Photoclick and Release for Spatiotemporally Localized Theranostics of Single Cells via In Situ Generation of 1,3‐Diaryl‐1H‐benzo[f]indazole‐4,9‐dione DOI Open Access
Baolin Li,

Sitong Li,

Cefei Zhang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Bioorthogonal click‐release chemistry is a cutting‐edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it challenging to achieve the precise regulation or therapy of individual cells via strategies driven by proximity thermodynamics. Herein, we propose novel photoclick‐release approach based on photo‐induced cycloaddition between 4,4′‐bis( N ‐arylsydnone) C ‐bithienyl‐diarylsydnone 2‐arylamino‐naphthoquinone irradiation with 405 485 nm light. It constructs 1,3‐diaryl‐1 H ‐benzo[ f ]indazole‐4,9‐dione (BIZON) as pharmacophore while releases an arylamine fluorescence turn‐on probing. Both photoclick reagents were tailored connecting triphenyl phosphonium delivery motif enrichment mitochondria live cells. This enables intracellular release under control We then discovered that situ photo‐generated BIZON capable photosensitizing upon 520 light produce singlet oxygen inside aerobic conditions. Therefore, realized wash‐free tracking subsequent anti‐cancer efficacy at single‐cell resolution using global illumination, which provides foundation wavelength‐gated theranostics.

Язык: Английский

A multifunctional ROS cascade nanoplatform enables common prosperity of O2 and H2O2 for magnetic targeting and fluorescence imaging-guided photodynamic/chemodynamic therapy DOI

Linshan Jia,

Zimeng Zhou,

Xiaotong Li

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер 506, С. 160178 - 160178

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Recent advances in nanomaterials for integrated phototherapy and immunotherapy DOI Creative Commons
Zhuqing Sun, Nannan Wang, Yelin Wu

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216608 - 216608

Опубликована: Март 27, 2025

Язык: Английский

Процитировано

1
A Microneedle Patch Delivers Mitochondria‐ and Lysosomes‐ Dual Targeting Prodrug‐Like Photosensitizers with Regulated Photoactivity for Precise Photodynamic Therapy DOI Open Access
Zheng Liu,

Zhimin Tang,

Ying Yin

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Antitumor photodynamic therapy (PDT) faces huge challenges as selectivity and phototoxic damage, requiring delivery photosensitizers (PSs) to specifically accumulate in tumors even organelle, avoid the damage during delivery. Herein, a microneedle patch (AIE-mito-TPP@MN) containing mitochondria- lysosomes- dual targeting prodrug-like PSs (AIE-mito-TPP/AlPcSNa4) that is self-assembled by mitochondria-targeted aggregation-induced-emission molecule (AIE-mito-TPP) lysosome-targeted aluminum phthalocyanine tetrasulfonate (AlPcSNa4), developed achieve cancer-cell-organelle-specific for precise PDT with high low damage. AIE-mito-TPP/AlPcSNa4 displays activity via regulated photoactivity reduce caused "always on" PSs. Meanwhile, AIE-mito-TPP/AlPcSNa4@MN can insert into epidermis rapid tumor lesion, enhance selective accumulation cells. The higher lysosomal acidity cells facilitates disassembly promotes targeting. Under light irradiation, impairs mitochondrial function induce deeper apoptosis at dose (≈6 µg), presenting greater therapeutic efficacy than AIE-mito-TPP@MN, AlPcSNa4@MN, or intravenous injection. Moreover, presents good biocompatibility lower normal cells, well of Therefore, organelle-targeting possesses great potential selectivity.

Язык: Английский

Процитировано

0
Cascade-recharged macrophage-biomimetic ruthenium-based nanobattery for enhanced photodynamic-induced immunotherapy DOI Creative Commons

Guoyu Xia,

Zhongxiong Fan, Qi Wang

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 4, 2025

Photodynamic-induced immunotherapy (PDI) is often hampered by low reactive oxygen species (ROS) yield, intra-tumor hypoxia, high glutathione (GSH) concentration, and immunosuppressive microenvironment. In view of this, a ruthenium (Ru)-based nanobattery (termed as IRD) with cascade-charged (O2), ROS, photodynamic-induced coordination-driven self-assembly transition-metal Ru, photosensitizer indocyanine green (ICG), organic ligand dithiobispropionic acid (DTPA). Then, IRD camouflaged macrophage membranes to obtain IRD@M) targeting immune evasion capabilities. Upon intravenous administration, IRD@M core-shell structure, nano diameter, good stability can specifically hoard in tumor location internalize into cells. disassembly triggered GSH, the released Ru³⁺ not only catalyzes conversion endogenous hydrogen peroxide (H₂O₂) O₂ alleviate hypoxia reduce expression hypoxia-inducible factor-1α (HIF-1α), but also generates hydroxyl radicals (·OH) elevate intracellular ROS levels. This process significantly enhances photodynamic therapy (PDT) efficacy ICG. Meanwhile, DTPA downregulate overexpressed GSH elimination deriving from PDT exchange reaction thiol-disulfide bond. It found that alleviating hypoxic microenvironment synergistically efficacy, which turn cascades recharge subsequent response, improving activating systemic tumor-specific immunity. Notably, vitro vivo experimental results jointly confirm such cascade-recharged macrophage-biomimetic Ru-based achieve an obvious while minimized side effect. Taken together, this work highlights promising strategy for simple, flexible, effective immunogenic cell death (ICD) agents within PDI.

Язык: Английский

Процитировано

0
Gold Nanocage/DNA Nanoplatforms with Multivalent Aptamers Based on Rolling Circle Amplification for Tumor-Targeted Drug Controlled Release and Synergistic Therapy DOI
Xiaoqun Gong, Guodong Zhang, Jingjing Zhuang

и другие.

ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Язык: Английский

Процитировано

0
NIR II‐Guided Photoactivatable Silencing Polyplex Boosts Cancer Immunotherapy DOI Creative Commons

Yuquan Zhang,

Jie Wang, Tian Zhang

и другие.

Exploration, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

ABSTRACT Photodynamic therapy (PDT) triggers immunogenic cell death (ICD) within the tumor microenvironment, consequently enhancing immunotherapy. However, maximum absorption wavelengths of first and second‐generation PDT photosensitizers limit penetration depth therapeutics, resulting in insufficient anti‐tumor outcomes. This study reports a custom‐designed polymer, PTSQ, which exhibits significant near‐infrared region (NIR) window fluorescence emission spectra NIR II range, demonstrating excellent efficiency. Additionally, PTSQ self‐assembles into nanomicelles, exhibiting outstanding siRNA delivery. To further enhance immunotherapy, we introduce an immune checkpoint blockade strategy prepared PTSQ/siPD‐L1 complexes. We present novel approach to treatment by combining light‐activated ICD siPD‐L1 therapy. At cellular level, complexes exhibit potent induction while concurrently suppressing PD‐L1 gene expression. In vivo, these significantly impede growth CT26, 4T1, patient‐derived xenograft (PDX) tumors. effect is achieved promoting situ ICD, reverses environment activates cells tumors spleens, including T cells, dendritic (DCs), macrophages. Overall, this offers insights for development II‐guided cancer immunotherapy underscores efficacy conjunction with treatment.

Язык: Английский

Процитировано

0
Optimizing mitochondrial-targeting groups of positively-charged BODIPY nanoparticles for enhanced photodynamic therapy DOI
Huixuan Qi,

Ruobing Qu,

Jiaping Shen

и другие.

Materials Chemistry Frontiers, Год журнала: 2024, Номер 8(23), С. 3898 - 3905

Опубликована: Янв. 1, 2024

1-Methylimidazole-modified BODIPY nanoprobes were developed for highly efficient mitochondrial targeting and enhanced photo dynamic therapy.

Язык: Английский

Процитировано

1
Photoclick and Release for Spatiotemporally Localized Theranostics of Single Cells via In Situ Generation of 1,3‐Diaryl‐1H‐benzo[f]indazole‐4,9‐dione DOI
Baolin Li,

Sitong Li,

Cefei Zhang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Bioorthogonal click‐release chemistry is a cutting‐edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it challenging to achieve the precise regulation or therapy of individual cells via strategies driven by proximity thermodynamics. Herein, we propose novel photoclick‐release approach based on photo‐induced cycloaddition between 4,4′‐bis( N ‐arylsydnone) C ‐bithienyl‐diarylsydnone 2‐arylamino‐naphthoquinone irradiation with 405 485 nm light. It constructs 1,3‐diaryl‐1 H ‐benzo[ f ]indazole‐4,9‐dione (BIZON) as pharmacophore while releases an arylamine fluorescence turn‐on probing. Both photoclick reagents were tailored connecting triphenyl phosphonium delivery motif enrichment mitochondria live cells. This enables intracellular release under control We then discovered that situ photo‐generated BIZON capable photosensitizing upon 520 light produce singlet oxygen inside aerobic conditions. Therefore, realized wash‐free tracking subsequent anti‐cancer efficacy at single‐cell resolution using global illumination, which provides foundation wavelength‐gated theranostics.

Язык: Английский

Процитировано

0
Photoclick and Release for Spatiotemporally Localized Theranostics of Single Cells via In Situ Generation of 1,3‐Diaryl‐1H‐benzo[f]indazole‐4,9‐dione DOI Open Access
Baolin Li,

Sitong Li,

Cefei Zhang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Bioorthogonal click‐release chemistry is a cutting‐edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it challenging to achieve the precise regulation or therapy of individual cells via strategies driven by proximity thermodynamics. Herein, we propose novel photoclick‐release approach based on photo‐induced cycloaddition between 4,4′‐bis( N ‐arylsydnone) C ‐bithienyl‐diarylsydnone 2‐arylamino‐naphthoquinone irradiation with 405 485 nm light. It constructs 1,3‐diaryl‐1 H ‐benzo[ f ]indazole‐4,9‐dione (BIZON) as pharmacophore while releases an arylamine fluorescence turn‐on probing. Both photoclick reagents were tailored connecting triphenyl phosphonium delivery motif enrichment mitochondria live cells. This enables intracellular release under control We then discovered that situ photo‐generated BIZON capable photosensitizing upon 520 light produce singlet oxygen inside aerobic conditions. Therefore, realized wash‐free tracking subsequent anti‐cancer efficacy at single‐cell resolution using global illumination, which provides foundation wavelength‐gated theranostics.

Язык: Английский

Процитировано

0