Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
Polyphenols,
naturally
occurring
phytonutrients
found
in
plant-based
foods,
have
attracted
significant
attention
for
their
potential
therapeutic
effects
neurological
diseases
and
neuroinflammation.
These
compounds
possess
diverse
neuroprotective
capabilities,
including
antioxidant,
anti-inflammatory,
anti-amyloid
properties,
which
contribute
to
mitigating
the
progression
of
neurodegenerative
conditions
such
as
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
Dementia,
Multiple
Sclerosis
(MS),
Stroke,
Huntington's
(HD).
Polyphenols
been
extensively
studied
ability
regulate
inflammatory
responses
by
modulating
activity
pro-inflammatory
genes
influencing
signal
transduction
pathways,
thereby
reducing
neuroinflammation
neuronal
death.
Additionally,
polyphenols
shown
promise
various
cellular
signaling
pathways
associated
with
viability,
synaptic
plasticity,
cognitive
function.
Epidemiological
clinical
studies
highlight
polyphenol-rich
diets
decrease
risk
alleviate
symptoms
disorders
Furthermore,
demonstrated
through
regulation
key
Akt,
Nrf2,
STAT,
MAPK,
play
critical
roles
neuroprotection
body's
immune
response.
This
review
emphasizes
growing
body
evidence
supporting
combating
neurodegeneration
neuroinflammation,
well
enhancing
brain
health.
Despite
substantial
promising
hypotheses,
further
research
investigations
are
necessary
fully
understand
role
establish
them
advanced
targets
age-related
neuroinflammatory
conditions.
Язык: Английский
Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 22, 2025
Parkinson’s
disease
is
a
progressive
neurodegenerative
that
destroys
substantia
nigra
dopaminergic
neurons,
causing
tremors,
bradykinesia,
rigidity,
and
postural
instability.
Current
treatment
approaches
primarily
focus
on
symptom
management,
employing
pharmacological,
non-pharmacological,
surgical
methods.
However,
these
treatments
often
result
in
fluctuating
symptoms,
side
effects,
progression.
Here,
the
authors
have
reviewed
emerging
field
of
nanomedicine
as
promising
path
for
treatment,
emphasizing
its
potential
to
overcome
limitations
traditional
therapies.
Nanomedicine
utilizes
nanoparticles
targeted
drug
delivery,
leveraging
their
small
size
high
surface
area
volume
ratio
cross
blood-brain
barrier
deliver
therapeutic
agents
directly
affected
brain
regions.
Various
nanoparticles,
including
lipid-based,
polymeric,
metallic,
carbon-based,
shown
treatment.
Additionally,
nanocarrier
systems
like
liposomes,
nanogels,
dendrimers,
solid
lipid
offer
controlled
sustained
release
agents,
enhancing
bioavailability
reducing
effects.
This
review
provides
insights
into
pathophysiology
disease,
highlighting
mechanisms
neurodegeneration,
role
alpha-synuclein,
disruption
pathways.
It
further
discusses
application
gene
therapy
conjunction
with
interventions.
Язык: Английский
Green Tea Polyphenol Epigallocatechin-3-gallate Mediates an Antioxidant Response via Nrf2 Pathway in Heat-Stressed Poultry: A Review
Poultry Science,
Год журнала:
2025,
Номер
104(5), С. 105071 - 105071
Опубликована: Март 20, 2025
Heat
stress
is
a
critical
challenge
in
the
poultry
industry.
It
arises
when
birds
are
exposed
to
elevated
ambient
temperatures
beyond
their
thermoneutral
zone,
often
exacerbated
by
high
humidity
and
inadequate
ventilation.
This
condition
disrupts
birds'
ability
maintain
thermal
homeostasis,
leading
physiological
behavioral
changes
such
as
increased
panting,
reduced
feed
intake,
water
consumption.
These
responses
aim
dissipate
heat
but
result
energy
imbalances,
oxidative
stress,
impaired
immune
function.
Green
tea
polyphenols
(GTPs)
mitigate
modulating
pathways,
primarily
scavenging
reactive
oxygen
species
(ROS)
enhancing
antioxidant
defense
mechanisms.
pathways
play
pivotal
role
neutralizing
ROS
generated
during
inflammation,
exposure
electrophilic
compounds.
action
helps
restore
cellular
balance
enhances
overall
mechanisms
converting
harmful
free
radicals
into
less
molecules,
oxygen.
Nuclear
factor
(erythroid-derived
2)-like
2
(Nrf2)
plays
significant
character
activation
of
enzymatic
antioxidants
network.
translocates
nucleus
upon
activation,
binds
response
elements
(AREs)
promoter
regions
target
genes,
upregulates
expression
key
enzymes.
Therefore,
regulation
Nrf2
considered
molecular
marker
mitigating
effects
its
detoxification
enzymes,
protecting
against
damage
inflammation
induced
temperatures.
exploratory
review
summarizes
anti-oxidative
GTPs
poultry.
highlights
cytoprotective
basis
epigallocatechin-3-gallate
(EGCG),
particularly
Nrf2-mediated
which
enhance
systems
protect
damage.
Язык: Английский
Electronic States of Epigallocatechin-3-Gallate in Water and in 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (Sodium Salt) Liposomes
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1084 - 1084
Опубликована: Янв. 27, 2025
In
this
work,
the
spectroscopy
of
epigallocatechin-3-gallate
(EGCG)
and
EGCG
bonded
to
1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol)
(sodium
salt)
(DPPG)
lipid
is
studied
both
experimentally
by
combining
high-resolution
vacuum
ultraviolet
(VUV)
photo-absorption
measurements
in
4.0–9.0
eV
energy
range
theoretical
calculations
using
density
functional
theory
(DFT)
methodology.
There
a
good
agreement
between
experimental
data,
inclusion
solvent
implicitly
explicitly
further
improves
agreement.
For
all
measured
absorption
bands
observed
VUV
spectra
water,
assignments
calculated
electronic
transitions
are
provided.
The
reveal
that
spectrum
DPPG-EGCG
has
an
intense
peak
around
150
nm,
which
accordance
with
it
assigned
electron
transfer
transition
from
resorcinol–pyrogallol
groups
different
smaller
molecule.
Finally,
increase
absorbance
can
be
associated
interaction
molecules.
Язык: Английский
Protection of Green Tea Polyphenols against Neurodegenerative Diseases: Evidence and Possible Mechanisms
Journal of Nutrition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders
Exploration of neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Neurodegenerative
disorders,
including
Alzheimer’s,
Parkinson’s,
Huntington’s,
and
amyotrophic
lateral
sclerosis,
are
among
the
most
significant
health
concerns
worldwide,
characterized
by
neuronal
dysfunction,
oxidative
stress,
neuroinflammation,
protein
misfolding.
Epigallocatechin
gallate,
a
green
tea
polyphenol,
has
been
reported
to
possess
multifaceted
neuroprotective
properties.
It
reduces
stress
through
free
radical
scavenging,
activation
of
antioxidant
enzymes,
stabilization
mitochondrial
function.
also
inhibits
neuroinflammation
modulation
key
signaling
pathways.
suppresses
amyloid-beta
aggregation
in
Alzheimer’s
alpha-synuclein
fibrillation
thus
attenuating
toxic
accumulation.
Its
activity
induction
autophagy
promotion
synaptic
plasticity
supports
survival
However,
low
bioavailability
metabolic
instability
hinder
its
translation
into
clinic.
Strategies
nanoparticle
encapsulation,
structural
modifications,
combination
therapies
being
explored
overcome
these
challenges.
Future
research
could
establish
epigallocatechin
gallate
as
viable
candidate
for
managing
neurodegenerative
disorders.
Язык: Английский
Combination of Epigallocatechin-3-Gallate and Tramiprosate Prevent Accumulation of Intracellular Aβ and Dysfunctional Autophagy–Lysosomal Pathway at Earliest Stage of Transdifferentiation of Mesenchymal Stromal Cells into PSEN1 E280A Cholinergic-like Neurons
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3756 - 3756
Опубликована: Апрель 16, 2025
Familial
Alzheimer’s
disease
(FAD)
caused
by
presenilin
1
(PSEN1)
E280A
induces
the
aberrant
accumulation
of
intracellular
Aβ
(iAβ)
in
cholinergic-like
neurons
(ChLNs).
How
early
iAβ
accumulates
development
ChLNs
is
still
unknown.
Consequently,
timing
appropriate
therapeutic
approaches
against
FAD
unclear.
To
determine
earliest
PSEN1
ChLNs,
flow
cytometry
and
immunofluorescence
microscopy
were
used
to
follow
menstrual
mesenchymal
stromal
cells
(MenSCs)
into
(proliferation
marker
Ki67,
cluster
differentiation
73
(CD73),
neuronal
nuclei
(NeuN)
marker,
choline
acetyl
transferase
(ChAT)),
kinetics
accumulation,
simultaneous
evaluation
other
associated
markers
(e.g.,
DJ-1C106-SO3;
lysosomes;
phosphatidylethanolamine-conjugated
microtubule-associated
protein
1A/1B
light
chain
3,
LC3-II;
cleaved
caspase
3
(CC3))
at
0,
1,
5,
7
days.
reverse
phenotype,
we
rapamycin
(RAP),
verubecestat
(VER),
compound
E
(CE),
epigallocatechin-3-gallate
(EGCG),
tramiprosate
(TM)
WT
mutant
ChLNs.
We
found
that
did
not
induce
significant
differences
NeuN
ChAT
MenSCs
transitioning
The
cholinergic
developmental
stage
from
day
0
(18%,
stage)
(46%,
stage),
i.e.,
increased
+156%
compared
(1–6%).
A
increase
DJ-1C106-SO3
occurs
only
(+250%).
While
neither
CC3
(0–1%)
nor
lysosomes
different
between
any
time
point,
a
stepwise
autophagosome
was
observed
(15%)
(79%),
+427%,
cells.
RAP,
VER,
CE
able
completely
reduce
all
E280A-induced
combination
EGCG
TM
more
effective
removing
these
than
alone
Given
this
investigation
based
on
single
blood
sample
E280A,
our
results
should
be
considered
exploratory.
Larger
sizes
are
needed.
Язык: Английский
Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 11, 2024
With
the
passage
of
time,
people
step
toward
old
age
and
become
more
prone
to
several
diseases
associated
with
age.
One
such
is
Alzheimer's
disease
(AD)
which
results
into
neuronal
damage
dementia
progression
The
existing
therapeutics
has
been
hindered
by
various
enkindles
like
less
eminent
between
remote
populations,
affordability
issues
toxicity
profiles.
Moreover,
lack
suitable
therapeutic
option
further
worsens
quality
life
in
older
population.
Developing
an
efficient
intervention
cure
AD
still
a
challenge
for
medical
fraternity.
Recently,
alternative
approaches
attain
attention
researchers
focus
on
plant-based
therapy
mitigating
AD.
In
this
context,
flavonoids
gained
centrality
as
feasible
treatment
modifying
neurological
deficits.
This
review
mainly
focuses
pathological
facets
economic
burden
Furthermore,
we
have
explored
possible
mechanism
preclinical
clinical
aspects
curing
Flavonoids
being
potential
therapeutic,
target
pathogenic
factors
oxidative
stress,
inflammation,
metal
toxicity,
Aβ
accumulation,
modulate
neurotransmission
insulin
signaling.
review,
emphasized
neuroprotective
effects
pathology,
both
experimental
findings.
While
studies
suggest
promising
benefits,
data
remains
limited
inconclusive.
Thus,
high-quality
trials
are
necessary
validate
efficacy
study
aim
promote
therapies
encourage
add
regular
diet
avail
beneficial
preventive
Язык: Английский
Food Functional Factors in Alzheimer’s Disease Intervention: Current Research Progress
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 3998 - 3998
Опубликована: Ноя. 22, 2024
Alzheimer's
disease
(AD)
is
a
complex
multifactorial
neurodegenerative
disease.
With
the
escalating
aging
of
global
population,
societal
burden
this
increasing.
Although
drugs
are
available
for
treatment
AD,
their
efficacy
limited
and
there
remains
no
effective
cure.
Therefore,
identification
safe
prevention
strategies
urgently
needed.
Functional
factors
in
foods
encompass
variety
natural
bioactive
substances
that
show
potential
AD.
However,
current
research
focused
on
use
these
functional
AD
its
initial
stages,
complete
theoretical
application
system
to
be
determined.
An
increasing
number
recent
studies
have
found
such
as
polyphenols,
polysaccharides,
unsaturated
fatty
acids,
melatonin,
caffeine
positive
effects
delaying
progression
improving
cognitive
function.
For
example,
polyphenols
exhibit
antioxidant,
anti-inflammatory,
neuroprotective
effects,
polysaccharides
promote
neuronal
growth
inhibit
inflammation
oxidative
stress.
Additionally,
acids
Aβ
production
Tau
protein
phosphorylation
reduce
neuroinflammation,
melatonin
has
been
shown
protect
nerve
cells
improve
function
by
regulating
mitochondrial
homeostasis
autophagy.
Caffeine
also
damage.
Future
should
further
explore
mechanisms
action
develop
relevant
or
nutritional
supplements
provide
new
support
Язык: Английский
The Potential Role of Polyphenol Supplementation in Preventing and Managing Depression: A Review of Current Research
Life,
Год журнала:
2024,
Номер
14(10), С. 1342 - 1342
Опубликована: Окт. 21, 2024
Depression
is
a
common
mental
illness
that
affects
5%
of
the
adult
population
globally.
The
most
symptoms
depression
are
low
mood,
lack
pleasure
from
different
activities,
poor
concentration,
and
reduced
energy
levels
for
an
extended
period,
it
emotions,
behaviors,
overall
well-being
individual.
complex
pathophysiology
presents
challenges
current
therapeutic
options
involving
biopsychosocial
treatment
plan.
These
treatments
may
have
delayed
onset,
remission
response
rates,
undesirable
side
effects.
Researchers
in
nutrition
food
science
increasingly
addressing
depression,
which
significant
public
health
concern
due
to
association
with
increased
incidence
cardiovascular
diseases
premature
mortality.
Polyphenols
present
our
diet
significantly
impact
prevention
depression.
primary
mechanisms
include
reducing
inflammation
oxidative
stress,
regulating
monoamine
neurotransmitter
levels,
modulating
microbiota-gut-brain
axis
hyperactivity
hypothalamic-pituitary-adrenal
(HPA)
axis.
This
review
summarizes
recent
advances
understanding
effects
dietary
polyphenols
on
explores
underlying
these
benefit
human
health.
It
also
highlights
studies
looking
at
clinical
trials
help
future
researchers
incorporate
substances
into
functional
diets,
nutritional
supplements,
or
adjunctive
therapy
prevent
treat
Язык: Английский