Опубликована: Янв. 18, 2018
O uso de peptídeos na terapêutica apresenta inúmeras limitações, desde características físicoquímicas até perfil farmacocinético inadequado para absorção oral.Entretanto, novas estratégias sintéticas redução custos e aumento da estabilidade química metabólica peptídeos, associada a vias alternativas administração foram desenvolvidas permitiram o acesso
Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown
Опубликована: Март 29, 2025
As the clinical prevalence of antibiotic-resistant bacteria rises, effectiveness antibacterial drugs has been greatly reduced, hence, it is essential to create novel materials for combating bacterial infections. In recent years, antimicrobial peptides (AMPs) have demonstrated significant promise in addressing infections caused by bacteria, but as a natural product, they are limited terms activity and stability, cannot exert their full effect. The conjugation peptide-based biomaterials makes up this shortcoming, also improved, which lays foundation its application. This review aims introduce current progress AMPs-based treatment multidrug-resistant infections, covering topics from sources delivery combining biomaterial AMPs. addition, therapeutic advantages, including synergistic treatment, improved stability effectiveness, high biocompatibility, discussed. Finally, situation prospects AMP-based summarized.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1468 - 1468
Опубликована: Ноя. 18, 2024
This review explores the potential of peptide-based biomaterials to enhance biomedical applications through self-assembly, biological responsiveness, and selective targeting. Peptides are presented as versatile agents for antimicrobial activity drug delivery, with recent approaches incorporating peptides into self-assembling systems improve effectiveness reduce resistance. The also covers nanocarriers cancer highlighting their improved stability, targeted reduced side effects. focus this work is on bioactive properties peptides, particularly in infection control rather than structural design or material characteristics. Additionally, it examines role peptidomimetics broadening biomaterial enhancing resistance enzymatic degradation. Finally, discusses commercial prospects challenges translating peptide clinical applications.
Язык: Английский
Процитировано
0
Chimica et Natura Acta, Год журнала: 2016, Номер 4(3), С. 156 - 156
Опубликована: Дек. 12, 2016
A methyl ester of L-mandelic acid was found to be an effective resolving agent for resolution commercial DL-isoleucine. The based on Steglich esterification between L-mandelate and Boc-DL-isoleucine. two resolved isomers were easily separated by using a conventional flash-column chromatography, giving quantitatively good yields. Unfortunately, the ineffective resolve four stereoisomers Fmoc- isoleucine.
Язык: Английский
Процитировано
0
Опубликована: Янв. 18, 2018
O uso de peptídeos na terapêutica apresenta inúmeras limitações, desde características físicoquímicas até perfil farmacocinético inadequado para absorção oral.Entretanto, novas estratégias sintéticas redução custos e aumento da estabilidade química metabólica peptídeos, associada a vias alternativas administração foram desenvolvidas permitiram o acesso
Процитировано
0