Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration DOI
Yue Wang, Xinyu Wang,

Yanyun Pang

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(34)

Опубликована: Март 10, 2024

Abstract Native bone inherently requires a balanced ionic microenvironment to maintain homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into defects hold great promise regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in process regeneration, impacting immunomodulation, angiogenesis, osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres developed as injectable microscaffolds (denoted GMN). GMN enables Mg/Si at an optimized ratio, achieving most significant synergistic effect on vascularized Various conditioned media obtained explore angiogenesis‐osteogenesis coupling, well crosstalk between marrow mesenchymal stromal cells (BMSCs) macrophages. Meanwhile, autocrine paracrine effects simultaneously modulating functions determining cell fates under guidance biofactors secreted by cells. Overall, ion‐engineering create conducive efficiently augment regeneration tissue vivo, offering versatile platform engineering.

Язык: Английский

Recent Advances in Stimuli-Responsive Metallogels DOI Creative Commons
Zhixiong Liu,

Xiaofang Zhao,

Qingkai Chu

и другие.

Molecules, Год журнала: 2023, Номер 28(5), С. 2274 - 2274

Опубликована: Фев. 28, 2023

Recently, stimuli-responsive supramolecular gels have received significant attention because their properties can be modulated through external stimuli such as heat, light, electricity, magnetic fields, mechanical stress, pH, ions, chemicals and enzymes. Among these gels, metallogels shown promising applications in material science of fascinating redox, optical, electronic properties. In this review, research progress on recent years is systematically summarized. According to stimulus sources, metallogels, including chemical, physical multiple are discussed separately. Moreover, challenges, suggestions opportunities regarding the development novel presented. We believe knowledge inspiration gained from review will deepen current understanding smart encourage more scientists provide valuable contributions topic coming decades.

Язык: Английский

Процитировано

26

Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis DOI Creative Commons
Senrui Liu, Shengwen Cheng, Bowen Chen

и другие.

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 15, 2023

Osteoarthritis (OA) is an age-related disease characterised by the accumulation of senescent chondrocytes, which drives its pathogenesis and progression. Senescent cells exhibit distinct features, including mitochondrial dysfunction excessive release reactive oxygen species (ROS), are highly correlated lead to a vicious cycle increasing cells. Stem cell therapy has proven effective in addressing cellular senescence, however, it still issues such as immune rejection ethical concerns. Microvesicles (MVs) constitute primary mechanism through stem exerts effects, offering cell-free approach that circumvents these risks excellent anti-ageing potential. Nonetheless, MVs have short vivo half-life, their secretion composition varies considerably under diverse conditions. This study aims address constructing ROS-responsive hydrogel loaded with pre-stimulant MVs. Through responding ROS levels this intelligently releases MVs, enhancing function chondrocytes improving senescence.We employed Interferon-gamma (IFN-γ) cell-specific stimulus generate IFN-γ-microvesicles (iMVs) enhanced effects. Simultaneously, we developed carrier utilising 3-aminophenylboronic acid (APBA)-modified silk fibroin (SF) polyvinyl alcohol (PVA). served protect prolong longevity, facilitate intelligent release. In vitro experiments demonstrated Hydrogel@iMVs effectively mitigated improved function, antioxidant capacity. further substantiated capabilities [email protected] effect can be significantly appropriate pre-stimulation suitable carrier. Therefore, containing IFN-γ pre-stimulated iMVs target characteristics ageing OA for therapeutic purposes. Overall, novel regulating balance between fission fusion, was reduced, finally, alleviates promising strategy OA.

Язык: Английский

Процитировано

26

Konjac glucomannan-based hydrogels with health-promoting effects for potential edible electronics applications: A mini-review DOI
William Xaveriano Waresindo, Aan Priyanto, Yuan Alfinsyah Sihombing

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 248, С. 125888 - 125888

Опубликована: Июль 19, 2023

Язык: Английский

Процитировано

25

Hydrogel and Nanomedicine‐Based Multimodal Therapeutic Strategies for Spinal Cord Injury DOI
Peng Yin, Weishi Liang, Bo Han

и другие.

Small Methods, Год журнала: 2023, Номер 8(1)

Опубликована: Окт. 26, 2023

Abstract Spinal cord injury (SCI) is a severe neurodegenerative disease caused by mechanical and biological factors, manifesting as loss of motor sensory functions. Inhibition expansion even reversal in the acute damage stage SCI are important strategies for treating this disease. Hydrogels nanoparticle (NP)‐based drugs most effective, widely studied, clinically valuable therapeutic field repair regeneration. 3D flow structures that fill pathological gaps provide microenvironment similar to spinal extracellular matrix nerve cell NP‐based can easily penetrate blood‐spinal barrier, target lesions, noninvasive. NPs drug carriers be loaded with various factors slow release lesions. They help function more efficiently exerting anti‐inflammatory, antioxidant, regeneration effects promote recovery neurological function. In review, use hydrogels role both discussed multimodal strategic reference after SCI.

Язык: Английский

Процитировано

25

Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration DOI
Yue Wang, Xinyu Wang,

Yanyun Pang

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(34)

Опубликована: Март 10, 2024

Abstract Native bone inherently requires a balanced ionic microenvironment to maintain homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into defects hold great promise regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in process regeneration, impacting immunomodulation, angiogenesis, osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres developed as injectable microscaffolds (denoted GMN). GMN enables Mg/Si at an optimized ratio, achieving most significant synergistic effect on vascularized Various conditioned media obtained explore angiogenesis‐osteogenesis coupling, well crosstalk between marrow mesenchymal stromal cells (BMSCs) macrophages. Meanwhile, autocrine paracrine effects simultaneously modulating functions determining cell fates under guidance biofactors secreted by cells. Overall, ion‐engineering create conducive efficiently augment regeneration tissue vivo, offering versatile platform engineering.

Язык: Английский

Процитировано

17