In Vitro Antioxidant, Antithrombotic and Anti-Inflammatory Properties of the Amphiphilic Bioactives from Greek Organic Starking Apple Juice and Its By-Products (Apple Pomace)
Maria Vandorou,
Christos Plakidis,
Ilektra Maria Tsompanidou
и другие.
Applied Sciences,
Год журнала:
2025,
Номер
15(5), С. 2807 - 2807
Опубликована: Март 5, 2025
The
anti-inflammatory,
antithrombotic
and
antioxidant
effects
of
extracts
from
both
apple
juice
by-products
(apple
pomace)
organic
cultured
Greek
Starking
apples
were
evaluated
in
vitro.
All
separated
their
total
amphiphilic
compounds
(TACs)
lipophilic
(TLCs)
assessed
for
phenolic
content
(TPC),
carotenoid
(TCC)
activities
(by
the
DPPH,
ABTS
FRAP
assays),
as
well
anti-inflammatory
potency
against
thrombo-inflammatory
mediator,
platelet
activating
factor
(PAF)
a
standard
platelet-agonist
(ADP)
human
platelets.
rich-in-TAC
showed
much
higher
phenolics
carotenoids
than
TLC
extracts,
which
was
also
reflected
by
stronger
capacities
observed
TAC.
ATR-FTIR
spectroscopy
revealed
presence
not
only
but
polar
lipids
(PLs)
TAC,
structural
analysis
with
LC–MS
further
fatty
acid
composition
favorable
unsaturated
acids
(UFAs)
versus
saturated
ones
(SFAs).
such
bioactive
PLs
that
are
rich
UFA
within
TAC
pomace
provide
an
explanation
potent
properties
these
mainly
inflammatory
pathway
PAF
aggregation
induced
ADP.
Overall,
results
support
antioxidant,
potential
especially
by-products,
can
be
utilized
sustainable
ingredients
several
functional
products
circular
economy
design.
Язык: Английский
Marine Fungi Bioactives with Anti-Inflammatory, Antithrombotic and Antioxidant Health-Promoting Properties Against Inflammation-Related Chronic Diseases
Maria-Aliki Papikinou,
Konstantinos Pavlidis,
Paschalis Cholidis
и другие.
Marine Drugs,
Год журнала:
2024,
Номер
22(11), С. 520 - 520
Опубликована: Ноя. 18, 2024
Fungi
play
a
fundamental
role
in
the
marine
environment,
being
promising
producers
of
bioactive
molecules
pharmacological
and
industrial
fields,
which
have
demonstrated
potential
health
benefits
against
cardiovascular
other
chronic
diseases.
This
review
pertains
to
analysis
lipid
compositions
across
various
species
fungi
their
constantly
discovered
substances,
as
well
anti-inflammatory,
antioxidant,
antithrombotic
effects.
The
health-promoting
aspects
these
microorganisms
will
be
explored,
through
investigation
several
mechanisms
action
interference
bioactives
biochemical
pathways.
Despite
exceptional
results
this
field,
remains
largely
unexplored
due
limited
number
specialists
microbiology
mycology,
relatively
recent
science
with
significant
contributions
biodiversity
biotechnology.
Язык: Английский
Copper- and Iron-Based Nanoflowers in Cancer Theranostics
Applied Sciences,
Год журнала:
2024,
Номер
14(23), С. 11294 - 11294
Опубликована: Дек. 4, 2024
In
recent
years,
nanoscience
and
nanotechnology
have
gained
prominence
within
materials
science,
offering
new
opportunities
for
cancer
diagnosis
treatment.
Advances
in
allowed
the
manipulation
size
control
of
nanomaterials,
leading
to
development
a
wide
range
materials.
The
use
nanomaterials
as
chemical
biology
tools
theranostics
has
been
widely
investigated,
owing
their
enhanced
stability,
biocompatibility,
improved
cell
permeability.
These
properties
enable
precise
targeting
while
addressing
limitations
conventional
treatments.
Nanoflowers,
specific
class
recently
attracted
significant
interest
due
promising
several
biomedical
applications.
However,
despite
growing
attention
toward
nanoflowers,
detailed
reviews
on
subject
limited.
This
work
focuses
two
primary
types
hybrid
nanoflowers:
iron-
copper-based
ones.
Within
this
article
an
overview
applications
are
thoroughly
reviewed,
synthesis
processes
controlling
morphology
size,
underlying
functions,
characteristics
uses
also
extensively
explored,
aiming
provide
guide
future
developments
field.
Язык: Английский
Anti-Inflammatory, Antithrombotic, and Antioxidant Properties of Amphiphilic Lipid Bioactives from Shrimp
Pharmaceuticals,
Год журнала:
2024,
Номер
18(1), С. 25 - 25
Опубликована: Дек. 28, 2024
Background/Objectives:
Marine
organisms,
including
shrimps,
have
gained
research
interest
due
to
containing
an
abundance
of
bioactive
lipid
molecules.This
study
evaluated
the
composition
and
in
vitro
biological
activities
amphiphilic
compounds
from
four
different
wild
shrimp
species:
Litopenaeus
vannamei,
Penaeus
kerathurus,
Aristaeomorpha
foliacea,
Parapenaeus
longirostris.
Methods:
Total
(TL)
extracts
were
obtained
separated
into
total
(TAC)
lipophilic
(TLC)
compounds.
Phenolic
(TPC)
carotenoid
(TCC)
contents,
antioxidant
(DPPH,
ABTS,
FRAP
assays),
effects
on
platelet-activating
factor
(PAF)
ADP-induced
platelet
activation
evaluated.
Structural
analyses
performed
using
ATR-FTIR
spectroscopy,
while
LC-MS
was
used
elucidate
fatty
acid
overall
structure
polar
lipids
(PLs)
present
TAC
extracts.
Results:
extracts,
rich
phenolics,
carotenoids,
PL,
unsaturated
acids
(UFAs),
exhibited
stronger
anti-inflammatory
antithrombotic
compared
with
TLC
which
showed
potent
capacity.
Significant
amounts
UFAs,
such
as
monounsaturated
(MUFA)
oleic
(C18:1n9)
omega-3
(n3)
polyunsaturated
(PUFAs)
like
eicosapentaenoic
(EPA;
C20:5n3)
docosahexaenoic
(DHA;
C22:6n3),
detected
PLs
favorable
values
for
their
n6/n3
PUFA
ratio.
Shrimp
bioactives
provide
against
PAF
pathway
ADP
eicosanoid
pathways.
Conclusions:
The
findings
support
further
use
anti-inflammatory,
anti-thrombotic,
ingredients
produce
new
bio-functional
health-promoting
products,
context
sustainable
development
circular
economy.
Язык: Английский