Advanced Functional Materials,
Год журнала:
2024,
Номер
34(34)
Опубликована: Март 10, 2024
Abstract
Native
bone
inherently
requires
a
balanced
ionic
microenvironment
to
maintain
homeostasis.
Hence,
scaffolds
designed
for
the
sustained
release
of
therapeutic
ions
into
defects
hold
great
promise
regeneration.
Magnesium
(Mg)
and
silicon
(Si)
are
essential
elements,
which
play
crucial
roles
in
process
regeneration,
impacting
immunomodulation,
angiogenesis,
osteogenesis.
Herein,
porous
cryogel‐type
organic–inorganic
composite
microspheres
developed
as
injectable
microscaffolds
(denoted
GMN).
GMN
enables
Mg/Si
at
an
optimized
ratio,
achieving
most
significant
synergistic
effect
on
vascularized
Various
conditioned
media
obtained
explore
angiogenesis‐osteogenesis
coupling,
well
crosstalk
between
marrow
mesenchymal
stromal
cells
(BMSCs)
macrophages.
Meanwhile,
autocrine
paracrine
effects
simultaneously
modulating
functions
determining
cell
fates
under
guidance
biofactors
secreted
by
cells.
Overall,
ion‐engineering
create
conducive
efficiently
augment
regeneration
tissue
vivo,
offering
versatile
platform
engineering.
Molecules,
Год журнала:
2023,
Номер
28(5), С. 2274 - 2274
Опубликована: Фев. 28, 2023
Recently,
stimuli-responsive
supramolecular
gels
have
received
significant
attention
because
their
properties
can
be
modulated
through
external
stimuli
such
as
heat,
light,
electricity,
magnetic
fields,
mechanical
stress,
pH,
ions,
chemicals
and
enzymes.
Among
these
gels,
metallogels
shown
promising
applications
in
material
science
of
fascinating
redox,
optical,
electronic
properties.
In
this
review,
research
progress
on
recent
years
is
systematically
summarized.
According
to
stimulus
sources,
metallogels,
including
chemical,
physical
multiple
are
discussed
separately.
Moreover,
challenges,
suggestions
opportunities
regarding
the
development
novel
presented.
We
believe
knowledge
inspiration
gained
from
review
will
deepen
current
understanding
smart
encourage
more
scientists
provide
valuable
contributions
topic
coming
decades.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 15, 2023
Osteoarthritis
(OA)
is
an
age-related
disease
characterised
by
the
accumulation
of
senescent
chondrocytes,
which
drives
its
pathogenesis
and
progression.
Senescent
cells
exhibit
distinct
features,
including
mitochondrial
dysfunction
excessive
release
reactive
oxygen
species
(ROS),
are
highly
correlated
lead
to
a
vicious
cycle
increasing
cells.
Stem
cell
therapy
has
proven
effective
in
addressing
cellular
senescence,
however,
it
still
issues
such
as
immune
rejection
ethical
concerns.
Microvesicles
(MVs)
constitute
primary
mechanism
through
stem
exerts
effects,
offering
cell-free
approach
that
circumvents
these
risks
excellent
anti-ageing
potential.
Nonetheless,
MVs
have
short
vivo
half-life,
their
secretion
composition
varies
considerably
under
diverse
conditions.
This
study
aims
address
constructing
ROS-responsive
hydrogel
loaded
with
pre-stimulant
MVs.
Through
responding
ROS
levels
this
intelligently
releases
MVs,
enhancing
function
chondrocytes
improving
senescence.We
employed
Interferon-gamma
(IFN-γ)
cell-specific
stimulus
generate
IFN-γ-microvesicles
(iMVs)
enhanced
effects.
Simultaneously,
we
developed
carrier
utilising
3-aminophenylboronic
acid
(APBA)-modified
silk
fibroin
(SF)
polyvinyl
alcohol
(PVA).
served
protect
prolong
longevity,
facilitate
intelligent
release.
In
vitro
experiments
demonstrated
Hydrogel@iMVs
effectively
mitigated
improved
function,
antioxidant
capacity.
further
substantiated
capabilities
[email protected]
effect
can
be
significantly
appropriate
pre-stimulation
suitable
carrier.
Therefore,
containing
IFN-γ
pre-stimulated
iMVs
target
characteristics
ageing
OA
for
therapeutic
purposes.
Overall,
novel
regulating
balance
between
fission
fusion,
was
reduced,
finally,
alleviates
promising
strategy
OA.
Abstract
Spinal
cord
injury
(SCI)
is
a
severe
neurodegenerative
disease
caused
by
mechanical
and
biological
factors,
manifesting
as
loss
of
motor
sensory
functions.
Inhibition
expansion
even
reversal
in
the
acute
damage
stage
SCI
are
important
strategies
for
treating
this
disease.
Hydrogels
nanoparticle
(NP)‐based
drugs
most
effective,
widely
studied,
clinically
valuable
therapeutic
field
repair
regeneration.
3D
flow
structures
that
fill
pathological
gaps
provide
microenvironment
similar
to
spinal
extracellular
matrix
nerve
cell
NP‐based
can
easily
penetrate
blood‐spinal
barrier,
target
lesions,
noninvasive.
NPs
drug
carriers
be
loaded
with
various
factors
slow
release
lesions.
They
help
function
more
efficiently
exerting
anti‐inflammatory,
antioxidant,
regeneration
effects
promote
recovery
neurological
function.
In
review,
use
hydrogels
role
both
discussed
multimodal
strategic
reference
after
SCI.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(34)
Опубликована: Март 10, 2024
Abstract
Native
bone
inherently
requires
a
balanced
ionic
microenvironment
to
maintain
homeostasis.
Hence,
scaffolds
designed
for
the
sustained
release
of
therapeutic
ions
into
defects
hold
great
promise
regeneration.
Magnesium
(Mg)
and
silicon
(Si)
are
essential
elements,
which
play
crucial
roles
in
process
regeneration,
impacting
immunomodulation,
angiogenesis,
osteogenesis.
Herein,
porous
cryogel‐type
organic–inorganic
composite
microspheres
developed
as
injectable
microscaffolds
(denoted
GMN).
GMN
enables
Mg/Si
at
an
optimized
ratio,
achieving
most
significant
synergistic
effect
on
vascularized
Various
conditioned
media
obtained
explore
angiogenesis‐osteogenesis
coupling,
well
crosstalk
between
marrow
mesenchymal
stromal
cells
(BMSCs)
macrophages.
Meanwhile,
autocrine
paracrine
effects
simultaneously
modulating
functions
determining
cell
fates
under
guidance
biofactors
secreted
by
cells.
Overall,
ion‐engineering
create
conducive
efficiently
augment
regeneration
tissue
vivo,
offering
versatile
platform
engineering.
