Ageing
is
an
inevitable
biological
process
that
impacts
the
immune
system,
leading
to
immunosenescence
and
inflammaging,
which
contribute
increased
susceptibility
infections,
autoimmune
diseases
cancers
in
individuals
over
age
of
65.
This
review
focuses
on
ageing
lymph
node
stromal
cells
(LNSCs),
are
crucial
for
maintaining
(LN)
structure
function.
Age-related
changes
LNs,
such
as
fibrosis
lipomatosis,
disrupt
LN
architecture
reduce
cell
recruitment
function,
impairing
responses
infections
vaccinations.
The
discusses
structural
functional
decline
various
LNSC
subsets,
including
fibroblastic
reticular
(FRCs),
lymphatic
endothelial
(LECs)
blood
(BECs),
highlighting
their
roles
activation
homeostasis.
Potential
strategies
restore
aged
enhancing
during
vaccination
using
senotherapeutics,
explored.
Outstanding
questions
regarding
mechanisms
how
stroma
might
impact
disorders
also
addressed.
aims
stimulate
further
research
into
characterisation
LNSCs
development
therapeutic
interventions
improve
function
older
adults.
Foods,
Год журнала:
2025,
Номер
14(3), С. 347 - 347
Опубликована: Янв. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
Cytokine & Growth Factor Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Population
ageing
is
increasing
in
prevalence
most
developed
countries.
Ageing
the
decline
of
functional
properties
at
cellular,
tissue,
and
organ
level.
Biochemical
changes
that
occur
all
organisms
experience
biological
are
referred
to
as
"Hallmarks
ageing".
Inflammation
a
common
denominator
hallmarks
ageing,
being
mechanistically
involved
age-related
health
consequences.
Inflamm-ageing
refers
inflammatory
immune
systems
which
somehow
drive
process
towards
healthy
or
unhealthy
ageing.
Current
evidences,
support
that,
reversing
pro-inflammatory
status
inflamm-ageing,
able
modulate
associated
with
increased
levels
molecules
(e.g.
cytokines,
chemokines),
ultimately
producing
chronic
low-grade
state
typically
observed
older
individuals.
It
commonly
accepted
balance
between
pro-
anti-inflammatory
cytokines/chemokines
one
factors
determining
whether
occurs.
Malnutrition
nutritional
imbalances,
highly
prevalent
elderly,
playing
role
driving
immunoactive
molecules.
In
particular,
malnutrition
major
risk
factor
for
sarcopenia,
phenomenon
characterized
by
loss
muscle
mass,
often
basis
frailty.
Given
close
relationship
there
also
evidence
link
Indeed,
cytokine/chemokine
elderly
patients
were
demonstrated.
The
demonstration
specific
cytokines
play
modulating
appetite
nutrient
sensing
taste
reception,
provided
further
existence
nutrition
shaping
trajectory
present
review
will
overview
current
supporting
circulating
chemokines
inflammation,
malnutrition.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 12, 2024
Abstract
The
reciprocal
relationship
between
aging
and
alterations
in
the
gut
microbiota
is
a
subject
of
ongoing
research.
While
role
bacteria
microbiome
well-documented,
specific
changes
composition
methanogens
during
extreme
impact
high
methane
production
general
on
health
remain
unclear.
To
address
these
questions,
we
analyzed
metagenomic
data
from
stool
samples
young
adults
(n=127,
Age:
19-59
y),
older
(n=86),
centenarians
(n=34,
age:
100-109
years).
Our
findings
reveal
compelling
link
age
prevalence
methanogen
phenotype,
while
overall
archaeal
diversity
diminishes.
Surprisingly,
appears
more
akin
to
that
younger
adults,
showing
an
increase
Methanobrevibacter
smithii
,
rather
than
Ca.
M.
intestini.
Remarkably,
intestini
emerged
as
central
player
network
stability
paving
way
for
centenarians.
Notably,
exhibit
highly
complex
stable
two
with
other
bacteria.
Furthermore,
mutual
exclusion
Lachnospiraceae
throughout
all
groups
suggests
communities
may
compensate
age-related
drop
by
co-occurring
butyrate-producing
Oscillospiraceae.
This
study
underscores
crucial
human
physiology
aging.
It
highlights
shifts
composition,
emphasizing
significance
partnership
enhanced
potential
longevity.
Cells,
Год журнала:
2024,
Номер
13(5), С. 390 - 390
Опубликована: Фев. 24, 2024
Aging
populations
worldwide
are
placing
age-related
diseases
at
the
forefront
of
research
agenda.
The
therapeutic
potential
natural
substances,
especially
propolis
and
its
components,
has
led
to
these
products
being
promising
agents
for
alleviating
several
cellular
molecular-level
changes
associated
with
diseases.
With
this
in
mind,
scientists
have
introduced
a
contextual
framework
guide
future
aging
research,
called
hallmarks
aging.
This
encompasses
various
mechanisms
including
genomic
instability,
epigenetic
changes,
mitochondrial
dysfunction,
inflammation,
impaired
nutrient
sensing,
altered
intercellular
communication.
Propolis,
rich
array
bioactive
compounds,
functions
as
potent
functional
food,
modulating
metabolism,
gut
microbiota,
immune
response,
offering
significant
health
benefits.
Studies
emphasize
propolis'
properties,
such
antitumor,
cardioprotective,
neuroprotective
effects,
well
ability
mitigate
oxidative
stress,
DNA
damage,
pathogenic
bacteria
growth.
article
underscores
current
scientific
evidence
supporting
role
controlling
molecular
characteristics
linked
hallmarks,
hypothesizing
geroscience
research.
aim
is
discover
novel
strategies
improve
quality
life
older
individuals,
addressing
existing
deficits
perspectives
area.
Cells,
Год журнала:
2024,
Номер
13(6), С. 550 - 550
Опубликована: Март 21, 2024
This
review
discusses
the
relationship
between
cellular
senescence
and
radiation
exposure.
Given
wide
range
of
ionizing
sources
encountered
by
people
in
professional
medical
spheres,
as
well
influence
natural
background
radiation,
question
effect
on
biological
processes,
particularly
aging
remains
highly
relevant.
The
parallel
radiation-induced
reveals
common
aspects
underlying
these
processes.
Based
recent
scientific
data,
key
points
effects
processes
associated
with
aging,
such
genome
instability,
mitochondrial
dysfunction,
altered
expression
miRNAs,
epigenetic
profile,
manifestation
senescence-associated
secretory
phenotype
(SASP),
are
discussed.
Unraveling
molecular
mechanisms
can
make
a
valuable
contribution
to
understanding
genetic
basis
age-associated
diseases
context
environmental
Cells,
Год журнала:
2024,
Номер
13(17), С. 1413 - 1413
Опубликована: Авг. 24, 2024
The
α-Klotho
protein
(hereafter
Klotho)
is
an
obligate
coreceptor
for
fibroblast
growth
factor
23
(FGF23).
It
produced
in
the
kidneys,
brain
and
other
sites.
Klotho
insufficiency
causes
hyperphosphatemia
anomalies.
Importantly,
it
associated
with
chronic
pathologies
(often
age-related)
that
have
inflammatory
component.
This
includes
atherosclerosis,
diabetes
Alzheimer's
disease.
Its
mode
of
action
these
diseases
not
well
understood,
but
inhibits
or
regulates
multiple
major
pathways.
has
a
membrane
form
soluble
(s-Klotho).
Cytosolic
postulated
characterized.
s-Klotho
endocrine
properties
are
incompletely
elucidated.
binds
to
FGF
receptor
1c
(FGFR1c)
widely
expressed
(including
endothelial
cells).
also
attaches
FGF23,
FGF23/Klotho
FGFRs.
Thus,
might
be
roaming
FGF23
coreceptor,
functions.
Notably,
(cell-bound
soluble)
counteracts
inflammation
appears
mitigate
related
aging
(inflammaging).
NF-κB
NLRP3
inflammasome.
inflammasome
requires
priming
by
produces
active
IL-1β,
pores
cell
death
(pyroptosis).
In
accord,
countered
injury
induced
toxins,
damage-associated
molecular
patterns
(DAMPs),
cytokines,
reactive
oxygen
species
(ROS).
blocks
TGF-β
Wnt
ligands,
which
lessens
fibrotic
Low
loss
muscle
mass
(sarcopenia),
as
occurs
diseases.
counters
inhibitory
effects
myostatin
on
muscle,
reduces
inflammation,
improves
repair
following
injury.
inhibition
factors
may
protective
diabetic
retinopathy
age-related
macular
degeneration
(AMD).
review
examines
functions
especially
potential
applications.
HA
(hyaluronan)
has
been
considered
in
recent
years
as
a
naturally
occurring
modifiable
gel-like
scaffold
that
the
capability
to
absorb
and
release
drugs
over
an
extended
period
of
time
making
it
suitable
potential
chemotherapeutic
delivery
agent.
Considering
limited
treatment
options
available
glioblastoma,
this
review,
we
discuss
novel
utilisation
ultra-high
molecular
weight
HA-originally
identified
mechanism
for
maintaining
longevity
naked
mole-rat-as
both
protective
extracellular
matrix-optimizing
colloidal
scaffold,
means
deliver
therapy
resected
brain
tumours.
The
unique
properties
form
cross-linked
gel
indicate
future
use
prevention
proliferative-based
inflammation-driven
disease.
