Altered Choroid Plexus Volume and Association with Migraine Pathophysiology DOI Creative Commons

Jianmei Xiong,

Mengqi Liu,

Huanbo Liu

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Abstract Background Although compelling evidences suggest that cortical spreading depression and the trigeminovascular system activation are main mechanisms underlying migraigenesis, it remains “a nearly complete mystery of how migraine starts”. Direct evidence choroid plexus structures involved in presumed peripheral-central interaction is exceptionally scarce and, thus, which demands further attention. Objectives Our objective to assess volumetric changes quantitatively episodic chronic patients versus age sex compared normal controls, elucidate pathophysiology. Methods Total sixty-five participants including 18 patients, 16 31 controls were recruited underwent a brain MR examination with 3.0T strength between September 2021 May 2023. The ventricles was segmented fully automatically on T1-weighted MRI sequences using FreeSurfer (Version 5.3.0) software. Lateral ventricular volume expressed as ratio ipsilateral lateral ventricle (CP/LV). Group differences assessed cross-sectionally. accuracy CP/LV for prediction receiver operating characteristic curves analysis. Results Patients more anxious depressive, heavier headache burden impaired cognitive ability. Statistical analysis revealed group right side. ration decreased but size increased prolongation disease duration. side able differentiate from area under ROC curve (AUC) 0.696 (95% CI: 0.550–0.818, sensitivity 100%, specificity 46.8%, cut-off value 0.0741, P < 0.05). diagnostic efficacy marginally higher distinguishing AUC 0.715(95% 0.536–0.856, 50%, 94.4% 0.0725, Conclusion finding suggested dynamic alteration pathogenesis migraine. associated can be used potential imaging biomarker diagnosis.

Language: Английский

Comparative analysis of meningeal transcriptomes in birds: Potential pathways of resilience to repeated impacts DOI
Abby E. Beatty,

Tara M. Barnes‐Tompkins,

Kira M. Long

et al.

The Anatomical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract The meninges and associated vasculature (MAV) play a crucial role in maintaining cerebral integrity homeostasis. Recent advances transcriptomic analysis have illuminated the significance of MAV understanding complex physiological interactions at interface between skull brain after exposure to mechanical stress. To investigate how responses may confer resilience against repetitive stress, we performed first avian tissues using Downy Woodpecker ( Dryobates pubescens ) Tufted Titmouse Baeolophus bicolor as comparison species. Our findings reveal divergences gene expression profiles related immune response, cellular stress management, protein translation machinery. male woodpeckers exhibit tailored modulation strategy that potentially dampens neuroinflammation while preserving protective immunity. Overrepresented genes involved suggest enhanced mechanisms for mitigating damage promoting repair. Additionally, enrichment translation‐associated pathways hints increased capacity turnover remodeling vital recovery. study not only fills critical gap neurobiology but also lays groundwork research comparative neuroprotection.

Language: Английский

Citations

0
Generation and long-term culture of human cerebellar organoids from pluripotent stem cells DOI
Alexander Atamian, Marcella Birtele, Negar Hosseini

et al.

Nature Protocols, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Language: Английский

Citations

0
Altered Choroid Plexus Volume and Association with Migraine Pathophysiology DOI Creative Commons

Jianmei Xiong,

Mengqi Liu,

Huanbo Liu

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Abstract Background Although compelling evidences suggest that cortical spreading depression and the trigeminovascular system activation are main mechanisms underlying migraigenesis, it remains “a nearly complete mystery of how migraine starts”. Direct evidence choroid plexus structures involved in presumed peripheral-central interaction is exceptionally scarce and, thus, which demands further attention. Objectives Our objective to assess volumetric changes quantitatively episodic chronic patients versus age sex compared normal controls, elucidate pathophysiology. Methods Total sixty-five participants including 18 patients, 16 31 controls were recruited underwent a brain MR examination with 3.0T strength between September 2021 May 2023. The ventricles was segmented fully automatically on T1-weighted MRI sequences using FreeSurfer (Version 5.3.0) software. Lateral ventricular volume expressed as ratio ipsilateral lateral ventricle (CP/LV). Group differences assessed cross-sectionally. accuracy CP/LV for prediction receiver operating characteristic curves analysis. Results Patients more anxious depressive, heavier headache burden impaired cognitive ability. Statistical analysis revealed group right side. ration decreased but size increased prolongation disease duration. side able differentiate from area under ROC curve (AUC) 0.696 (95% CI: 0.550–0.818, sensitivity 100%, specificity 46.8%, cut-off value 0.0741, P < 0.05). diagnostic efficacy marginally higher distinguishing AUC 0.715(95% 0.536–0.856, 50%, 94.4% 0.0725, Conclusion finding suggested dynamic alteration pathogenesis migraine. associated can be used potential imaging biomarker diagnosis.

Language: Английский

Citations

0