Neural Circuitry of Wakefulness and Sleep

Neuron, Год журнала: 2017, Номер 93(4), С. 747 - 765

Опубликована: Фев. 1, 2017

Язык: Английский

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Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock

Cell, Год журнала: 2015, Номер 161(1), С. 84 - 92

Опубликована: Март 1, 2015

Язык: Английский

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The human stress response

Nature Reviews Endocrinology, Год журнала: 2019, Номер 15(9), С. 525 - 534

Опубликована: Июнь 27, 2019

Язык: Английский

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Melatonin as a Hormone: New Physiological and Clinical Insights

Endocrine Reviews, Год журнала: 2018, Номер 39(6), С. 990 - 1028

Опубликована: Сен. 12, 2018

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to humans. In vertebrates, besides produced peripheral tissues and acting as an autocrine paracrine signal, melatonin centrally synthetized by neuroendocrine organ, the pineal gland. Independently of considered species, hormone always during night its production secretory episode duration are directly dependent on length night. As tightly linked light/dark cycle, main hormonal systemic integrative action coordinate behavioral physiological adaptations environmental geophysical day season. The circadian signal daily regularity, contrast between concentrations, specially developed ways action. During episode, coordinates adaptive physiology through immediate effects primes responses prospective that will only appear at daytime, when absent. Similarly, annual history central nervous/endocrine system seasons come. Remarkably, maternal programs fetuses' behavior cope with cycle season after birth. These unique turn into biological time-domain–acting molecule. review focuses above considerations, proposes putative classification clinical dysfunctions, discusses general guidelines therapeutic use melatonin.

Язык: Английский

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Association between circadian rhythms and neurodegenerative diseases

The Lancet Neurology, Год журнала: 2019, Номер 18(3), С. 307 - 318

Опубликована: Фев. 12, 2019

Язык: Английский

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Social Jetlag, Chronotype, and Cardiometabolic Risk

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2015, Номер 100(12), С. 4612 - 4620

Опубликована: Ноя. 18, 2015

Shift work, which imposes a habitual disruption in the circadian system, has been linked to increased incidence of cardiometabolic diseases, and acute misalignment alters various metabolic processes. However, it remains unclear whether day-to-day dysregulation contributes these risks beyond poor sleep other behavioral characteristics.

Язык: Английский

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Mistimed sleep disrupts circadian regulation of the human transcriptome

Proceedings of the National Academy of Sciences, Год журнала: 2014, Номер 111(6)

Опубликована: Янв. 21, 2014

Significance Disruption of the timing sleep–wake cycle and circadian rhythms, such as occurs during jet lag shift work, leads to disordered physiological but what extent molecular elements rhythm generation are affected is not known. Here, we show that delaying sleep by 4 h for 3 consecutive days a sixfold reduction transcripts in human blood transcriptome just 1%, whereas, at same time, centrally driven melatonin affected. Genes processes included those core gene expression. The data have implications understanding negative health outcomes disruption cycle.

Язык: Английский

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Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals

Cold Spring Harbor Symposia on Quantitative Biology, Год журнала: 2015, Номер 80, С. 223 - 232

Опубликована: Янв. 1, 2015

Ueli Schibler1, Ivana Gotic1, Camille Saini1,2, Pascal Gos1, Thomas Curie3, Yann Emmenegger3, Flore Sinturel1, Pauline Gosselin1, Alan Gerber1,4, Fabienne Fleury-Olela1, Gianpaolo Rando1, Maud Demarque1 and Paul Franken3 1Department of Molecular Biology, University Geneva, CH-1211 Switzerland 2Laboratory Circadian Endocrinology, Geneva Hospitals, CH-1205 3Center Integrative Genomics, Lausanne, CH-1015 4Laboratory Biochemistry Rockefeller University, New York, York 10065 Correspondence: ueli.schibler{at}unige.ch

Язык: Английский

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The nuclear receptor REV‐ERBα is required for the daily balance of carbohydrate and lipid metabolism

The FASEB Journal, Год журнала: 2012, Номер 26(8), С. 3321 - 3335

Опубликована: Май 4, 2012

Mutations of clock genes can lead to diabetes and obesity. REV-ERBα, a nuclear receptor involved in the circadian clockwork, has been shown control lipid metabolism. To gain insight into role REV-ERBα energy homeostasis vivo, we explored daily metabolism carbohydrates lipids chow-fed, unfed, or high-fat-fed Rev-erbα−/− mice their wild-type littermates. Chow-fed displayed increased adiposity (2.5-fold) mild hyperglycemia (∼10%) without insulin resistance. Indirect calorimetry indicates that chow-fed utilize more fatty acids during daytime. A 24-h nonfeeding period animals favors further acid mobilization at expense glycogen utilization gluconeogenesis, triggering hypoglycemia hypothermia. High-fat feeding amplified metabolic disturbances, including expression lipogenic factors. Lipoprotein lipase (Lpl) gene, critical utilization/storage, is triggered liver night constitutively up-regulated (∼ 2-fold) muscle adipose tissue mice. We show CLOCK, (2-fold) mice, transactivate Lpl. Thus, overexpression Lpl facilitates contributes fat overload. This study demonstrates importance clock-driven balance highlights disruption as potential cause for syndrome.—Delezie, J., Dumont, S., Dardente, H., Oudart, Gréchez-Cassiau, A., Klosen, P., Teboul, M., Delaunay, F., Pévet, Challet, E. The required carbohydrate FASEB J. 26, 3321–3335 (2012). www.fasebj.org

Язык: Английский

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Circadian timing of metabolism in animal models and humans

Journal of Internal Medicine, Год журнала: 2015, Номер 277(5), С. 513 - 527

Опубликована: Янв. 20, 2015

Most living beings, including humans, must adapt to rhythmically occurring daily changes in their environment that are generated by the Earth's rotation. In course of evolution, these organisms have acquired an internal circadian timing system can anticipate environmental oscillations and thereby govern rhythmic physiology a proactive manner. mammals, coordinates virtually all physiological processes encompassing vigilance states, metabolism, endocrine functions cardiovascular activity. Research performed during past two decades has established almost every cell body possesses its own timekeeper. The resulting clock network is organized hierarchical A master pacemaker, located suprachiasmatic nucleus (SCN) hypothalamus, synchronized day photoperiod. turn, SCN determines phase cellular clocks peripheral organs through wide variety signalling pathways dependent on feeding cycles, temperature rhythms, oscillating bloodborne signals and, some organs, inputs nervous system. major purpose tissues temporal orchestration key metabolic processes, food processing (metabolism xenobiotic detoxification). Here, we review recent findings regarding molecular composition discuss implications for coordination metabolism health disease. We focus primarily disorders such as obesity type 2 diabetes, although misalignments (shiftwork or 'social jet lag') also been associated with aetiology human malignancies.

Язык: Английский

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