Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

Biomaterials Science, Год журнала: 2023, Номер 12(1), С. 8 - 56

Опубликована: Окт. 25, 2023

Hydrogels have established their significance as prominent biomaterials within the realm of biomedical research. However, injectable hydrogels garnered greater attention compared with conventional counterparts due to excellent minimally invasive nature and adaptive behavior post-injection. With rapid advancement emerging chemistry deepened understanding biological processes, contemporary been endowed an "intelligent" capacity respond various endogenous/exogenous stimuli (such temperature, pH, light magnetic field). This innovation has spearheaded revolutionary transformations across fields such tissue engineering repair, controlled drug delivery, disease-responsive therapies, beyond. In this review, we comprehensively expound upon raw materials (including natural synthetic materials) principles these advanced hydrogels, concurrently providing a detailed discussion prevalent strategies for conferring stimulus responsiveness. Finally, elucidate latest applications "smart" stimuli-responsive in domain, offering insights into prospects.

Язык: Английский

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Hydrogel and Nanomedicine‐Based Multimodal Therapeutic Strategies for Spinal Cord Injury

Small Methods, Год журнала: 2023, Номер 8(1)

Опубликована: Окт. 26, 2023

Abstract Spinal cord injury (SCI) is a severe neurodegenerative disease caused by mechanical and biological factors, manifesting as loss of motor sensory functions. Inhibition expansion even reversal in the acute damage stage SCI are important strategies for treating this disease. Hydrogels nanoparticle (NP)‐based drugs most effective, widely studied, clinically valuable therapeutic field repair regeneration. 3D flow structures that fill pathological gaps provide microenvironment similar to spinal extracellular matrix nerve cell NP‐based can easily penetrate blood‐spinal barrier, target lesions, noninvasive. NPs drug carriers be loaded with various factors slow release lesions. They help function more efficiently exerting anti‐inflammatory, antioxidant, regeneration effects promote recovery neurological function. In review, use hydrogels role both discussed multimodal strategic reference after SCI.

Язык: Английский

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Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 15, 2023

Osteoarthritis (OA) is an age-related disease characterised by the accumulation of senescent chondrocytes, which drives its pathogenesis and progression. Senescent cells exhibit distinct features, including mitochondrial dysfunction excessive release reactive oxygen species (ROS), are highly correlated lead to a vicious cycle increasing cells. Stem cell therapy has proven effective in addressing cellular senescence, however, it still issues such as immune rejection ethical concerns. Microvesicles (MVs) constitute primary mechanism through stem exerts effects, offering cell-free approach that circumvents these risks excellent anti-ageing potential. Nonetheless, MVs have short vivo half-life, their secretion composition varies considerably under diverse conditions. This study aims address constructing ROS-responsive hydrogel loaded with pre-stimulant MVs. Through responding ROS levels this intelligently releases MVs, enhancing function chondrocytes improving senescence.We employed Interferon-gamma (IFN-γ) cell-specific stimulus generate IFN-γ-microvesicles (iMVs) enhanced effects. Simultaneously, we developed carrier utilising 3-aminophenylboronic acid (APBA)-modified silk fibroin (SF) polyvinyl alcohol (PVA). served protect prolong longevity, facilitate intelligent release. In vitro experiments demonstrated Hydrogel@iMVs effectively mitigated improved function, antioxidant capacity. further substantiated capabilities [email protected] effect can be significantly appropriate pre-stimulation suitable carrier. Therefore, containing IFN-γ pre-stimulated iMVs target characteristics ageing OA for therapeutic purposes. Overall, novel regulating balance between fission fusion, was reduced, finally, alleviates promising strategy OA.

Язык: Английский

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Recent Advances in Stimuli-Responsive Metallogels

Molecules, Год журнала: 2023, Номер 28(5), С. 2274 - 2274

Опубликована: Фев. 28, 2023

Recently, stimuli-responsive supramolecular gels have received significant attention because their properties can be modulated through external stimuli such as heat, light, electricity, magnetic fields, mechanical stress, pH, ions, chemicals and enzymes. Among these gels, metallogels shown promising applications in material science of fascinating redox, optical, electronic properties. In this review, research progress on recent years is systematically summarized. According to stimulus sources, metallogels, including chemical, physical multiple are discussed separately. Moreover, challenges, suggestions opportunities regarding the development novel presented. We believe knowledge inspiration gained from review will deepen current understanding smart encourage more scientists provide valuable contributions topic coming decades.

Язык: Английский

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Konjac glucomannan-based hydrogels with health-promoting effects for potential edible electronics applications: A mini-review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 248, С. 125888 - 125888

Опубликована: Июль 19, 2023

Язык: Английский

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