
2024,
Номер
156(5), С. 898 - 913
Опубликована: Окт. 30, 2024
Exosomes
can
be
modified
and
designed
for
various
therapeutic
goals
because
of
their
unique
physical
chemical
characteristics.
Researchers
have
identified
tumor-derived
exosomes
(TEXs)
as
significant
players
in
cancer
by
influencing
tumor
growth,
immune
response
evasion,
angiogeneis,
drug
resistance.
TEXs
promote
the
production
specific
proteins
important
progression.
Due
to
easy
accessibility,
are
being
through
genetic,
delivery,
membrane,
system,
alterations
repurposed
vehicles
delivering
drugs
improve
treatment
outcomes.
In
complex
vivo
environment,
clustered
regularly
interspaced
short
palindromic
repeats
CRISPR-associated
protein
9
(CRISPR/Cas9)
system
encounters
challenges
from
degradation,
neutralization,
responses,
emphasizing
need
strategic
distribution
strategies
effective
genome
editing.
Engineered
present
a
promising
avenue
CRISPR/Cas9
vivo.
this
review,
we
will
explore
different
techniques
enhancing
using
engineering
strategies.
Additionally,
discuss
how
these
incorporated
into
advanced
genetic
systems
like
possible
uses.
Environmental Toxicology,
Год журнала:
2023,
Номер
38(12), С. 2857 - 2866
Опубликована: Сен. 4, 2023
Drug
resistance
is
a
considerable
obstacle
to
gastric
cancer
(GC)
treatment.
The
current
work
aimed
elucidate
the
functional
mechanism
of
CD109
in
5-fluorouracil
(5-FU)
GC.
In
this
study,
we
demonstrated
that
was
extremely
heightened
5-FU-resistant
GC
cells.
deficiency
lessened
IC50
value,
impaired
cell
viability
and
metastatic
capability,
induced
apoptosis
after
5-FU
treatment
addition,
found
PAX5
bound
p300
increased
enrichment
H3K27ac
at
promoter
region
gene,
which
resulted
upregulation
Moreover,
also
revealed
triggered
via
activating
JNK/MAPK
signaling.
Blockage
signaling
using
JNK
inhibitor,
SP600125,
abolished
upregulation-induced
changes
values,
viability,
metastasis
NCI-N87/5-FU
SNU-1/5-FU
Importantly,
silencing
enhanced
therapeutic
efficacy
5-FU,
leading
reduced
tumor
growth
vivo.
conclusion,
our
results
unveiled
H3K27
acetylation
activated-CD109
cells
modulating
pathway,
might
provide
an
attractive
target
for
