Neurodegenerative diseases and catechins: (−)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 1, 2024
Catechins,
a
class
of
phytochemicals
found
in
various
fruits
and
tea
leaves,
have
garnered
attention
for
their
diverse
health-promoting
properties,
including
potential
combating
neurodegenerative
diseases.
Among
these
catechins,
(-)-epigallocatechin-3-gallate
(EGCG),
the
most
abundant
polyphenol
green
tea,
has
emerged
as
promising
therapeutic
agent
due
to
its
potent
antioxidant
anti-inflammatory
effects.
Chronic
neuroinflammation
oxidative
stress
are
key
pathological
mechanisms
diseases
such
Alzheimer's
disease
(AD)
Parkinson's
(PD).
EGCG
neuroprotective
efficacy
scavenging
free
radicals,
reducing
attenuating
neuroinflammatory
processes.
This
review
discusses
molecular
EGCG's
anti-oxidative
chronic
neuroinflammation,
emphasizing
effects
on
autoimmune
responses,
neuroimmune
system
interactions,
focusing
related
AD
PD.
By
elucidating
action
impact
processes,
this
underscores
intervention
AD,
PD,
possibly
other
Overall,
emerges
natural
compound
stress,
offering
novel
avenues
strategies
treatment
disorders.
Язык: Английский
Mechanisms of comorbidity between Alzheimer's disease and pain
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
21(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Clinical
studies
have
revealed
a
significant
correlation
between
pain
and
neurodegenerative
diseases,
particularly
Alzheimer's
disease
(AD).
However,
due
to
cognitive
speech
impairments,
AD
patients,
especially
those
in
moderate
severe
stages,
are
often
overlooked
management.
The
challenges
obtaining
pain‐related
information
from
this
population
exacerbate
the
issue.
Although
recent
clinical
research
has
increasingly
recognized
comorbidity
of
pain,
pathological
alterations
interactive
mechanisms
underlying
relationship
remain
inadequately
explored.
This
review
provides
comprehensive
analysis
features
with
without
comorbidity.
It
examines
processes,
including
neuroinflammation,
peripheral‐central
immune
interactions,
neurotransmitter
dynamics.
Furthermore,
it
highlights
current
assessment
management
strategies
patients.
By
offering
theoretical
framework,
aims
support
development
effective
approaches
serve
as
reference
for
interventions
targeting
AD‐associated
pain.
Highlights
CP
encompasses
multiple
interrelated
biological
pathways,
such
neurodegeneration
inflammatory
responses.
damage
neurons
synapses
patients
influences
brain
regions
responsible
processing
thereby
reducing
response.
Neuroinflammation
plays
vital
role
both
CP.
Enhanced
responses
an
impact
on
CNS
promote
sensitization.
Common
exist
CP,
influencing
cognition,
emotion,
perception.
Язык: Английский
Identification of Potential Intervention Targets Involved in Prior Exercise that Attenuates Peripheral Neuropathic Pain by Integrating Transcriptome and Whole-genome Bisulfite Sequencing Analyses
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Язык: Английский
CD8+T cell infiltration-associated barrier function of brain endothelial cells is enhanced by Astragalus polysaccharides via inhibiting PI3K/AKT signaling pathway
Journal of Leukocyte Biology,
Год журнала:
2024,
Номер
117(1)
Опубликована: Сен. 3, 2024
Pathogenic
CD8+T
cells
play
an
essential
role
in
neuroinflammation
and
neural
injury,
which
leads
to
the
progression
of
inflammatory
neurological
disorders.
Thus,
blocking
infiltration
is
necessary
for
treatment
neuroinflammatory
diseases.
Our
previous
study
demonstrated
that
astragalus
polysaccharide
(APS)
could
significantly
reduce
experimental
autoimmune
encephalomyelitis
mice.
However,
mechanism
by
APS
suppresses
cell
remains
elusive.
In
this
study,
we
further
found
lipopolysaccharide
(LPS)-induced
model.
Furthermore,
established
mouse
brain
endothelial
(bEnd.3)
injury
model
interleukin-1β
or
LPS
vitro.
The
results
showed
downregulated
expression
vascular
adhesion
molecule1
decrease
bEnd.3
cells.
also
upregulated
zonula
occludens-1
cadherin
transendothelial
migration
PI3K/AKT
signaling
pathway
might
mediate
protective
effect
on
against
injury.
addition,
integrity
LPS-induced
summary,
our
indicate
can
peripheral
via
enhancing
barrier
function
cells;
it
may
be
a
potential
prevention
Язык: Английский
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain‐induced cognitive impairment via microglial DUSP6 pathway in rats
The FASEB Journal,
Год журнала:
2024,
Номер
38(21)
Опубликована: Ноя. 5, 2024
Abstract
Approximately
50%
of
patients
with
chronic
neuropathic
pain
experience
cognitive
impairment,
which
negatively
impacts
their
quality
life.
The
cannabinoid
type
2
receptor
(CB2R)
may
be
involved
in
hippocampal
processes.
However,
its
role
pain‐induced
impairment
remains
elusive.
Spared
nerve
injury
(SNI)
was
used
to
induce
rats,
while
the
novel‐object
recognition
test
and
Y‐maze
were
employed
assess
function.
Immunofluorescence,
western
blotting,
stereotaxic
microinjection
utilized
elucidate
potential
mechanisms.
We
observed
a
reduction
mechanical
threshold
SNI
rats.
This
accompanied
by
tendency
for
microglia
adopt
pro‐inflammatory
functions.
Notably,
no
changes
detected
CB2R
expression.
downregulation
endogenous
ligands
AEA
2‐AG
evident.
Hippocampal
agonist
mitigated
correlated
anti‐inflammatory
Additionally,
SNI‐induced
activation
p‐ERK/NFκB
pathway
hippocampus.
Activation
reversed
this
process
upregulating
DUSP6
expression
microglia.
effects
elicited
could
inhibited
through
microglial
via
adeno‐associated
virus
(AAV)
microinjection.
Conversely,
overexpression
using
AAV
ameliorated
deficits
remained
unaffected
administration
antagonist.
Our
findings
demonstrate
that
can
mitigate
modulation
DUSP6/ERK/NFκB
pathway.
Язык: Английский
Therapeutic potential of liver X receptor beta in depression and anxiety
Brain medicine :,
Год журнала:
2024,
Номер
unknown, С. 1 - 4
Опубликована: Окт. 4, 2024
Liver
X
receptors
(LXRs),
particularly
LXRβ,
are
emerging
as
crucial
players
in
the
translation
of
basic
neuroscience
to
clinical
psychiatry.
These
nuclear
receptor
transcription
factors,
initially
known
for
their
roles
cholesterol
metabolism
and
inflammation,
now
revealing
promising
connections
between
molecular
mechanisms
psychiatric
symptoms.
This
review
highlights
recent
breakthroughs
understanding
LXRβ's
regulation
function
behaviors
relevant
depression
anxiety,
derived
from
studies
using
animal
paradigms
that
capture
specific
features
these
disorders.
We
explore
how
preclinical
findings
shaping
our
comprehension
mood-related
at
level
potentially
paving
way
innovative
therapeutic
strategies.
As
a
ligand-activated
factor,
LXRβ
represents
novel
target
drug
development,
bridging
gap
bench
discoveries
bedside
treatments
neuropsychiatric
discuss
challenges
opportunities
translating
research
into
interventions,
emphasizing
potential
personalized
medicine
approaches
bench-to-bedside
article
underscores
importance
advancing
treatment
complex
mental
health
conditions,
while
acknowledging
nuanced
interpretation
required
when
extrapolating
human
Язык: Английский