Effect of Diet and Dietary Components on the Composition of the Gut Microbiota

Nutrients, Год журнала: 2021, Номер 13(8), С. 2795 - 2795

Опубликована: Авг. 15, 2021

Diet and dietary components have profound effects on the composition of gut microbiota are among most important contributors to alteration in bacterial flora. This review examines “Western”, “plant-based”, “high-fat”, “medical ketogenic”, “Mediterranean” diets both mice human subjects. We show that specific commonly found “plant-based” diet play a role shifting microbial composition. further evaluates metabolites associated with diet, their systemic inflammation metabolic endotoxemia. Furthermore, associations between diet/dietary altering composition, may lead potential therapeutic targets for type II diabetes, obesity, inflammatory diseases.

Язык: Английский

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Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders

Gastroenterology, Год журнала: 2020, Номер 159(3), С. 849 - 863

Опубликована: Июнь 20, 2020

Язык: Английский

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Intestinal Barrier in Human Health and Disease

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(23), С. 12836 - 12836

Опубликована: Дек. 6, 2021

The intestinal mucosa provides a selective permeable barrier for nutrient absorption and protection from external factors. It consists of epithelial cells, immune cells their secretions. gut microbiota participates in regulating the integrity function homeostatic balance. Pathogens, xenobiotics food can disrupt barrier, promoting systemic inflammation tissue damage. Genetic factors predispose individuals to dysfunction, changes composition are central this process. progressive identification these has led development concept ‘leaky syndrome’ ‘gut dysbiosis’, which underlie relationship between impairment, metabolic diseases autoimmunity. Understanding mechanisms underlying process is an intriguing subject research diagnosis treatment various extraintestinal diseases.

Язык: Английский

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Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

Nutrients, Год журнала: 2021, Номер 13(2), С. 699 - 699

Опубликована: Фев. 22, 2021

The most prevalent diseases of our time, non-communicable (NCDs) (including obesity, type 2 diabetes, cardiovascular and some types cancer) are rising worldwide. All them share the condition an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have common malnutrition related to physiopathology. In this context, diet is greatest modulator system–microbiota crosstalk, much interest, new challenges, arising area precision nutrition as a way towards treatment prevention. It fact that westernized (WD) partly responsible for increased prevalence NCDs, negatively affecting both microbiota system. Conversely, other nutritional approaches, such Mediterranean (MD), positively influence system microbiota, proposed not only potential tool clinical management different disease conditions, but prevention health promotion globally. Thus, purpose review determine regulatory role components WD MD interplay, order understand, create awareness of, over key components.

Язык: Английский

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The links between gut microbiota and obesity and obesity related diseases

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 147, С. 112678 - 112678

Опубликована: Фев. 5, 2022

The obesity epidemic has become a global public health crisis in recent years and is continuing to worsen at an alarming rate. However, the pathophysiological mechanisms involved development of obesity-related diseases are still being unraveled. In past ten years, gut microbiota been identified as crucial player affecting onset progression diseases, especially with respect changes its composition metabolites during progression. Herein, we summarize roles microbiota’s metabolite play related diseases. Furthermore, discuss potential therapeutic treatments that can be used modulate microbiome target relevant metabolic pathways

Язык: Английский

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Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Gut Microbes, Год журнала: 2021, Номер 13(1)

Опубликована: Янв. 1, 2021

The gut bacterium

Язык: Английский

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Neuroactive compounds in foods: Occurrence, mechanism and potential health effects

Food Research International, Год журнала: 2019, Номер 128, С. 108744 - 108744

Опубликована: Ноя. 2, 2019

Язык: Английский

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Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Nutrients, Год журнала: 2020, Номер 12(9), С. 2499 - 2499

Опубликована: Авг. 19, 2020

Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries traditional Asian medicine, and nowadays it is widely food as dietary spice worldwide. It received considerable attention its pharmacological activities, which appear to act primarily through anti-inflammatory antioxidant mechanisms. For this reason, proposed tool management many diseases, among are gastrointestinal neurological diabetes, several types cancer. However, pharmacology curcumin remains be elucidated; indeed, discrepancy exists between well-documented vitro vivo activities poor bioavailability chemical instability that should limit any therapeutic effect. Recently, hypothesized could exert direct regulative effects tract, where high concentrations have detected after oral administration. Consequently, might directly exerts regulatory on gut microbiota, thus explaining paradox low systemic wide activities. well known microbiota important roles human physiology, composition can influenced by multitude environmental lifestyle factors. Accordingly, perturbations microbiome profile or dysbiosis key role disease progression. Interestingly, metabolites shown influence microbiota. worth noting from interaction two different phenomena arise: regulation intestinal microflora biotransformation both them potentially crucial activity. This review summarizes most recent studies topic, highlighting strong connection with final aim adding new insight into potential mechanisms effects.

Язык: Английский

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Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics

Frontiers in Nutrition, Год журнала: 2022, Номер 8

Опубликована: Янв. 3, 2022

The human gastrointestinal tract harbours a complex microbial community, which interacts with the mucosal immune system closely. Gut microbiota plays significant role in maintaining host health, could supply various nutrients, regulate energy balance, modulate response, and defence against pathogens. Therefore, favourable equilibrium of gut through modulating bacteria composition, diversity, their activity is beneficial to health. Several studies have shown that probiotics pre-biotics directly indirectly response. In addition, post-biotics, such as bioactive metabolites, produced by microbiota, and/or cell-wall components released probiotics, also been inhibit pathogen growth, maintain an This review summarises concerning impact pre-biotics, post-biotics on systems describes underlying mechanisms effects these substances. Finally, future challenges are proposed.

Язык: Английский

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The interaction among gut microbes, the intestinal barrier and short chain fatty acids

Animal nutrition, Год журнала: 2021, Номер 9, С. 159 - 174

Опубликована: Ноя. 11, 2021

The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves stable symbiotic environment through interdependence, coordination, reciprocal constraints participation an immune response. interaction between microbiota essential for maintaining achieving homeostasis of organism. Consequently, pivotal safeguarding growth development potential productive performance host. As metabolites microorganisms, short chain fatty acids are not only preferred energy metabolic feedstock intestinal epithelial cells, but also exert vital effects on antioxidants regulation community homeostasis. Herein, we summarize microorganisms mechanisms action four barriers organism, will shed light manipulation to achieve precise nutrition specific individuals provide novel perspective prevention treatment diseases.

Язык: Английский

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