Exosomes as drug delivery vehicles for Parkinson's disease therapy

Journal of Controlled Release, Год журнала: 2015, Номер 207, С. 18 - 30

Опубликована: Апрель 6, 2015

Язык: Английский

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Magnetic Resonance Spectroscopy to Assess NeuroInflammation and Neuropathic Pain

Journal of Neuroimmune Pharmacology, Год журнала: 2013, Номер 8(3), С. 576 - 593

Опубликована: Май 11, 2013

Язык: Английский

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Amyotrophic lateral sclerosis: A neurovascular disease

Brain Research, Год журнала: 2011, Номер 1398, С. 113 - 125

Опубликована: Май 20, 2011

Язык: Английский

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Fine-Tuning and the Stability of Recurrent Neural Networks

PLoS ONE, Год журнала: 2011, Номер 6(9), С. e22885 - e22885

Опубликована: Сен. 27, 2011

A central criticism of standard theoretical approaches to constructing stable, recurrent model networks is that the synaptic connection weights need be finely-tuned. This severe because proposed rules for learning these have been shown various limitations their biological plausibility. Hence it unlikely such are used continuously fine-tune network in vivo. We describe a rule able tune biologically plausible manner. demonstrate and test this context oculomotor integrator, showing only known neural signals needed weights. appropriately accounts wide variety experimental results, robust under several kinds perturbation. Furthermore, we show achieve stability as good or better than provided by linearly optimal often models integrator. Finally, discuss how can generalized attractor networks, those found head direction path integration systems, suggesting may stable systems.

Язык: Английский

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miR-141 and miR-200a, Revelation of New Possible Players in Modulation of Th17/Treg Differentiation and Pathogenesis of Multiple Sclerosis

PLoS ONE, Год журнала: 2015, Номер 10(5), С. e0124555 - e0124555

Опубликована: Май 4, 2015

Background One of the main issues in pathogenesis MS is Th17/Treg imbalance. There are growing interests nominating miRNAs involved Th17 cell differentiation, suggesting them as new therapeutic agents that may reduce progression different autoimmune diseases specially MS. Objectives We assessed transcript levels miR-141 and miR-200a patients, during relapsing remitting phases. also investigated possible role miR-141, inducing differentiation to cells. Materials Methods Forty RR-MS patient samples including (n=20) phases were chosen. Expression level measured by RT-q PCR compared healthy control group (n=10). In-silico analyses on targetome showed involvement both T helper pathways TGF-β, mTOR JAK/STAT. Results observed percentage RORγt+ CD4+ cells increase phase while FOXP3+ patients. Furthermore, show up-regulation patients groups. Interestingly, expression target genes miR-200a, which through in-silico methods, down-regulation Conclusions According our results, be key symptoms inhibiting Treg Our data suggest these probably inhibit negative regulators thus promoting its differentiation.

Язык: Английский

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Sympathoadrenergic modulation of hematopoiesis: a review of available evidence and of therapeutic perspectives

Frontiers in Cellular Neuroscience, Год журнала: 2015, Номер 9

Опубликована: Авг. 5, 2015

Innervation of the bone marrow (BM) has been described more than one century ago, however first in vivo evidence that sympathoadrenergic fibers have a role hematopoiesis dates back to less 25 years ago. Evidence since increased showing adrenergic nerves BM release noradrenaline and possibly also dopamine, which act on adrenoceptors dopaminergic receptors expressed hematopoietic cells affect cell survival, proliferation, migration engraftment ability. Remarkably, dysregulation is associated with disturbances myeloproliferative disease. Several agents are already clinical use for non-hematological indications usually favourable risk-benefit profile, therefore potential candidates non-conventional modulation hematopoiesis.

Язык: Английский

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AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, β-amyloidosis, and Learning Impairment of APP/PS1 Mice

Molecular Therapy, Год журнала: 2009, Номер 17(5), С. 803 - 809

Опубликована: Март 10, 2009

Accumulation of aggregated amyloid-β (Aβ) peptide was studied as an initial step for Alzheimer's disease (AD) pathogenesis. Following amyloid plaque formation, reactive microglia and astrocytes accumulate around plaques cause neuroinflammation. Here brain chemokines play a major role the glial accumulation. We have previously shown that transgenic overexpression chemokine CCL2 in results increased microglial accumulation diffuse deposition mouse model AD expressing Swedish precursor protein (APP) mutant. Here, we report adeno-associated virus (AAV) serotype 1 2 hybrid efficiently deliver 7ND gene, dominant-negative mutant, dose–response manner express >1,000-fold higher recombinant than basal levels after single administration. AAV1/2 principally infected neurons without neuroinflammation with sustained expression 6-months. expressed APP/presenilin-1 (APP/PS1) bigenic mice reduced astro/microgliosis, β-amyloidosis, including suppression both fibrillar oligomer Aβ accumulation, improved spatial learning. Our data support idea system is useful tool CNS gene delivery, may be therapeutic target amelioration AD-related

Язык: Английский

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Adult PTSD symptoms and substance use during Wave 1 of the COVID-19 pandemic

Addictive Behaviors Reports, Год журнала: 2021, Номер 13, С. 100341 - 100341

Опубликована: Март 7, 2021

This study examined associations between pandemic-related PTSD symptoms and substance use among adults, the role of gender socioeconomic status in these outcomes, supports that adults needed to address problems during Wave 1 COVID-19 pandemic Alberta, Canada.Data were collected from 933 community-based without a previous diagnosis June 2020. The Primary Care Screen was adapted assess symptoms. Participants asked if alcohol or cannabis had increased past month. Adjusted logistic regression models use.More women (19%) than men (13%) met criteria for high symptomology, while similar percentage (13.4% women, 13.2% men) reported significant increases pandemic. Adults 18-35 years; those who believed they would become infected with virus; low income, education, job loss more likely report High symptomology associated increase both (OR = 2.2) 2.3) adjusted models. Many (50% 40% help problems.Pandemic-related common COVID-19. These men. voiced need problems. Findings suggest interventions consider may be needed.

Язык: Английский

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CD 4+ T cells in the pathobiology of neurodegenerative disorders

Journal of Neuroimmunology, Год журнала: 2009, Номер 211(1-2), С. 3 - 15

Опубликована: Май 13, 2009

Язык: Английский

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Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders

Genomics Proteomics & Bioinformatics, Год журнала: 2016, Номер 14(3), С. 155 - 165

Опубликована: Май 28, 2016

The DNA damage response (DDR) is a complex biological system activated by different types of damage. Mutations in certain components the DDR machinery can lead to genomic instability disorders that culminate tissue degeneration, premature aging, and various cancers. Intriguingly, malfunctioning plays role etiology late onset brain degenerative such as Parkinson's, Alzheimer's, Huntington's diseases. For many years, were thought result from aberrant neural death. Here we discuss evidence supports our novel hypothesis diseases involve dysfunction glial cells (astrocytes, microglia, oligodendrocytes). Impairment functionality results pathological neuro-glial interactions that, turn, generate "hostile" environment impairs neuronal cells. These events systematic demise on scale appears be proportional severity neurological deficit.

Язык: Английский

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