Malaysian Journal of Medicine and Health Sciences,
Год журнала:
2023,
Номер
19(s18), С. 52 - 59
Опубликована: Дек. 22, 2023
Introduction:
Obesity
is
a
major
concern
on
global
scale,
particularly
in
Malaysia.
It
causes
physiological
imbalance
the
regulation
and
normal
functioning
of
adipose
tissue,
leading
to
other
medical
issues
such
as
hyperglycaemia,
dyslipidaemia,
inflammation.
These
conditions
trigger
production
oxidative
stress,
which
worsened
by
decrease
antioxidant
defence
systems
obese
patients.
Methods:
This
study
was
conducted
evaluate
body
mass
index
(BMI),
waist-to-hip
ratio
(WHR),
level
subcutaneous
fat
whole
body,
trunk,
leg,
arm
visceral
subjects,
their
relationship
with
DNA
damage
parameters
among
students
Faculty
Pharmacy
(n=89)
Universiti
Teknologi
MARA
(UiTM).
assessed
using
Comet
Assay.
Results:
No
significant
differences
(p>0.05)
tail
length,
moment,
olive
percentage
were
observed
between
groups,
although
greater
value
(mean
±
SD)
seen
overweight
group.
There
also
no
correlation
anthropometric
measurements
(p>0.05).
In
summary,
it
can
be
concluded
that
there
difference
levels
overweight/obese
group
BMI
Conclusion:
Further
should
understand
mechanism/s
contributed
this
condition.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7276 - 7276
Опубликована: Июль 2, 2024
Obesity
is
a
worldwide
increasing
concern.
Although
in
adults
this
easily
estimated
with
the
body
mass
index,
children,
who
are
constantly
growing
and
whose
bodies
changing,
reference
points
to
assess
weight
status
age
gender,
need
corroboration
complementary
data,
making
their
quantification
highly
difficult.
The
present
review
explores
interaction
spectrum
of
oxidative
stress,
selenium
status,
obesity
children
adolescents.
Any
factor
related
stress
that
triggers
and,
conversely,
induces
part
vicious
circle,
complex
chain
mechanisms
derive
from
each
other
reinforce
serious
health
consequences.
Selenium
its
compounds
exhibit
key
antioxidant
activity
also
have
significant
role
nutritional
evaluation
obese
children.
balance
intake,
retention,
metabolism
emerges
as
vital
aspect
health,
reflecting
interactions
between
diet,
obesity.
Understanding
whether
contributor
or
consequence
could
inform
interventions
public
strategies
aimed
at
preventing
managing
an
early
age.
Asian Pacific Journal of Cancer Prevention,
Год журнала:
2018,
Номер
19(12), С. 3511 - 3515
Опубликована: Дек. 1, 2018
Background:
Breast
cancer
is
caused
by
breast
tissue
malignant
cells
and
it
has
become
one
of
the
main
medical
concerns
with
a
socio-economic
significance
especially
for
women.
Among
multiple
factors
involved
in
initiation,
progression,
invasion
cancer,
oxidative
stress
plays
an
important
role.
Antioxidant
status,
lipid
peroxidation,
newly
diagnosed
patients
were
determined
to
find
defined
pattern
these
patients.
Methods:
The
malondialdehyde
(MDA)
levels
(as
indicator
peroxidation),
glutathione
peroxidase
(GPX),
superoxide
dismutase
(SOD)
activities
(n=38)
controls
assessed
using
blood
samples.
Results:
MDA
level
SOD
activity
significantly
higher
compared
healthy
subjects
group
(p<0.05).
Compared
group,
GPX
decreased
Conclusions:
High
peroxidation
risk
factor
increased
anion
may
be
reason
induction
activity.
Nevertheless,
development
progression
cancer.
Further
studies
on
can
lead
more
helpful
approach
management
Mutagenesis,
Год журнала:
2017,
Номер
33(1), С. 61 - 67
Опубликована: Ноя. 23, 2017
Obesity
is
associated
with
several
detrimental
health
consequences,
among
them
an
increased
risk
for
development
of
cancer,
and
overall
elevated
mortality.
Multiple
factors
like
hyperinsulinemia,
chronic
microinflammation
oxidative
stress
may
be
involved.
The
comet
assay
has
been
proven
to
very
sensitive
detection
DNA
damage
used
explore
the
relationship
between
overweight/obesity
damage,
but
results
are
controversial.
Very
few
investigations
have
performed
correlate
weight
loss
obese
individuals
possible
reduction
these
studies
not
provided
clear
results.
As
currently,
only
surgical
interventions
(metabolic/bariatric
surgery)
enable
substantial
sustained
in
vast
majority
morbidly
patients,
we
analyzed
whole
blood
samples
56
subsequent
patients
prior,
6
12
months
after
bariatric
surgery.
No
was
observed
analysis
despite
efficient
loss,
a
significant
Concurrently,
ferric-reducing
antioxidant
power
showed
months.
level
oxidised
glutathione
lipid
peroxidation
products
were
at
normalised
conclusion,
help
diminish
existing
besides
improving
many
other
aspects
patients.
Endocrine Connections,
Год журнала:
2018,
Номер
7(9), С. 990 - 997
Опубликована: Сен. 1, 2018
Objective
Increased
oxidative
stress
has
been
described
in
patients
with
Hashimoto’s
thyroiditis
(HT).
The
aim
of
the
present
study
was
to
investigate
whether
high
is
further
influenced
by
obesity
and
dietary
habits
euthyroid
women
HT.
Methods
Two
hundred
eighteen
consecutive
HT
were
studied
separated
two
groups;
102
thyroxine
replacement
114
without.
For
evaluation
stress,
total
lipid
peroxide
levels
serum
(TOS)
measured
recoded
as
‘high
TOS’
vs
‘medium/low
TOS’.
type
food
consumption
frequency
recorded.
binary
variables
considered;
normal
low
fruit
daily
sporadic
vegetable
consumption.
Results
‘High
more
frequent
under
(31.4%
14.7%,
OR
=
2.7,
95%
CI:
1.4–5.2).
prevalence
higher
among
overweight/obese
compared
BMI
(30.4%
12.5%,
3.1,
1.5–6.4).
Low
associated
increased
(30.6%
12.9%,
3.0,
1.4–6.2).
Sporadic
(29.9%
13.5%,
1.3–5.7).
examined
risk
factors
independent
additive
their
effect
on
TOS.
At
least
three
had
be
concomitantly
for
likelihood
significantly
elevated.
Conclusions
Oxidative
replacement.
Nevertheless,
BMI,
consumption,
all
contribute
maintaining
at
levels.
