Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 4, 2023
Abstract
Background
Although
compelling
evidences
suggest
that
cortical
spreading
depression
and
the
trigeminovascular
system
activation
are
main
mechanisms
underlying
migraigenesis,
it
remains
“a
nearly
complete
mystery
of
how
migraine
starts”.
Direct
evidence
choroid
plexus
structures
involved
in
presumed
peripheral-central
interaction
is
exceptionally
scarce
and,
thus,
which
demands
further
attention.
Objectives
Our
objective
to
assess
volumetric
changes
quantitatively
episodic
chronic
patients
versus
age
sex
compared
normal
controls,
elucidate
pathophysiology.
Methods
Total
sixty-five
participants
including
18
patients,
16
31
controls
were
recruited
underwent
a
brain
MR
examination
with
3.0T
strength
between
September
2021
May
2023.
The
ventricles
was
segmented
fully
automatically
on
T1-weighted
MRI
sequences
using
FreeSurfer
(Version
5.3.0)
software.
Lateral
ventricular
volume
expressed
as
ratio
ipsilateral
lateral
ventricle
(CP/LV).
Group
differences
assessed
cross-sectionally.
accuracy
CP/LV
for
prediction
receiver
operating
characteristic
curves
analysis.
Results
Patients
more
anxious
depressive,
heavier
headache
burden
impaired
cognitive
ability.
Statistical
analysis
revealed
group
right
side.
ration
decreased
but
size
increased
prolongation
disease
duration.
side
able
differentiate
from
area
under
ROC
curve
(AUC)
0.696
(95%
CI:
0.550–0.818,
sensitivity
100%,
specificity
46.8%,
cut-off
value
0.0741,
P
<
0.05).
diagnostic
efficacy
marginally
higher
distinguishing
AUC
0.715(95%
0.536–0.856,
50%,
94.4%
0.0725,
Conclusion
finding
suggested
dynamic
alteration
pathogenesis
migraine.
associated
can
be
used
potential
imaging
biomarker
diagnosis.
Fluids and Barriers of the CNS,
Год журнала:
2024,
Номер
21(1)
Опубликована: Янв. 24, 2024
Abstract
The
Hindbrain
Choroid
Plexus
is
a
complex,
cerebrospinal
fluid-secreting
tissue
that
projects
into
the
4th
vertebrate
brain
ventricle.
Despite
its
irreplaceability
in
development
and
homeostasis
of
entire
central
nervous
system,
research
other
Plexuses
has
been
neglected
by
neuroscientists
for
decades.
One
obstacles
lack
tools
describe
complex
shape
context
ventricles.
Here
we
introduce
an
effective
tool,
termed
Ch
O
P-CT,
noninvasive,
X-ray
micro-computed
tomography-based,
three-dimensional
visualization
subsequent
quantitative
spatial
morphological
analysis
developing
mouse
Plexus.
P-CT
can
reliably
quantify
volume,
surface
area,
length,
outgrowth
angle,
proportion
ventricular
space
occupied,
asymmetries
general
alterations
embryos
from
embryonic
day
13.5
onwards.
We
provide
evidence
suitable
unbiased
evaluation
detection
within
various
mutant
embryos.
believe,
thanks
to
versatility,
nature
possibility
automation,
will
facilitate
models.
This
ultimately
accelerate
screening
candidate
genes
mechanisms
involved
onset
Plexus-related
diseases.
Folia Morphologica,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 25, 2024
The
anatomical
terms
plexus
chor(i)oideus
(CP)
and
tela
chor(i)oidea
(TC)
are
listed
without
explanations
in
the
official
nomenclature
handbooks
Terminologia
Neuroanatomica
Nomina
Anatomica
Veterinaria.
Definitions
of
CP
TC
exhibit
discrepancies
medical
dictionaries
anatomy
handbooks.
aim
our
study
was
to
analyse
this
problem
detail
discuss
a
possible
unified
use
science
teaching.
We
conducted
systematic
literature
review
based
on
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses,
identifying
analysing
relevant
scholarly
articles.
Additionally,
comprehensive
original
human
veterinary
English
other
European
languages
were
examined.
definitions
differed
considerably
between
articles
did
not
match
most
frequently
given
In
general
use,
it
seems
have
become
accepted
that
represents
smooth,
thin
part
roof
third
fourth
ventricles,
frond-
or
fringe-like
vascularised
structures
invaginated
into
lateral,
ventricles.
However,
is
controversial
which
tissue
layers
should
be
included
their
description.
Etymologically,
only
vascular
network
termed
(choroid)
plexus,
but
embryologically
functionally,
epithelium,
pial
connective
form
an
inseparable
entity.
Similarly,
smooth
ventricle
consists
(less)
pia-derived
stroma
lining
epithelium.
Including
all
these
as
well
definition
might
advisable
also
corresponds
clinical
context.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 4, 2023
Abstract
Background
Although
compelling
evidences
suggest
that
cortical
spreading
depression
and
the
trigeminovascular
system
activation
are
main
mechanisms
underlying
migraigenesis,
it
remains
“a
nearly
complete
mystery
of
how
migraine
starts”.
Direct
evidence
choroid
plexus
structures
involved
in
presumed
peripheral-central
interaction
is
exceptionally
scarce
and,
thus,
which
demands
further
attention.
Objectives
Our
objective
to
assess
volumetric
changes
quantitatively
episodic
chronic
patients
versus
age
sex
compared
normal
controls,
elucidate
pathophysiology.
Methods
Total
sixty-five
participants
including
18
patients,
16
31
controls
were
recruited
underwent
a
brain
MR
examination
with
3.0T
strength
between
September
2021
May
2023.
The
ventricles
was
segmented
fully
automatically
on
T1-weighted
MRI
sequences
using
FreeSurfer
(Version
5.3.0)
software.
Lateral
ventricular
volume
expressed
as
ratio
ipsilateral
lateral
ventricle
(CP/LV).
Group
differences
assessed
cross-sectionally.
accuracy
CP/LV
for
prediction
receiver
operating
characteristic
curves
analysis.
Results
Patients
more
anxious
depressive,
heavier
headache
burden
impaired
cognitive
ability.
Statistical
analysis
revealed
group
right
side.
ration
decreased
but
size
increased
prolongation
disease
duration.
side
able
differentiate
from
area
under
ROC
curve
(AUC)
0.696
(95%
CI:
0.550–0.818,
sensitivity
100%,
specificity
46.8%,
cut-off
value
0.0741,
P
<
0.05).
diagnostic
efficacy
marginally
higher
distinguishing
AUC
0.715(95%
0.536–0.856,
50%,
94.4%
0.0725,
Conclusion
finding
suggested
dynamic
alteration
pathogenesis
migraine.
associated
can
be
used
potential
imaging
biomarker
diagnosis.
