Frontiers in Human Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 3, 2025
As
life
becomes
more
stressful,
neurological
disorders,
psychiatric
and
comorbidities
of
the
two
are
becoming
a
concern.
Multiple
neuropsychiatric
disorders
share
same
mental
somatic
dysfunction
may
involve
common
brain
circuits
mechanistic
targets.
Music
therapy,
as
an
art
form
with
proven
efficacy,
low
cost
few
side
effects,
is
promoted
for
use
in
interventions
disorders.
This
be
closely
related
to
release
signaling
molecules
such
monoamine
neurotransmitters,
glutamatergic
system,
gut-microbiota-brain
axis,
pro-inflammatory
cytokines
endogenous
opioid
peptide
system.
However,
fewer
studies
have
mentioned
main
targets
music
promote
functional
changes
regions.
Therefore,
this
paper
review
mechanisms
by
which
therapy
interacts
prefrontal
cortex-hippocampus-amygdala
circuit
through
aforementioned
molecules.
It
also
hypothesized
that
glial
cells,
mitochondria
microRNAs
microscopic
musical
intervention
The
aim
give
new
ideas
future
research
into
biological
Molecular Metabolism,
Год журнала:
2023,
Номер
74, С. 101755 - 101755
Опубликована: Июнь 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(6), С. 5914 - 5914
Опубликована: Март 21, 2023
Alpha-Synuclein
(α-Syn)
is
one
of
the
most
important
molecules
involved
in
pathogenesis
Parkinson’s
disease
and
related
disorders,
synucleinopathies,
but
also
several
other
neurodegenerative
disorders
with
a
more
elusive
role.
This
review
analyzes
activities
α-Syn,
different
conformational
states,
monomeric,
oligomeric
fibrils,
relation
to
neuronal
dysfunction.
The
damage
induced
by
α-Syn
various
conformers
will
be
analyzed
its
capacity
spread
intracellular
aggregation
seeds
prion-like
mechanism.
In
view
prominent
role
inflammation
virtually
all
activity
illustrated
considering
influence
on
glial
reactivity.
We
others
have
described
interaction
between
general
cerebral
dysfunctional
α-Syn.
Differences
microglia
astrocyte
activation
been
observed
when
vivo
presence
oligomers
has
combined
lasting
peripheral
inflammatory
effect.
reactivity
was
amplified,
while
astrocytes
were
damaged
double
stimulus,
opening
new
perspectives
for
control
synucleinopathies.
Starting
from
our
studies
experimental
models,
we
extended
perspective
find
useful
pointers
orient
future
research
potential
therapeutic
strategies
disorders.
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
The
increasing
life
expectancy
has
led
to
a
higher
incidence
of
age-related
neurodegenerative
conditions.
Within
this
framework,
neuroinflammation
emerges
as
significant
contributing
factor.
It
involves
the
activation
microglia
and
astrocytes,
leading
release
pro-inflammatory
cytokines
chemokines
infiltration
peripheral
leukocytes
into
central
nervous
system
(CNS).
These
instances
result
in
neuronal
damage
neurodegeneration
through
activated
nucleotide-binding
domain
leucine-rich
repeat
containing
(NLR)
family
pyrin
protein
3
(NLRP3)
nuclear
factor
kappa
B
(NF-kB)
pathways
decreased
erythroid
2-related
2
(Nrf2)
activity.
Due
limited
effectiveness
regarding
inhibition
neuroinflammatory
targets
using
conventional
drugs,
there
is
challenging
growth
search
for
innovative
therapies
alleviating
CNS
diseases
or
even
before
their
onset.
Our
results
indicate
that
interventions
focusing
on
Interleukin-Driven
Immunomodulation,
Chemokine
(CXC)
Receptor
Signaling
Expression,
Cold
Exposure,
Fibrin-Targeted
strategies
significantly
promise
mitigate
processes.
approaches
demonstrate
potential
anti-neuroinflammatory
effects,
addressing
conditions
such
Multiple
Sclerosis,
Experimental
autoimmune
encephalomyelitis,
Parkinson’s
Disease,
Alzheimer’s
Disease.
While
findings
are
promising,
immunomodulatory
often
face
limitations
due
Immune-Related
Adverse
Events.
Therefore,
conduction
randomized
clinical
trials
matter
mandatory,
will
pave
way
promising
future
development
new
medicines
with
specific
therapeutic
targets.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(14), С. 4130 - 4130
Опубликована: Июль 15, 2024
Neurodegenerative
diseases,
such
as
Alzheimer’s
disease
(AD)
and
Parkinson’s
(PD),
are
severe
age-related
disorders
with
complex
multifactorial
causes.
Recent
research
suggests
a
critical
link
between
neurodegeneration
the
gut
microbiome,
via
gut–brain
communication
pathway.
This
review
examines
role
of
trimethylamine
N-oxide
(TMAO),
microbiota-derived
metabolite,
in
development
AD
PD,
investigates
its
interaction
microRNAs
(miRNAs)
along
this
bidirectional
TMAO,
which
is
produced
from
dietary
metabolites
like
choline
carnitine,
has
been
linked
to
increased
neuroinflammation,
protein
misfolding,
cognitive
decline.
In
AD,
elevated
TMAO
levels
associated
amyloid-beta
tau
pathologies,
blood–brain
barrier
disruption,
neuronal
death.
can
cross
promote
aggregation
amyloid
proteins.
Similarly,
affects
alpha-synuclein
conformation
aggregation,
hallmark
PD.
also
activates
pro-inflammatory
pathways
NF-kB
signaling,
exacerbating
neuroinflammation
further.
Moreover,
modulates
expression
various
miRNAs
that
involved
neurodegenerative
processes.
Thus,
microbiome–miRNA–brain
axis
represents
newly
discovered
mechanistic
dysbiosis
neurodegeneration.
MiRNAs
regulate
key
oxidative
stress,
death,
contributing
progression.
As
direct
consequence,
specific
miRNA
signatures
may
serve
potential
biomarkers
for
early
detection
monitoring
PD
aims
elucidate
interrelationships
microbiota,
trimethylamine-N-oxide
(miRNAs),
central
nervous
system,
implications
these
connections
diseases.
context,
an
overview
current
neuroradiology
techniques
available
studying
animal
models
used
investigate
intricate
pathologies
will
be
provided.
summary,
bulk
evidence
supports
concept
modulating
pathway
through
changes,
manipulation
and/or
miRNA-based
therapies
offer
novel
approaches
implementing
treatment
debilitating
neurological
disorders.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Март 7, 2025
Abstract
Macrophages
are
immune
cells
belonging
to
the
mononuclear
phagocyte
system.
They
play
crucial
roles
in
defense,
surveillance,
and
homeostasis.
This
review
systematically
discusses
types
of
hematopoietic
progenitors
that
give
rise
macrophages,
including
primitive
progenitors,
erythro-myeloid
stem
cells.
These
have
distinct
genetic
backgrounds
developmental
processes.
Accordingly,
macrophages
exhibit
complex
diverse
functions
body,
phagocytosis
clearance
cellular
debris,
antigen
presentation,
response,
regulation
inflammation
cytokine
production,
tissue
remodeling
repair,
multi-level
regulatory
signaling
pathways/crosstalk
involved
homeostasis
physiology.
Besides,
tumor-associated
a
key
component
TME,
exhibiting
both
anti-tumor
pro-tumor
properties.
Furthermore,
functional
status
is
closely
linked
development
various
diseases,
cancer,
autoimmune
disorders,
cardiovascular
disease,
neurodegenerative
metabolic
conditions,
trauma.
Targeting
has
emerged
as
promising
therapeutic
strategy
these
contexts.
Clinical
trials
macrophage-based
targeted
drugs,
immunotherapies,
nanoparticle-based
therapy
were
comprehensively
summarized.
Potential
challenges
future
directions
targeting
also
been
discussed.
Overall,
our
highlights
significance
this
versatile
cell
human
health
which
expected
inform
research
clinical
practice.
Biomolecules,
Год журнала:
2025,
Номер
15(1), С. 149 - 149
Опубликована: Янв. 19, 2025
Parkinson’s
disease
(PD)
is
a
prevalent
neurodegenerative
disorder
marked
by
the
progressive
degeneration
of
midbrain
dopaminergic
neurons
and
resultant
locomotor
dysfunction.
Despite
over
two
centuries
recognition
as
chronic
disease,
exact
pathogenesis
PD
remains
elusive.
The
onset
progression
involve
multiple
complex
pathological
processes,
with
dysfunctional
autophagy
elevated
oxidative
stress
serving
critical
contributors.
Notably,
emerging
research
has
underscored
interplay
between
in
pathogenesis.
Given
limited
efficacy
therapies
targeting
either
dysfunction
or
stress,
it
crucial
to
elucidate
intricate
mechanisms
governing
their
develop
more
effective
therapeutics.
This
review
overviews
role
nuclear
factor
erythroid
2-related
2
(Nrf2),
pivotal
transcriptional
regulator
orchestrating
cellular
defense
against
these
processes.
By
elucidating
key
processes
PD,
this
will
deepen
our
comprehensive
understanding
multifaceted
underlying
may
uncover
potential
strategies
for
its
prevention
treatment.
Cells,
Год журнала:
2024,
Номер
13(3), С. 286 - 286
Опубликована: Фев. 5, 2024
The
key
to
the
effective
treatment
of
neurodegenerative
disorders
is
a
thorough
understanding
their
pathomechanism.
Neurodegeneration
and
neuroinflammation
are
mutually
propelling
brain
processes.
An
impairment
glymphatic
system
function
in
neurodegeneration
contributes
progression
pathological
question
arises
as
how
related.
This
review
highlights
direct
indirect
influence
these
two
seemingly
independent
Protein
aggregates,
characteristic
feature
neurodegeneration,
correlated
with
clearance
neuroinflammation.
Glial
cells
cannot
be
overlooked
when
considering
neuroinflammatory
Astrocytes
essential
for
functioning
play
crucial
role
inflammatory
responses
central
nervous
system.
It
imperative
acknowledge
significance
AQP4,
protein
that
exhibits
high
degree
polarization
astrocytes
AQP4
influences
processes
have
not
yet
been
clearly
delineated.
Another
interesting
issue
gut–brain
axis
microbiome,
which
potentially
impact
discussed
A
discussion
correlation
between
may
contribute
exploring
pathomechanism
neurodegeneration.
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(7), С. 1533 - 1547
Опубликована: Март 20, 2024
Neuroinflammation
plays
a
crucial
role
in
the
development
of
neurodegenerative
protein
misfolding
disorders.
This
category
progressive
diseases
includes,
but
is
not
limited
to,
Alzheimer's
disease,
Parkinson's
and
prion
diseases.
Shared
pathogenesis
involves
accumulation
misfolded
proteins,
chronic
neuroinflammation,
synaptic
dysfunction,
ultimately
leading
to
irreversible
neuronal
loss,
measurable
cognitive
deficits,
death.
Presently,
there
are
few
no
effective
treatments
halt
advancement
We
hypothesized
that
directly
targeting
neuroinflammation
by
downregulating
transcription
factor,
NF-κB,
inflammasome
protein,
NLRP3,
would
be
neuroprotective.
To
achieve
this,
we
used
cocktail
RNA
therapeutics
(SB_NI_112)
shown
brain-penetrant,
nontoxic,
inhibitors
both
NF-κB
NLRP3.
utilized
mouse-adapted
strain
as
model
for
assess
aggregation
glial
inflammation,
lifespan.
Prion-diseased
mice
were
treated
either
intraperitoneally
or
intranasally
with
SB_NI_112.
Behavioral
deficits
significantly
protected
this
combination
NLRP3
downregulators.
Treatment
reduced
against
prevented
spongiotic
change,
rescued
lengthened
lifespan
prion-diseased
mice.
have
identified
systemic
pharmacologic
downregulates
prevents
death,
slows
progression
Though
mouse
models
do
always
predict
human
patient
success
study
was
due
sample
size
number
dosing
methods
utilized,
these
findings
serve
proof
principle
continued
translation
therapeutic
SB_NI_112
disease
other
Based
on
murine
model,
will
continue
testing
variety
models,
including
disease.
Exploration of Neuroprotective Therapy,
Год журнала:
2024,
Номер
unknown, С. 119 - 147
Опубликована: Апрель 16, 2024
Degeneration
and
dysfunction
of
neurons
in
the
brain
are
hallmarks
neurodegenerative
diseases.
Over
past
decades,
significant
efforts
have
been
devoted
to
development
validation
biomarkers
for
The
range
diversity
central
nervous
system
(CNS)
diseases
has
continued
expand,
encompassing
biofluid-based
sources
such
as
blood
or
cerebrospinal
fluid
(CSF),
nucleic
acids,
tissues,
imaging.
While
imaging
tissue
biopsy-based
markers
continually
being
identified
their
applications
expanding,
they
do
limitations
compared
with
RNA
protein
biomarkers.
This
review
comprehensively
summarizes
various
biomarkers,
including
microRNA
(miRNA),
long
noncoding
(lncRNA),
circulating
miRNA
(cimiRNA),
proteins,
context
CNS
disorders.
In
addition,
emphasizes
existing
challenges
associated
use
both
clinical
practice
research
on
conclusion,
this
provides
an
insightful
overview
diseases,
underscoring
crucial
role
biomarker
combating
these
debilitating
conditions.
article
also
highlights
future
related
implementation
novel
trials,
thereby
contributing
ongoing
advance
understanding
management