A Review on Apple Pomace Bioactives for Natural Functional Food and Cosmetic Products with Therapeutic Health-Promoting Properties
Maria Vandorou,
Christos Plakidis,
Ilektra Maria Tsompanidou
и другие.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10856 - 10856
Опубликована: Окт. 9, 2024
Apples
are
consumed
lavishly
worldwide,
while
demand
is
increasing
for
the
management
of
huge
apple-waste
amounts
that
lead
to
significant
disposal
costs
and
ecological
issues.
Additionally,
apples
represent
fruits
with
several
bioactive
constituents,
which
key
factors
in
a
healthy,
balanced
diet.
In
present
study,
an
extensive
review
presented
regarding
compounds
apple
processing
by-product,
namely
pomace,
mentioning
their
significance
as
viable
ingredients/substances
foods
cosmetics
aiming
at
chronic
disease
prevention
health
promotion.
Apple
pomace
contains
such
polar
lipids,
phenolics,
vitamins
dietary
fibers,
potential
antioxidant,
anti-inflammatory,
anti-thrombotic,
anti-aging
skin-protecting
properties,
thus,
they
may
contribute
minimizing
risk
various
conditions.
mechanisms
action
functional
bioactives
from
exert
benefits
will
be
examined,
synergistic
effects
also
investigated.
Moreover,
we
methods
techniques
needed
utilization
appropriate
form,
powder,
extracts,
essential
oil
so
on,
applications
food
cosmeceutical
industry
sectors,
summarize
represents
ideal
alternative
synthetic
compounds.
Язык: Английский
Re-Assessing the Role of Platelet Activating Factor and Its Inflammatory Signaling and Inhibitors in Cancer and Anti-Cancer Strategies
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(10)
Опубликована: Сен. 26, 2024
Since
2000s,
we
have
outlined
the
multifaceted
role
of
inflammation
in
several
aspects
cancer,
via
specific
inflammatory
mediators,
including
platelet
activating
factor
(PAF)
and
PAF-receptor
(PAFR)
related
signaling,
which
affect
important
junctions
cellular
interactions
that
are
associated
with
tumor-related
manifestations.
It
is
now
well
established
disease-related
unresolved
chronic
responses
can
promote
carcinogenesis.
At
same
time,
tumors
themselves
able
to
their
progression
metastasis,
by
triggering
an
inflammation-related
vicious
cycle,
PAF
its
signaling
play
crucial
role(s),
usually
conclude
tumor
growth
angiogenesis.
In
parallel,
new
evidence
suggests
also
interact
cancer
treatments
inducing
antitumor
immune
response
or,
conversely,
promoting
recurrence.
Within
this
review
article,
current
knowledge
future
perspectives
implication
all
these
thoroughly
re-assessed.
The
potential
beneficial
PAF-inhibitors
natural
or
synthetic
modulators
PAF-metabolism
against
tumors,
metastasis
evaluated.
Emphasis
given
molecules
dual
anti-PAF
anti-cancer
activities
(Bio-DAPAC-tives),
proven
potency
through
clinical
trials,
as
on
metal-based
anti-inflammatory
mediators
constitute
a
class
potent
inhibitors.
way
compounds
may
anti-tumor
effects
modulate
actions
discussed.
Limitations
targeting
PAF,
metabolism
receptor,
PAF-related
part(s)
strategies
involve
response(s)
for
improved
outcome,
Язык: Английский