Biomarkers in Neuropsychiatry, Год журнала: 2025, Номер 12, С. 100122 - 100122
Опубликована: Фев. 1, 2025
Язык: Английский
Neuron, Год журнала: 2024, Номер 112(12), С. 1911 - 1929
Опубликована: Май 24, 2024
Язык: Английский
Процитировано
27
World Psychiatry, Год журнала: 2024, Номер 23(2), С. 215 - 232
Опубликована: Май 10, 2024
Work at the intersection of philosophy and psychiatry has an extensive influential history, received increased attention recently, with emergence professional associations a growing literature. In this paper, we review key advances in work on psychiatry, their related clinical implications. First, understanding categorizing mental disorder, both naturalist normativist considerations are now viewed as important – psychiatric constructs necessitate consideration facts values. At conceptual level, integrative view encourages moving away from strict scientism to soft naturalism, while practice facilitates evidence‐based values‐based health care. Second, considering nature science, there is increasing emphasis pluralist approach, including ontological, explanatory value pluralism. Conceptually, approach acknowledges multi‐level causal interactions that give rise psychopathology, clinically it emphasizes importance broad range “difference‐makers”, well “lived experience” research practice. Third, questions about brain‐mind, how somatic psychic factors contribute development maintenance disorders, empirical embodied cognition provides increasingly valuable approach. Viewing brain‐mind embodied, embedded enactive offers mind‐body problem integration cognitive‐affective neuroscience phenomenological psychopathology.
Язык: Английский
Процитировано
21
World Psychiatry, Год журнала: 2025, Номер 24(1), С. 52 - 80
Опубликована: Янв. 15, 2025
The understanding of responses to traumatic events has been greatly influenced by the introduction diagnosis post‐traumatic stress disorder (PTSD). In this paper we review initial versions diagnostic criteria for condition and associated epidemiological findings, including sociocultural differences. We consider evidence reactions occurring in multiple contexts not previously defined as traumatic, implications that these observations have diagnosis. More recent developments such DSM‐5 dissociative subtype ICD‐11 complex PTSD are reviewed, adding there several distinct phenotypes. describe psychological foundations PTSD, involving disturbances memory well identity. A broader focus on identity may be able accommodate group communal influences experience trauma impact resource loss. then summarize current concerning biological with a particular genetic neuroimaging studies. Whereas progress prevention disappointing, is now an extensive supporting efficacy variety treatments established trauma‐focused interventions – cognitive behavior therapy (TF‐CBT) eye movement desensitization reprocessing (EMDR) non‐trauma‐focused therapies, which also include some emerging identity‐based approaches present‐centered compassion‐focused therapies. Additionally, promising neither nor pharmacological, or combine pharmacological approach, 3,4‐methylenedioxymethamphetamine (MDMA)‐assisted psychotherapy. advances priority areas adapting resource‐limited settings across cultural contexts, community‐based approaches. conclude identifying future directions work mental health.
Язык: Английский
Процитировано
9
Nature Human Behaviour, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
2
Journal of Internal Medicine, Год журнала: 2023, Номер 294(4), С. 378 - 396
Опубликована: Апрель 24, 2023
Complex diseases are caused by a combination of genetic, lifestyle, and environmental factors comprise common noncommunicable diseases, including allergies, cardiovascular disease, psychiatric metabolic disorders. More than 25% Europeans suffer from complex together these account for 70% all deaths. The use genomic, molecular, or imaging data to develop accurate diagnostic tools treatment recommendations preventive strategies, disease prognosis prediction, is an important step toward precision medicine. However, medicine associated with several challenges. There significant heterogeneity between patients specific disease-both regards symptoms underlying causal mechanisms-and the number genetic nongenetic risk often high. Here, we summarize approaches highlight current breakthroughs as well We conclude that genomic-based has been used mainly highly penetrant monogenic forms, such cardiomyopathies. most diseases-including disorders allergies-available polygenic scores more probabilistic deterministic have not yet validated clinical utility. subclassifying into discrete homogenous subtypes based on molecular phenotypic promising strategy improving diagnosis, treatment, prevention, prognosis. availability high-throughput technologies, large collections health novel data-driven approaches, offers promise improved individual through
Язык: Английский
Процитировано
34
Genome Medicine, Год журнала: 2023, Номер 15(1)
Опубликована: Авг. 1, 2023
Abstract Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability remains unidentified, overlap somatic disorders is not quantified beyond correlations. Here, we characterize architecture IBS, further, investigate its phenotypes, identify novel genomic loci. Methods Using GWAS summary statistics IBS (53,400 cases 433,201 controls), performed bivariate casual mixture model analysis to between these phenotypes. We leveraged boost discovery loci associated specific shared both using conditional/conjunctional false rate (condFDR/conjFDR) framework. used functional mapping gene annotation (FUMA) analyses. Results was highly polygenic 12k trait-influencing variants. found extensive a lesser extent diseases. 132 independent IBS-associated (condFDR < 0.05) by conditioning on ( n = 127) diseases 24). conjFDR, 70 unique were Functional analyses revealed enrichment biological pathways nervous immune systems. Genetic correlations subtypes different. Conclusions phenotypes what Leveraging overlap, discovered which implicate wide range gut-brain axis. differences may underlie clinical subtype These results increase our understanding pathophysiology form basis development individualized interventions.
Язык: Английский
Процитировано
24
Biological Psychiatry, Год журнала: 2024, Номер 96(7), С. 543 - 551
Опубликована: Янв. 5, 2024
Precision medicine has the ambition to improve treatment response and clinical outcomes through patient stratification, holds great potential in mental disorders. However, several important factors are needed transform current practice into a "precision psychiatry" framework. Most (1) generation of accessible large real-world training test data including genomic integrated from multiple sources, (2) development validation advanced analytical tools for stratification prediction, (3) clinically useful management platforms monitoring that can be healthcare systems real-life settings. This narrative review summarizes strategies obtaining key elements – well-powered samples biobanks, with electronic health records registry using novel artificial intelligence algorithms predict severe disorders translate these models approaches. Key massive algorithms. For translation strategies, we discuss precision platform improved We include use cases illustrate how interventions could brought psychiatry
Язык: Английский
Процитировано
12
Journal of Psychosomatic Research, Год журнала: 2024, Номер 178, С. 111599 - 111599
Опубликована: Янв. 30, 2024
Язык: Английский
Процитировано
12
Asian Journal of Psychiatry, Год журнала: 2024, Номер 98, С. 104105 - 104105
Опубликована: Июнь 5, 2024
Although there is considerable evidence showing that the prevention of mental illnesses and adverse outcomes health promotion can help people lead better more functional lives, public overlooked in broader contexts psychiatry health. Likewise, undergraduate postgraduate medical curricula, have often been ignored. However, has a recent increase interest health, including an emphasis on psychiatric disorders improving individual community wellbeing to support life trajectories, from childhood through adulthood into older age. These lifespan approaches significant potential reduce onset related burdens for communities, as well mitigating social, economic, political costs. Informed by principles social justice respect human rights, this may be especially important addressing salient problems communities with distinct vulnerabilities, where prominent disadvantages barriers care delivery exist. Therefore, Commission aims address these topics, providing narrative review relevant literature suggesting ways forward. Additionally, proposals preventing are presented, particularly amongst at-risk populations.
Язык: Английский
Процитировано
8
Biological Psychiatry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Early in life, behavioral and cognitive traits associated with risk for developing a psychiatric condition are broad undifferentiated. As children develop, these differentiate into characteristic clusters of symptoms behaviors that ultimately form the basis diagnostic categories. Understanding this differentiation process - context genetic conditions, which is highly generalized can improve early detection intervention. We modeled emotional problems from age 1.5-5 years (behavioral = score) pre-registered study ∼79,000 population-based Norwegian Mother, Father, Child Cohort Study. used genomic structural equation modeling to identify signal total problems, investigating their links 11 neurodevelopmental conditions. examined associations polygenic scores (PGS) both outcomes assessed relative contributions direct indirect effects ∼33,000 family trios. Differentiation was primarily genetically correlated conditions via "neurodevelopmental" factor. Total were factor "p"-factor. PGS analyses revealed an association between liability ADHD (β=0.11 [0.10,0.12]), weaker (β=0.06 [0.04,0.07]). Trio-PGS showed predominantly on outcomes. uncovered process, mostly related common variants Investigating life may enhance our understanding developmental emergence different
Язык: Английский
Процитировано
1