Опубликована: Июль 19, 2024

Oral cancer (OC) presents a significant global health burden with rising incidence rates. Despite advancements in diagnosis and treatments, the survival rate for OC patients, particularly those advanced or recurrent disease, remains low at approximately 20%. This poor prognosis is often due to small population of stem cells (CSCs) that are capable self-renewal immune evasion, thus playing pivotal roles proliferation, tumor initiation, progression, metastasis, therapy resistance. Exosomes, nano-sized extracellular vesicles (EVs), have emerged as crucial mediators cell-to-cell communication within microenvironment (TME). These carry diverse molecules such DNA, RNA, proteins, lipids, metabolites, influencing various cellular processes. Emerging evidence suggests CSC-derived EVs promoting progression metastasis maintaining balance between CSCs non-CSCs, which vital intracellular TME oral cancer. Recent reports indicate cell-derived (OCSC-EVs) influence stemness, angiogenesis, reoccurrence, drug Understanding OCSC-EVs could significantly improve diagnosis, prognosis, therapy. In this mini-review, we explore OCSC-derived exosomes cancer, examining their potential diagnostic prognostic biomarkers reflect CSC characteristics, delve into therapeutic implications, emphasizing However, despite promising potential, several challenges remain, including need standardize isolation characterization methods elucidate exosome-mediated mechanisms. Thus, comprehensive understanding pave way innovative strategies clinical outcomes patients.

Язык: Английский