Designs,
Год журнала:
2023,
Номер
7(1), С. 21 - 21
Опубликована: Фев. 1, 2023
Biotribology
is
applied
to
study
the
friction,
wear,
and
lubrication
of
biological
systems
or
natural
phenomena
under
relative
motion
in
human
body.
It
a
multidisciplinary
field
tribological
processes
impact
all
aspects
our
daily
life.
Tribological
may
occur
after
implantation
an
artificial
device
body
with
wide
variety
sliding
frictional
interfaces.
Blood
bio-lubricant
experiencing
laminar
flow
at
lower
screw
velocities
associated
drilling
implants
into
bone,
being
viscoelastic
fluid
viscous
characteristics.
The
viscosity
comes
from
blood
plasma,
while
elastic
properties
are
deformation
red
cells.
In
this
study,
parameters
according
material
obtained
by
Finite
Element
Analysis
given.
influence
on
resulting
friction
between
surfaces
demonstrated
correlated
mechanical
consequences,
identifying
innovative
approach
obtaining
new
lubricant
parameter
for
bone
analysis.
(HN)
found
within
limitations
conditions
used
10.7
×
10−7
both
cortical
(D1)
spongy
(D4).
A
thermal-structural
analysis
densities
soft
(D4)
hard
shows
differences
only
equivalent
stress
values
due
respective
Young
moduli.
occurrences
as
bone-screw
perforations
poorly
investigated
literature
its
effects
fundamental
osseointegration.
This
work
aims
elucidate
relevance
screwing
speeds.
American Journal of Hematology,
Год журнала:
2023,
Номер
98(7), С. 1017 - 1028
Опубликована: Март 27, 2023
Despite
a
wealth
of
exploratory
plasma
metabolomics
studies
in
sickle
cell
disease
(SCD),
no
study
to
date
has
evaluate
large
and
well
phenotyped
cohort
compare
the
primary
erythrocyte
metabolome
hemoglobin
SS,
SC
transfused
AA
red
blood
cells
(RBCs)
vivo.
The
current
evaluates
RBC
587
subjects
with
(SCD)
from
WALK-PHaSST
clinical
cohort.
set
includes
SCD
patients,
variable
levels
HbA
related
transfusion
events.
Here
we
explore
modulating
effects
genotype,
age,
sex,
severity
hemolysis,
therapy
on
metabolism.
Results
show
that
RBCs
patients
Hb
SS
genotypes-compared
recent
events
or
RBCs-are
characterized
by
significant
alterations
acylcarnitines,
pyruvate,
sphingosine
1-phosphate,
creatinine,
kynurenine
urate
Surprisingly,
metabolism
is
dramatically
different
all
glycolytic
intermediates
significantly
elevated
RBCs,
exception
pyruvate.
This
result
suggests
metabolic
blockade
at
ATP-generating
phosphoenolpyruvate
pyruvate
step
glycolysis,
which
catalyzed
redox-sensitive
kinase.
Metabolomics,
hematological
data
were
collated
novel
online
portal.
In
conclusion,
identified
signatures
HbS
correlate
degree
steady
state
hemolytic
anemia,
cardiovascular
renal
dysfunction
mortality.
Materials Today Bio,
Год журнала:
2023,
Номер
20, С. 100687 - 100687
Опубликована: Июнь 1, 2023
Chronic
wounds
have
always
been
considered
as
"gordian
knots"
in
medicine,
which
hypoxia
plays
a
key
role
blocking
healing.
To
address
this
challenge,
although
tissue
reoxygenation
therapy
based
on
hyperbaric
oxygen
(HBOT)
has
performed
clinically
for
several
years,
the
bench
to
bedside
still
urges
evolution
of
oxygen-loading
and
-releasing
strategies
with
explicit
benefits
consistent
outcome.
The
combination
various
carriers
biomaterials
gained
momentum
an
emerging
therapeutic
strategy
field,
exhibiting
considerable
application
potential.
This
review
gives
overview
essential
relationship
between
delayed
wound
Further,
detailed
characteristics,
preparation
methods
applications
oxygen-releasing
(ORBMs)
will
be
elaborated,
including
hemoglobin,
perfluorocarbon,
peroxide,
oxygen-generating
microorganisms,
those
are
applied
load,
release
or
generate
vast
relieve
hypoxemia
bring
subsequent
cascade
effect.
pioneering
papers
regarding
ORBMs
practice
presented
trends
toward
hybrid
more
precise
manipulation
summarized.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 16, 2024
Abstract
Oxygen
is
necessary
for
life
and
plays
a
key
pivotal
in
maintaining
normal
physiological
functions
treat
of
diseases.
Hemoglobin-based
oxygen
carriers
(HBOCs)
have
been
studied
developed
as
replacement
red
blood
cells
(RBCs)
transport
due
to
their
similar
oxygen-carrying
capacities.
However,
applications
HBOCs
are
hindered
by
vasoactivity,
oxidative
toxicity,
relatively
short
circulatory
half-life.
With
advancements
nanotechnology,
Hb
encapsulation,
absorption,
bioconjugation,
entrapment,
attachment
nanomaterials
used
prepare
nanomaterial-related
address
these
challenges
pend
application
several
biomedical
therapeutic
contexts.
This
review
focuses
on
the
progress
this
class
fields
hemorrhagic
shock,
ischemic
stroke,
cancer,
wound
healing,
speculates
future
research
directions.
The
expected
lead
significant
breakthroughs
substitutes,
enabling
widespread
use
treatment
clinical
Graphical
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
156, С. 113982 - 113982
Опубликована: Ноя. 7, 2022
High
altitude
pulmonary
edema
(HAPE)
is
a
potentially
fatal
condition
induced
by
exposure
to
high-altitude
environment.
Eleutheroside
B
naturally
active
polyphenolic
substance
that
has
previously
demonstrated
anti-inflammatory,
antioxidant
and
antidepressant
properties.
However,
the
effects
of
eleutheroside
on
HPAE
are
unknown.
Here,
(50
mg/kg
100
mg/kg)
was
applied
HAPE
rats.
alleviated
lung
decreased
levels
tumor
necrosis
factor-α,
interleukin-1β,
vascular
endothelial
growth
factor,
total
proteins
in
bronchoalveolar
lavage
fluid.
reversed
acid-base
disturbances
HAPE.
In
addition,
oxidative
stress.
pretreatment
facilitated
translocation
nuclear
factor
E2-related
2
(Nrf2)
into
nucleus,
contributing
inhibition
ferroptosis
necroptosis.
ML385
confirmed
role
Nrf2
Collectively,
beneficial
against
were
associated
with
necroptosis
through
Nrf2-antioxidant
response
signaling.
ACS Sensors,
Год журнала:
2024,
Номер
9(9), С. 4364 - 4379
Опубликована: Авг. 23, 2024
Breast
cancer
is
a
major
challenge
in
the
field
of
oncology,
with
around
2.3
million
cases
and
670,000
deaths
globally
based
on
GLOBOCAN
2022
data.
Despite
having
advanced
technologies,
breast
remains
type
among
women.
This
review
highlights
various
collagen
signatures
role
different
types
tumor
development,
progression,
metastasis,
along
use
photoacoustic
spectroscopy
to
offer
insights
into
future
diagnostic
applications
without
need
for
surgery
or
other
invasive
techniques.
Through
mapping
microenvironment
spotlighting
key
components
their
absorption
wavelengths,
we
emphasize
extensive
preclinical
clinical
investigations.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 30, 2022
Antineutrophil
cytoplasmic
antibody
(ANCA)-associated
vasculitis
(AAV)
is
a
multisystem
autoimmune
disease
with
small-vessel
involvement.
In
AAV,
microscopic
polyangiitis
(MPA)
and
granulomatosis
(GPA)
are
major
clinicopathologic
variants.
addition,
myeloperoxidase
(MPO)
proteinase
3
(PR3)
target
antigens.
The
objective
of
the
study
was
to
explore
predictive
factors
for
long-term
survival
in
AAV
patients.
A
multicenter
retrospective
carried
out
on
407
patients
between
2005
2020.
Clinical
parameters
were
obtained
from
laboratory
tests
including
ANCA
types,
antinuclear
(ANA),
extractable
nuclear
antigen
(ENA),
anti-streptolysin
O
(ASO),
glomerular
filtration
rate
(GFR),
examinations
blood
routine,
liver
function,
renal
immunity,
etc.
data
clinical
collected
electronic
medical
records
(EMRs),
patient
acquired
through
regular
follow-up.
association
overall
(OS)
along
3-year
5-year
rates
analyzed,
nomogram
as
model
established
according
analysis
results.
present
study,
336
(82.6%)
46
(11.3%)
diagnosed
MPA
GPA,
respectively.
mean
median
OS
all
2,285
2,290
days,
1-year,
3-year,
5-year,
10-year
cumulative
84.2%,
76.3%,
57.2%,
32.4%,
Univariate
multivariate
analyses
indicated
that
independent
prognostic
included
age,
pathological
categories
(MPA,
other
types),
serum
types
(negative
or
positive
MPO
and/or
PR3),
ANA,
ASO,
GFR,
lymphocyte,
neutrophil-to-lymphocyte
ratio
(NLR),
C-reactive
protein
(CRP),
these
except
ASO
used
construct
nomogram.
had
C-index
0.721
(95%
CI
0.676-0.766).
calibration
curves
showed
predicted
values
generally
consistent
practical
observed
values,
decision
curve
(DCA)
further
demonstrated
practicability
accuracy
model.
Laboratory
at
diagnosis
have
great
significance
prediction
