Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus
Cells,
Год журнала:
2025,
Номер
14(2), С. 143 - 143
Опубликована: Янв. 19, 2025
Brain
plasticity
is
at
the
basis
of
many
cognitive
functions,
including
learning
and
memory.
It
includes
several
mechanisms
synaptic
extrasynaptic
changes,
neurogenesis,
formation
elimination
synapses.
The
transmission
involves
expression
immediate
early
genes
(IEGs)
that
regulate
neuronal
activity,
thereby
supporting
In
addition,
IEGs
are
involved
in
regulation
brain
cells’
metabolism,
proliferation,
survival,
establishment
multicellular
ensembles,
and,
presumably,
cell
competition
tissue.
this
review,
we
analyze
current
understanding
role
(c-Fos,
c-Myc,
Arg3.1/Arc)
controlling
physiological
pathological
conditions,
aging
neurodegeneration.
This
work
might
inspire
new
gene
therapy
strategies
targeting
to
plasticity,
potentially
prevent
or
mitigate
neurodegenerative
diseases.
Язык: Английский
Neuronal enhancers fine-tune adaptive circuit plasticity
Neuron,
Год журнала:
2024,
Номер
112(18), С. 3043 - 3057
Опубликована: Авг. 28, 2024
Язык: Английский
Dynamic memory enqrams: Unveiling the celular mechanisms of memory encoding, consolidation, generalizaton, and updating in the brain
Brain medicine :,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Май 20, 2025
One
of
the
fundamental
questions
neuroscience
is
how
brain
can
store,
generalize,
and
update
memories.
Memories
are
believed
to
be
stored
through
biophysical
molecular
changes
in
neuronal
ensembles
called
engrams,
which
distributed
across
different
regions.
The
dynamic
that
occur
engram
cells
during
encoding,
consolidation,
generalization,
updating
memory
still
not
fully
understood.
However,
recent
advancements
techniques
for
labeling
manipulating
neural
activity
have
allowed
investigation
engrams
processes.
Understanding
dynamics
may
inform
interventions
posttraumatic
stress
disorder
disorders.
In
this
review,
we
summarize
progress
updating,
shedding
new
light
on
mechanisms
underlying
formation
maturation.
Язык: Английский
Spatially resolved transcriptomic signatures of hippocampal subregions and Arc-expressing ensembles in active place avoidance memory
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Окт. 31, 2024
The
rodent
hippocampus
is
a
spatially
organized
neuronal
network
that
supports
the
formation
of
spatial
and
episodic
memories.
We
conducted
bulk
RNA
sequencing
transcriptomics
experiments
to
measure
gene
expression
changes
in
dorsal
following
recall
active
place
avoidance
(APA)
memory.
Through
sequencing,
we
examined
memory
across
functionally
distinct
subregions
hippocampus.
found
induced
differentially
expressed
genes
(DEGs)
CA1
CA3
hippocampal
were
enriched
with
involved
synaptic
transmission
plasticity,
while
DEGs
dentate
gyrus
(DG)
energy
balance
ribosomal
function.
transcriptomics,
an
array
spots
encompassing
putative
memory-associated
ensembles
marked
by
IEGs
Язык: Английский