New Journal of Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Hydrogel films were prepared using mucoadhesive extracts from fenugreek and flax seeds, their versatility for a range of biological uses – such as anti-inflammatory, anti-diabetic, anti-oxidant, anti-microbial applications was examined.
Язык: Английский
Discover Materials, Год журнала: 2025, Номер 5(1)
Опубликована: Янв. 9, 2025
Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.
Язык: Английский
Процитировано
7
Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 215 - 215
Опубликована: Фев. 7, 2025
Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability difficulties in ensuring patient adherence. These challenges have driven the development of advanced systems (DDS), with hydrogels especially nanogels emerging as promising materials overcome these limitations. Hydrogels, their biocompatibility, high water content, stimuli-responsive properties, provide controlled targeted release. This review explores evolution, classifications versus applications delivery, detailing synthesis methods, chemical crosslinking, physical self-assembly, techniques such microfluidics 3D printing. It also examines drug-loading mechanisms (e.g., encapsulation electrostatic interactions) release strategies diffusion, stimuli-responsive, enzyme-triggered). gels demonstrate significant advantages addressing limitations traditional DDS, offering improved stability, sustained release, specificity. Their adaptability extends various routes administration, topical, oral, injectable forms, while further enhance targeting through nanoscale precision stimuli responsiveness. Although transformative potential personalized medicine, remain scalable manufacturing, regulatory approval, delivery. Future include integrating biosensors for real-time monitoring, developing dual-stimuli-responsive systems, optimizing surface functionalization advancements aim establish cornerstones next-generation solutions, revolutionizing paving way innovative, patient-centered treatments.
Язык: Английский
Процитировано
5
Macromolecular Rapid Communications, Год журнала: 2024, Номер 45(11)
Опубликована: Фев. 24, 2024
Abstract Hydrogels, key in biomedical research for their hydrophilicity and versatility, have evolved with hydrogel microspheres (HMs) of micron‐scale dimensions, enhancing role minimally invasive therapeutic delivery, tissue repair, regeneration. The recent emergence nanomaterials has ushered a revolutionary transformation the field, which demonstrates tremendous potential targeted therapies, biological imaging, disease diagnostics. Consequently, integration advanced nanotechnology promises to trigger new revolution realm hydrogels. HMs loaded combine advantages both hydrogels nanomaterials, enables multifaceted functionalities such as efficient drug sustained release, therapy, lubrication, biochemical detection, medical biosensing monitoring, micro‐robotics. Here, this review comprehensively expounds upon commonly used classifications. Then, it provides comprehensive insights into raw materials preparation methods HMs. Besides, common strategies employed achieve nano‐micron combinations are summarized, latest applications these combined field elucidated. Finally, valuable future design development provided.
Язык: Английский
Процитировано
10
Small Methods, Год журнала: 2024, Номер unknown
Опубликована: Май 19, 2024
Organ-on-a-chip, also known as "tissue chip," is an advanced platform based on microfluidic systems for constructing miniature organ models in vitro. They can replicate the complex physiological and pathological responses of human organs. In recent years, development bone joint-on-chip platforms aims to simulate processes occurring bones joints, including cell-cell interactions, interplay various biochemical factors, effects mechanical stimuli, intricate connections between multiple future, will integrate advantages disciplines, bringing more possibilities exploring disease mechanisms, drug screening, personalized medicine. This review explores construction application Organ-on-a-chip technology joint research, proposes a modular concept, discusses new opportunities future challenges platforms.
Язык: Английский
Процитировано
6
Industrial Crops and Products, Год журнала: 2025, Номер 225, С. 120513 - 120513
Опубликована: Янв. 16, 2025
Язык: Английский
Процитировано
0
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(4)
Опубликована: Апрель 1, 2025
ABSTRACT The rapid advancement of digital technologies has heightened the demand for multifunctional smart materials with adaptive and responsive capabilities. Among these, chromogenic hydrogel composites have emerged as promising candidates next‐generation applications due to their unique stimuli‐responsive behavior. These hydrogels exhibit dynamic optical changes in response external triggers such light, temperature, pH, humidity, mechanical stress, electric or magnetic fields, enabling a wide range functionalities data storage, security, authentication, anti‐counterfeiting technologies. This review provides comprehensive examination composites, focusing on fundamental design principles, mechanisms, emerging systems. categorizes these based response, including photochromic, hydrochromic, electrochromic, magnetochromic, thermochromic, tribochromic, mechanochromic systems, analyzing key material compositions functional characteristics. Furthermore, recent advances fabrication techniques 3D 4D printing, self‐healing networks, multi‐stimuli‐responsive are discussed, highlighting potential programmable displays, rewritable encrypted security Finally, identifies current challenges future directions field, emphasizing need enhanced durability, faster times, improved integration insights presented this work aim guide development innovative interactive intelligent materials.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137209 - 137209
Опубликована: Ноя. 4, 2024
Язык: Английский
Процитировано
4
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Injectable biomaterials play a vital role in modern medicine, offering tailored functionalities for diverse therapeutic and diagnostic applications. In ophthalmology, instance, viscoelastic materials are crucial procedures such as cataract surgery but often leave residues, increasing postoperative risks. This study introduces injectable fluorescent viscoelastics (FluoVs) synthesized via one-step controlled radical copolymerization of oligo(ethylene glycol) acrylate fluorescein acrylate. These bottlebrush-shaped polymers exhibit enhanced fluorescence intensity improved traceability facile removal postsurgery. To prevent aggregation, charged terpolymers were synthesized, ensuring intra- intermolecular electrostatic repulsion. Dynamic light scattering energy-conserved dissipative particle dynamics simulations revealed how the content monomer sequence affect hydrodynamic size these copolymers. Biocompatibility assessments showed that FluoVs maintained cell viability comparable to commercial hydroxypropyl methylcellulose nonfluorescent poly(oligo(ethylene acrylate) controls. The combine high intensity, low viscosity, excellent biocompatibility, intraoperative significant advancements ocular bioimaging
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160620 - 160620
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(2), С. 131 - 131
Опубликована: Фев. 12, 2025
Local anesthetics (LAs) have been indispensable in clinical pain management, yet their limitations, such as short duration of action and systemic toxicity, necessitate improved delivery strategies. Hydrogels, with biocompatibility, tunable properties, ability to modulate drug release, extensively explored platforms for enhancing LA efficacy safety. This narrative review explores the historical development LAs, physicochemical applications, providing a foundation understanding integration hydrogels anesthetic delivery. Advances thermoresponsive, stimuli-responsive, multifunctional demonstrated significant potential prolonging analgesia reducing exposure preclinical studies, while early findings highlight feasibility thermoresponsive hydrogel formulations. Despite these advancements, challenges burst mechanical instability, regulatory considerations remain critical barriers translation. Emerging innovations, including nanocomposite hydrogels, biofunctionalized matrices, smart materials, offer solutions limitations. Future research should focus on optimizing formulations, expanding validation, integrating advanced fabrication technologies 3D printing artificial intelligence-driven design enhance personalized management. By bridging materials science pharmacology, this provides comprehensive perspective current trends future directions hydrogel-based systems.
Язык: Английский
Процитировано
0