Quercetin-primed BMSC-derived extracellular vesicles ameliorate chronic liver damage through miR-136-5p and GNAS/STAT3 signaling pathways
Xiaodan Jiang,
Zhejun Liu,
Hongjie You
и другие.
International Immunopharmacology,
Год журнала:
2024,
Номер
142, С. 113162 - 113162
Опубликована: Сен. 27, 2024
Язык: Английский
EHR-Based Risk Prediction for Kidney Cancer
Quality Management in Health Care,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Background
and
Objectives:
The
U.S.
Preventive
Services
Task
Force
(USPSTF)
does
not
currently
recommend
routine
screening
for
kidney
cancer,
even
though
approximately
14
390
people
are
expected
to
die
from
this
disease
in
the
United
States
2024.
Individualized
risk-based
cancer
offers
potential
effectively
detect
at
an
early
stage
avoid
unnecessarily
rest
of
population
who
low
risk.
This
study
proposes
electronic
health
records
(EHR)
risk
evaluation
by
examining
a
comprehensive
set
medical
history
including
diagnoses,
comorbidities,
viruses,
rare
diseases.
Methods:
relevant
predicting
occurrence
was
identified
analysis
All
Us
data
three
steps.
First,
Systematized
Nomenclature
Medicine
(SNOMED)
code
binary
indicator
variable
EHR
presence
cancer.
Second,
relationship
between
all
prior
conditions
examined
using
Strong
Rule
Feature
Elimination
Least
Absolute
Shrinkage
Selection
Operator
logistic
regression
methods
selection.
Third,
accuracy
model
reported
cross-validated
McFadden’s
R
2
Area
under
Receiver
Operating
Characteristic
curve
(AROC)
values.
Results:
133
out
initial
25
683
clinical
diagnoses
(represented
SNOMED
codes)
that
were
predictive
achieved
0.195
AROC
0.799.
Most
codes
consistent
with
known
factors
Conclusions:
It
is
possible
accurately
predict
method.
Additional
studies
establish
high-dimensional
needed
see
if
personalized
prediction
can
lead
cost-effective
eventually
better
outcomes.
Язык: Английский
Monocyte and Macrophage Functions in Oncogenic Viral Infections
Viruses,
Год журнала:
2024,
Номер
16(10), С. 1612 - 1612
Опубликована: Окт. 15, 2024
Monocytes
and
macrophages
are
part
of
innate
immunity
constitute
the
first
line
defense
against
pathogens.
Bone
marrow-derived
monocytes
circulate
in
bloodstream
for
one
to
three
days
then
typically
migrate
into
tissues,
where
they
differentiate
macrophages.
Circulatory
represent
5%
nucleated
cells
normal
adult
blood.
Following
differentiation,
distributed
various
tissues
organs
take
residence
maintain
body
homeostasis.
Emerging
evidence
has
highlighted
critical
role
monocytes/macrophages
oncogenic
viral
infections,
mainly
their
crucial
functions
persistence
disease
progression.
These
findings
open
opportunities
target
context
viruses
explore
potential
as
immunotherapies.
Язык: Английский
Evaluation of Some Hematological Parameters in HCV Infected Patients Among Blood Donors at Thi-Qar Province
Ahmed Hieran Ramadhan Al-Jabery,
Hayder Fadhil Okab,
Ali Obeid Ibrahim Alkafaji
и другие.
Academia Open,
Год журнала:
2024,
Номер
9(2)
Опубликована: Дек. 13, 2024
Hepatitis
C
virus
is
a
major
health
problem
because
of
its
effect
on
the
liver
and
being
life-threatening
if
not
treated
early.
It
also
affects
blood
parameters
those
infected.
The
current
study
conducted
in
Thi-Qar
province
revealed
changes
some
infected
group
compared
to
control
group,
where
slight
decrease
was
recorded
WBCs,
RBCs,
PCV,
MCV,
MCH,
PLT,
Lymp.
but
no
significant
differences
were
found,
except
for
red
cells,
which
0.03
at
level
0.05.
found
that
highest
infection
rate
age
30-39
years,
while
50-59
years.
Highlights:
impacts
alters
parameters.
Significant
RBC
change
noted;
30–39
group.
No
infections
50–59
recorded.
Keywords:
HCV,
Hematological,
ELISA,
Язык: Английский