Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 15, 2024

With increasing proportion of the elderly in population, age-related diseases (ARD) lead to a considerable healthcare burden society. Prevention and treatment ARD can decrease negative impact aging disease. The rate is closely associated with production high levels reactive oxygen species (ROS). ROS-mediated oxidative stress triggers aging-related changes through lipid peroxidation, protein oxidation, DNA oxidation. Antioxidants control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing stress. Benefiting from significant advances nanotechnology, large number nanomaterials ROS-scavenging capabilities have been developed. be divided into two categories: as carriers for delivering drugs, themselves activity. This study summarizes current prevention ARD, highlights potential mechanisms used discusses challenges prospects applications.

Язык: Английский

Nanomaterials for Targeted Therapy of Kidney Diseases: Strategies and Advances

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101534 - 101534

Опубликована: Янв. 29, 2025

The treatment and management of kidney diseases pose a significant global burden. Due to the presence blood circulation barriers glomerular filtration barriers, drug therapy for faces challenges such as poor renal targeting, short half-life, severe systemic side effects, severely hindering therapeutic progress. Therefore, research development kidney-targeted agents is great clinical significance. In recent years, application nanotechnology in field nephrology has shown potential revolutionizing diagnosis diseases. Carefully designed nanomaterials can exhibit optimal biological characteristics, influencing various aspects circulation, retention, excretion. Rationally designing modifying based on anatomical structure pathophysiological environment achieve highly specific or nanodrug delivery systems both feasible promising. Based targeted diseases, this review discusses advantages limitations current nanomedicine summarizes active/passive targeting strategies, order further promote through preliminary summary previous studies future prospects.

Язык: Английский

Integration of Melanin-Resveratrol Nanosystem for the Diagnostic-therapeutic of Renal Fibrosis

Chemical Research in Chinese Universities, Год журнала: 2024, Номер unknown

Опубликована: Окт. 2, 2024

Язык: Английский