Regulatory role and therapeutic prospect of lactate modification in cancer

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 17, 2025

Post-translational modifications (PTMs) of proteins refer to the process adding chemical groups, sugars, or other molecules specific residues target following their biosynthesis by ribosomes. PTMs play a crucial role in processes such as signal transduction, epigenetics, and disease development. Lactylation is newly discovered PTM that, due its close association with lactate—the end product glycolytic metabolism—provides new perspective on connection between cellular metabolic reprogramming epigenetic regulation. Studies have demonstrated that lactylation plays significant tumor progression associated poor clinical prognosis. Abnormal histone can influence gene expression both cells immune cells, thereby regulating immunosuppression. non-histone also modulate proliferation drug resistance. This review summarizes latest research progress field lactylation, highlighting roles mechanisms tumorigenesis, development, microenvironment, It explores potential application value tumor-targeted therapy combined immunotherapy.

Язык: Английский

Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance

Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)

Опубликована: Март 18, 2025

In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature solid tumors strongly associated with poor prognosis in patients. Another significant portion development acquired drug attributed to tumor stemness. Cancer stem cells (CSCs), small cell subset self-renewal proliferative abilities, are crucial for initiation, metastasis, intra-tumoral heterogeneity. Studies have shown association between hypoxia CSCs context resistance. Recent studies reveal strong link stemness, which together promote survival progression during treatment. This review elucidates interplay CSCs, well their correlation therapeutic drugs. Targeting pivotal genes stemness holds promise novel therapeutics combat

Язык: Английский

Molecular mechanisms and clinical significance of perineural invasion in malignancies: the pivotal role of tumor-associated Schwann cells in cancer progression and metastasis

Medical Oncology, Год журнала: 2025, Номер 42(5)

Опубликована: Апрель 21, 2025

Язык: Английский