DNA Damage and Obesity Among Faculty of Pharmacy Students DOI Open Access

Farah Natasha Zalizan,

Mizaton Hazizul Hasan,

Maziana Mahamood

et al.

Malaysian Journal of Medicine and Health Sciences, Journal Year: 2023, Volume and Issue: 19(s18), P. 52 - 59

Published: Dec. 22, 2023

Introduction: Obesity is a major concern on global scale, particularly in Malaysia. It causes physiological imbalance the regulation and normal functioning of adipose tissue, leading to other medical issues such as hyperglycaemia, dyslipidaemia, inflammation. These conditions trigger production oxidative stress, which worsened by decrease antioxidant defence systems obese patients. Methods: This study was conducted evaluate body mass index (BMI), waist-to-hip ratio (WHR), level subcutaneous fat whole body, trunk, leg, arm visceral subjects, their relationship with DNA damage parameters among students Faculty Pharmacy (n=89) Universiti Teknologi MARA (UiTM). assessed using Comet Assay. Results: No significant differences (p>0.05) tail length, moment, olive percentage were observed between groups, although greater value (mean ± SD) seen overweight group. There also no correlation anthropometric measurements (p>0.05). In summary, it can be concluded that there difference levels overweight/obese group BMI Conclusion: Further should understand mechanism/s contributed this condition.

Language: Английский

Aneuploidy in mammalian oocytes and the impact of maternal ageing DOI
Chloe Charalambous, Alexandre Webster, Melina Schuh

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(1), P. 27 - 44

Published: Sept. 6, 2022

Language: Английский

Citations

102
Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth DOI Open Access
Teofana Bizerea, Laura Pitulice,

Otilia Bizerea-Spiridon

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7276 - 7276

Published: July 2, 2024

Obesity is a worldwide increasing concern. Although in adults this easily estimated with the body mass index, children, who are constantly growing and whose bodies changing, reference points to assess weight status age gender, need corroboration complementary data, making their quantification highly difficult. The present review explores interaction spectrum of oxidative stress, selenium status, obesity children adolescents. Any factor related stress that triggers and, conversely, induces part vicious circle, complex chain mechanisms derive from each other reinforce serious health consequences. Selenium its compounds exhibit key antioxidant activity also have significant role nutritional evaluation obese children. balance intake, retention, metabolism emerges as vital aspect health, reflecting interactions between diet, obesity. Understanding whether contributor or consequence could inform interventions public strategies aimed at preventing managing an early age.

Language: Английский

Citations

7
Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran DOI Creative Commons
Parisa Kangari,

Tahereh Zarnoosheh Farahany,

Ali Golchin

et al.

Asian Pacific Journal of Cancer Prevention, Journal Year: 2018, Volume and Issue: 19(12), P. 3511 - 3515

Published: Dec. 1, 2018

Background: Breast cancer is caused by breast tissue malignant cells and it has become one of the main medical concerns with a socio-economic significance especially for women. Among multiple factors involved in initiation, progression, invasion cancer, oxidative stress plays an important role. Antioxidant status, lipid peroxidation, newly diagnosed patients were determined to find defined pattern these patients. Methods: The malondialdehyde (MDA) levels (as indicator peroxidation), glutathione peroxidase (GPX), superoxide dismutase (SOD) activities (n=38) controls assessed using blood samples. Results: MDA level SOD activity significantly higher compared healthy subjects group (p<0.05). Compared group, GPX decreased Conclusions: High peroxidation risk factor increased anion may be reason induction activity. Nevertheless, development progression cancer. Further studies on can lead more helpful approach management

Language: Английский

Citations

55
Interplay between diet-induced obesity and oxidative stress: Comparison between Drosophila and mammals DOI
Maria M. Bayliak, Oleksandra Abrat, Janet M. Storey

et al.

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Journal Year: 2018, Volume and Issue: 228, P. 18 - 28

Published: Oct. 30, 2018

Language: Английский

Citations

38
Association of dietary total antioxidant capacity to anthropometry in healthy women: A cross-sectional study DOI
Hadis Mozaffari, Elnaz Daneshzad, Bagher Larijani

et al.

Nutrition, Journal Year: 2019, Volume and Issue: 69, P. 110577 - 110577

Published: Aug. 28, 2019

Language: Английский

Citations

34
Reduction of DNA damage in peripheral lymphocytes of obese patients after bariatric surgery-mediated weight loss DOI Open Access
Ezgi Eyluel Bankoglu, Florian Seyfried,

Charlotte Arnold

et al.

Mutagenesis, Journal Year: 2017, Volume and Issue: 33(1), P. 61 - 67

Published: Nov. 23, 2017

Obesity is associated with several detrimental health consequences, among them an increased risk for development of cancer, and overall elevated mortality. Multiple factors like hyperinsulinemia, chronic microinflammation oxidative stress may be involved. The comet assay has been proven to very sensitive detection DNA damage used explore the relationship between overweight/obesity damage, but results are controversial. Very few investigations have performed correlate weight loss obese individuals possible reduction these studies not provided clear results. As currently, only surgical interventions (metabolic/bariatric surgery) enable substantial sustained in vast majority morbidly patients, we analyzed whole blood samples 56 subsequent patients prior, 6 12 months after bariatric surgery. No was observed analysis despite efficient loss, a significant Concurrently, ferric-reducing antioxidant power showed months. level oxidised glutathione lipid peroxidation products were at normalised conclusion, help diminish existing besides improving many other aspects patients.

Language: Английский

Citations

27
The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis DOI Creative Commons

Maria E. Giannakou,

Katerina Saltiki, Aimilia Mantzou

et al.

Endocrine Connections, Journal Year: 2018, Volume and Issue: 7(9), P. 990 - 997

Published: Sept. 1, 2018

Objective Increased oxidative stress has been described in patients with Hashimoto’s thyroiditis (HT). The aim of the present study was to investigate whether high is further influenced by obesity and dietary habits euthyroid women HT. Methods Two hundred eighteen consecutive HT were studied separated two groups; 102 thyroxine replacement 114 without. For evaluation stress, total lipid peroxide levels serum (TOS) measured recoded as ‘high TOS’ vs ‘medium/low TOS’. type food consumption frequency recorded. binary variables considered; normal low fruit daily sporadic vegetable consumption. Results ‘High more frequent under (31.4% 14.7%, OR = 2.7, 95% CI: 1.4–5.2). prevalence higher among overweight/obese compared BMI (30.4% 12.5%, 3.1, 1.5–6.4). Low associated increased (30.6% 12.9%, 3.0, 1.4–6.2). Sporadic (29.9% 13.5%, 1.3–5.7). examined risk factors independent additive their effect on TOS. At least three had be concomitantly for likelihood significantly elevated. Conclusions Oxidative replacement. Nevertheless, BMI, consumption, all contribute maintaining at levels.

Language: Английский

Citations

26
Gene polymorphisms and increased DNA damage in morbidly obese women DOI
Bruno Cesar Ottoboni Luperini,

D. C. Almeida,

Mariana Porto

et al.

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Journal Year: 2015, Volume and Issue: 776, P. 111 - 117

Published: Jan. 22, 2015

Language: Английский

Citations

23
Preventive effect of small‐leaved Kuding tea (Ligustrum robustum) on high‐diet‐induced obesity in C57BL/6J mice DOI Creative Commons

Ya Wu,

Jun Yang, Xiaojing Liu

et al.

Food Science & Nutrition, Journal Year: 2020, Volume and Issue: 8(8), P. 4512 - 4522

Published: July 8, 2020

Abstract Small‐leaved Kuding tea (SLKDT; Ligustrum robustum ) is a traditional Chinese tea. We systematically investigated the effect of SLKDT extract on obesity. SLKDT‐controlled weight gain in mice fed high‐fat diet. Tissue specimen results showed that alleviated liver damage and fat accumulation. Meanwhile, improved dyslipidemia by decreasing total cholesterol, triglycerides, low‐density lipoprotein cholesterol levels increasing high‐density levels. Furthermore, reduced alanine aminotransferase, alkaline phosphatase, aspartate transaminase serum tissues; decreased inflammatory cytokines, including interleukin (IL)‐1β, tumor necrosis factor‐α, interferon‐γ, IL‐6; increased anti‐inflammatory IL‐4 IL‐10. The quantitative PCR upregulated mRNA expressions peroxisome proliferator‐activated receptor (PPAR)‐α, lipase, carnitine palmitoyltransferase 1, 7 alpha hydroxylase downregulated PPAR‐γ CCAAT/enhancer‐binding protein‐alpha obese mouse livers to reduce adipocyte differentiation accumulation, promote oxidation, improve dyslipidemia, thereby inhibiting immune response alleviating injury. shows potential for preventing obesity regulating obesity‐related syndrome, so it possible be further developed as novel treatment fighting

Language: Английский

Citations

19
Neurobiological Mechanisms Modulating Emotionality, Cognition and Reward-Related Behaviour in High-Fat Diet-Fed Rodents DOI Open Access

Dorothea Ziemens,

Chadi Touma,

Virginie Rappeneau

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7952 - 7952

Published: July 19, 2022

Affective and substance-use disorders are associated with overweight obesity-related complications, which often due to the overconsumption of palatable food. Both high-fat diets (HFDs) psychostimulant drugs modulate neuro-circuitry regulating emotional processing metabolic functions. However, it is not known how they interact at behavioural level, whether lead overlapping changes in neurobiological endpoints. In this literature review, we describe impact HFDs on emotionality, cognition, reward-related behaviour rodents. We also outline effects HFD brain metabolism plasticity involving mitochondria. Moreover, possible overlap mechanisms produced by psychostimulants discussed. Our in-depth analysis published results revealed that have a clear underlying processes, largely dependent developmental period. apart from studies investigating maternal exposure HFDs, most involve only male Future research should examine biological female Further knowledge about molecular linking stress obesity crucial requirement translational using rodent models can significantly advance important search for risk-related biomarkers development clinical intervention strategies.

Language: Английский

Citations

9