International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(18), С. 6732 - 6732
Опубликована: Сен. 14, 2020
Sarcopenia
refers
to
a
condition
of
progressive
loss
skeletal
muscle
mass
and
function
associated
with
higher
risk
falls
fractures
in
older
adults.
Musculoskeletal
aging
leads
reduced
strength,
affecting
the
quality
life
elderly
people.
In
recent
years,
several
studies
contributed
improve
knowledge
pathophysiological
alterations
that
lead
dysfunction;
however,
molecular
mechanisms
underlying
sarcopenia
are
still
not
fully
understood.
Muscle
development
homeostasis
require
fine
gene
expression
modulation
by
which
microRNAs
(miRNAs)
play
crucial
role.
miRNAs
modulate
key
steps
myogenesis
including
satellite
cells
renewal,
plasticity,
regeneration.
Here,
we
provide
an
overview
general
aspects
regeneration
role
plasticity
special
interest
their
adaptation
exercise
elderly.
Annual Review of Animal Biosciences,
Год журнала:
2023,
Номер
12(1), С. 345 - 368
Опубликована: Ноя. 14, 2023
Cultured
meat
is
an
emerging
biotechnology
that
aims
to
produce
from
animal
cell
culture,
rather
than
the
raising
and
slaughtering
of
livestock,
on
environmental
welfare
grounds.
The
detailed
understanding
accurate
manipulation
biology
are
critical
design
cultured
bioprocesses.
Recent
years
have
seen
significant
interest
in
this
field,
with
numerous
scientific
commercial
breakthroughs.
Nevertheless,
these
technologies
remain
at
a
nascent
stage,
myriad
challenges
remain,
spanning
entire
bioprocess.
From
biological
perspective,
include
identification
suitable
starting
types,
tuning
proliferation
differentiation
conditions,
optimization
cell–biomaterial
interactions
create
nutritious,
enticing
foods.
Here,
we
discuss
key
advances
outstanding
meat,
particular
focus
biology,
argue
solving
remaining
bottlenecks
cost-effective,
scalable
fashion
will
require
coordinated,
concerted
efforts.
Success
also
solutions
nonscientific
challenges,
including
regulatory
approval,
consumer
acceptance,
market
feasibility.
However,
if
can
be
overcome,
revolutionize
our
approach
food.
Adolescent
Idiopathic
Scoliosis
(AIS)
is
a
common
pediatric
skeletal
disease
highly
occurred
in
females.
The
pathogenesis
of
AIS
has
not
been
fully
elucidated.
Here,
we
reveal
that
ESR1
(Estrogen
Receptor
1)
expression
declines
muscle
stem/progenitor
cells
at
the
concave
side
patients.
Furthermore,
required
for
cell
differentiation
and
disrupted
signaling
leads
to
defects.
imbalance
para-spinal
muscles
induces
scoliosis
mice,
while
reactivation
by
an
FDA
approved
drug
Raloxifene
alleviates
curve
progression.
This
work
reveals
asymmetric
inactivation
one
causes
AIS.
Reactivation
could
be
new
strategy
treat
Cells,
Год журнала:
2020,
Номер
9(9), С. 2005 - 2005
Опубликована: Сен. 1, 2020
In
this
study,
we
investigated
the
effects
and
mechanisms
of
pro-inflammatory
cytokines
IL-1β
TNF-α
on
proliferation
commitment
phases
myoblast
differentiation.
C2C12
mouse
cells
were
cultured
to
reach
a
proliferated
or
committed
status
incubated
with
these
for
evaluation
cell
proliferation,
cyclooxygenase
2
(COX-2)
expression,
release
prostaglandins
(PGs)
myokines,
activation
myogenic
regulatory
factors
(MRFs).
We
found
that
inhibition
IL-6
receptor
reduced
IL-1β-
TNF-α-induced
effect
also
involved
COX-2-derived
PGs.
Both
modulated
myokines
myostatin,
irisin,
osteonectin,
IL-15.
activity
Pax7
in
MyoD
myogenin
at
both
proliferative
stages.
Otherwise,
increased
only
cells.
Our
data
reveal
key
role
PGs
support
link
between
MRFs.
concluded
induce
similar
initial
stages
muscle
regeneration
but
critical
differences
their
progression
process,
bringing
new
insights
into
inflammatory
signalling
skeletal
regeneration.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(19), С. 10867 - 10867
Опубликована: Окт. 8, 2021
In
severe
muscle
injury,
skeletal
tissue
structure
and
functionality
can
be
repaired
through
the
involvement
of
several
cell
types,
such
as
stem
cells,
innate
immune
responses.
However,
exact
mechanisms
behind
regeneration,
homeostasis,
plasticity
are
still
under
investigation,
discovery
pathways
types
involved
in
repair
open
way
for
novel
therapeutic
approaches,
cell-based
therapies
involving
cells
peripheral
blood
mononucleate
cells.
Indeed,
infusions
a
new
therapy
healing,
likely
because
autologous
infusion
at
site
injury
might
enhance
responses,
especially
those
driven
by
macrophages.
this
review,
we
summarize
current
knowledge
on
functions
macrophages
repairs
their
roles
components
promising
regeneration.
Cells,
Год журнала:
2021,
Номер
10(12), С. 3322 - 3322
Опубликована: Ноя. 26, 2021
In
the
last
decade,
sequence-specific
transcription
factor
double
homeobox
4
(DUX4)
has
gone
from
being
an
obscure
entity
to
a
key
in
important
physiological
and
pathological
processes.
We
now
know
that
expression
of
DUX4
is
highly
regulated
restricted
early
steps
embryonic
development,
where
involved
transcriptional
activation
zygotic
genome.
While
epigenetically
silenced
most
somatic
tissues
healthy
humans,
its
aberrant
reactivation
associated
with
several
diseases,
including
cancer,
viral
infection
facioscapulohumeral
muscular
dystrophy
(FSHD).
also
translocated,
giving
rise
chimeric
oncogenic
proteins
at
basis
sarcoma
leukemia
forms.
Hence,
understanding
how
performs
activity
could
provide
relevant
information,
not
only
further
our
knowledge
human
development
regulation,
but
develop
therapeutic
approaches
for
diseases
DUX4.
Here,
we
summarize
current
on
cellular
molecular
processes
by
special
emphasis
FSHD
dystrophy.
Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Май 30, 2023
Progressive
muscle
weakness
and
degeneration
characterize
Duchenne
muscular
dystrophy
(DMD),
a
lethal,
x-linked
neuromuscular
disorder
that
affects
1
in
5,000
boys.
Loss
of
dystrophin
protein
leads
to
recurrent
degeneration,
progressive
fibrosis,
chronic
inflammation,
dysfunction
skeletal
resident
stem
cells,
called
satellite
cells.
Unfortunately,
there
is
currently
no
cure
for
DMD.
In
this
mini
review,
we
discuss
how
cells
dystrophic
are
functionally
impaired,
contributes
the
DMD
pathology,
tremendous
potential
restoring
endogenous
cell
function
as
viable
treatment
strategy
treat
debilitating
fatal
disease.
