The Importance of Including Maternal Immune Activation in Animal Models of Hypoxic–Ischemic Encephalopathy DOI Creative Commons

Bailey Collins,

Elise Lemanski,

Elizabeth C. Wright-Jin

и другие.

Biomedicines, Год журнала: 2024, Номер 12(11), С. 2559 - 2559

Опубликована: Ноя. 8, 2024

Hypoxic-ischemic encephalopathy (HIE) is a perinatal brain injury that the leading cause of cerebral palsy, developmental delay, and poor cognitive outcomes in children born at term, occurring about 1.5 out 1000 births. The only proven therapy for HIE therapeutic hypothermia. However, despite this treatment, many ultimately suffer disability, injury, even death. Barriers to implementation including late diagnosis lack resources also lead poorer outcomes. This demonstrates critical need additional treatments HIE, facilitate this, we translational models accurately reflect risk factors interactions present HIE. Maternal or amniotic infection significant factor possible humans. immune activation (MIA) well-established model maternal inflammation has consequences largely characterized within context neurodevelopmental disorders such as autism spectrum disorder schizophrenia. MIA can long-lasting changes neuroimmune system, which compounding negative following second insult. supports importance understanding interaction hypoxic-ischemic Animal have been invaluable pathophysiology development each system its own limitations. Large animal pigs may more represent organ complexity humans, while rodent are cost-effective offer molecular techniques. Recent studies utilized direct prior Investigators should thoughtfully consider they wish include their models. In incorporation MIA, investigators type, timing, dose inflammatory stimulus, well severity, type hypoxic Using variety incorporate maternal-placental-fetal will most likely robust mechanisms guide future clinical decisions therapies.

Язык: Английский

Sex and gender in neurodevelopmental conditions DOI
Sven Bölte, Janina Neufeld, Peter B. Marschik

и другие.

Nature Reviews Neurology, Год журнала: 2023, Номер 19(3), С. 136 - 159

Опубликована: Фев. 6, 2023

Язык: Английский

Процитировано

129
Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in human and rodent studies DOI Creative Commons
Mary Beth Hall, Daria E. Willis,

Elina L. Rodriguez

и другие.

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Апрель 13, 2023

Epidemiological evidence suggests that one’s risk of being diagnosed with a neurodevelopmental disorder (NDD)—such as autism, ADHD, or schizophrenia—increases significantly if their mother had viral bacterial infection during the first second trimester pregnancy. Despite this well-known data, little is known about how developing neural systems are perturbed by events such early-life immune activation. One theory maternal response disrupts processes important for typical fetal and postnatal development, which can subsequently result in specific overlapping behavioral phenotypes offspring, characteristic NDDs. As such, rodent models activation (MIA) have been useful elucidating mechanisms may become dysregulated MIA. This review will start an up-to-date in-depth, critical summary epidemiological data humans, examining association between different types MIA NDD outcomes offspring. Thereafter, we summarize common discuss relevance to human data. Finally, highlight other factors interact impact its associated NDDs, emphasize importance researchers consider these when designing future studies. These points include: sex developmental timing challenge, contribute individual variability responses MIA, genetics, parental age, gut microbiome, prenatal stress, placental buffering.

Язык: Английский

Процитировано

52
Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring DOI Creative Commons

Merve Denizli,

Maegan L. Capitano, Kok Lim Kua

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Сен. 16, 2022

The prevalence of obesity is increasingly common in the United States, with ~25% women reproductive age being overweight or obese. Metaflammation, a chronic low grade inflammatory state caused by altered metabolism, often present pregnancies complicated obesity. As result, fetuses mothers who are obese exposed to an in-utero environment that has nutrients and cytokines. Notably, both human preclinical studies have shown children born higher risks developing illnesses affecting various organ systems. In this review, authors sought role cytokines inflammation during healthy pregnancy determine how maternal changes landscape mother, leading fetal reprogramming. Next, negative long-term impact on offspring’s health numerous disease contexts, including risk neuropsychiatric disorders (autism, attention deficit hyperactive disorder), metabolic diseases (obesity, type 2 diabetes), atopy, malignancies will be discussed along potential immune/inflammatory status offspring as contributor these diseases. Finally, list critical knowledge gaps field developmental programming context obesity, particularly understudied hematopoietic stem progenitor cells.

Язык: Английский

Процитировано

60
Peripheral Inflammatory Markers in Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder at Adolescent Age DOI Open Access
Nikola Ferencová, Zuzana Višňovcová, Igor Ondrejka

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11710 - 11710

Опубликована: Июль 20, 2023

Autism spectrum disorder (ASD) and attention deficit/hyperactivity (ADHD) are associated with immune dysregulation. We aimed to estimate the pro- anti-inflammatory activity/balance in ASD ADHD patients at a little-studied adolescent age respect sex. evaluated 20 (5 girls, average age: 12.4 ± 1.9 y), 13.4 1.8 age- gender-matched controls (average 13.2 y). The parameters included (1) white blood cells (WBCs), neutrophils, monocytes, lymphocytes, platelets, platelet distribution width (PDW), mean volume, derived ratios, as well (2) cytokines-interferon-gamma, interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), profiles ratios. adolescents showed higher levels of WBC, IL-1α, macrophages (M)1 profile, profile than controls, males showing IL-6 lower T-helper (Th)1/Th2+T-regulatory cell ratio control males. PDW, IL-1β TNF-α, M1 proinflammatory pro-/anti-inflammatory females TNF-α Immune dysregulation appeared be different for both neurodevelopmental disorders adolescence.

Язык: Английский

Процитировано

31
Where Sex Meets Gender: How Sex and Gender Come Together to Cause Sex Differences in Mental Illness DOI Creative Commons
Dorte M. Christiansen, Margaret M. McCarthy, Mary V. Seeman

и другие.

Frontiers in Psychiatry, Год журнала: 2022, Номер 13

Опубликована: Июнь 28, 2022

Sex differences are prevalent in multiple mental disorders. Internalizing disorders more commonly diagnosed women, whereas externalizing and neurodevelopmental often men. Significant sex/gender reported prevalence, symptom profile, age of onset, comorbidities, functional impairment, prognosis, as well responses to various treatments. In this conceptual article, we discuss theories empirical studies sex- gender-related influences health, by focusing on three examples: autism spectrum disorder (ASD), acknowledged a whose roots mainly biological; eating disorders, origins considered be psychosocial, posttraumatic stress (PTSD), an environmentally caused with both psychosocial biological underpinnings. We examine the ways which sex emerge, from conception through adulthood. also how gender dichotomies exposures, expectations, role assumptions, cultural traditions impact expression our selected illnesses. especially interested sex-based gender-based interact one another affect illness. suggest that multi-faceted complex phenomena result variations, not only between men but within each alterations genes, hormone levels, self-perceptions, trauma experiences, interpersonal relationships. Finally, propose diatheses-stress model, depicting come together across categorize diatheses into several categories: biological, intrapersonal, interpersonal, environmental. These exposure stressors, ranging relatively minor traumatic, allows for sometimes bidirectional acute long-term responses. discussed at every level thereby providing framework understanding predicting expression, prevalence treatment response encourage research important field study.

Язык: Английский

Процитировано

33
Association between type 2 inflammatory diseases and neurodevelopmental disorders in low-birth-weight children and adolescents DOI Creative Commons

Hengye Huang,

Kelvin Pengyuan Zhang,

Karol Kexin Sun

и другие.

Frontiers in Psychology, Год журнала: 2024, Номер 15

Опубликована: Фев. 22, 2024

Evidence of the association certain neurodevelopmental disorder with specific type 2 inflammatory (T2) disease has been found. However, various disorders T2 diseases as a whole remains unclear in low-birth-weight (LBW) infants. To evaluate intellectual disability (ID), autism spectrum (ASD), attention deficit hyperactivity (ADHD), and learning (LD) LBW children adolescents. The study sample was derived from 2005 to 2018 National Health Interview Survey child files. adolescents aged 3-17 were included. History (including asthma atopic dermatitis) four reported by adults families. relationship between risk investigated through multiple-weighted logistic regression. Age, sex, race/ethnicity, region, highest education family ratio income poverty threshold adjusted covariates for model estimation. Subgroup analyses conducted age stratification (3-11 12-17 years), sex (male female), race (white non-white). 11,260 years [mean (SE), 9.73 (0.05) years] included, which 3,191 had diseases. associated an increased disorders, OR 1.35 (95% CI, 0.99-1.84) ID, 1.47 1.05-2.05) ASD, 1.81 1.51-2.16) ADHD, 1.74 1.49-2.04) LD following adjustment all covariates. correlations each significantly different (all P interaction < 0.001), no differences found > 0.05). In nationally representative children, we significant LD, even after adjusting demographic baseline. We also that differed race. Further investigation is needed causal relationships elucidate their potential mechanisms.

Язык: Английский

Процитировано

3
Exposure to Group B Streptococcus-induced chorioamnionitis alters the proteome of placental extracellular vesicles DOI

Seline Vancolen,

Mathilde Chevin, Bernard Robaire

и другие.

Placenta, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Prefrontal cortical microglial transcriptome relates to mouse offspring executive function deficits after perinatal opioid exposure in a sex-dependent manner DOI
Brittany Smith,

Brandon Brooks-Patton,

Justin L. Bollinger

и другие.

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
PlacentalIgf1Overexpression Sex-Specifically Impacts Mouse Placenta Structure, Altering Offspring Striatal Development and Behavior DOI Creative Commons
Annemarie Carver,

Faith M Fairbairn,

Robert J. Taylor

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

ABSTRACT Insulin-like growth factor 1 (IGF1) is produced primarily in the placenta utero and an essential hormone for neurodevelopment. Specifically, how placental IGF1 production persistently influences brain unclear. This study evaluated effects of Igf1 overexpression on embryonic postnatal development, particularly striatum, a region highly linked to neurodevelopmental disorders. Placental was overexpressed via placental-targeted CRISPR manipulation. altered structure function distinctly females males. Early differences trajectory striatal as adult showed persistent changes cell composition dependent behavior while males were less affected outcomes. Overall, these results demonstrate that expression alters development ways relevant These findings expand our understanding influence neurodevelopment will aid identifying preventive interventions. GRAPHICAL

Язык: Английский

Процитировано

0
Latent social communication cognition growth trajectories of term and preterm infants/toddlers based on caregiver report DOI
Renée Lajiness-O’Neill, Patricia A. Berglund, Seth Warschausky

и другие.

Pediatric Research, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Язык: Английский

Процитировано

0