Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 18, 2024
Age-related
alterations
in
immune
function
are
believed
to
increase
risk
for
a
host
of
age-related
diseases
leading
premature
death
and
disability.
Programming
the
system
by
diet,
lifestyle,
environmental
factors
occurs
across
lifespan
influences
both
makeup
system,
including
immunometabolism.
This
programming
is
act
large
part
through
epigenetic
modification.
Among
dietary
components
that
affect
this
process,
polyphenols
may
play
an
outsized
role.
Polyphenols
widely
distributed
group
plant
nutrients
consumed
humans.
Certain
foods
possess
distinctive
relatively
higher
levels
these
compounds.
One
such
food
Tartary
buckwheat
(
fagopyrum
tataricum
),
ancient
seed
historically
prized
its
health
benefits.
It
suggested
specific
composition
found
like
lead
unique
impact
on
immunometabolic
physiological
pathways
could
be
interrogated
analyses.
The
objective
study
was
investigate
effects
peripheral
cells
healthy
individuals
standardized
polyphenol
concentrate
based
naturally
occurring
buckwheat.
pilot
clinical
trial
tested
consuming
90
days
50
male
(40%)
female
(60%)
participants
aged
18–85
years
using
age
clocks
deconvolution
methods.
Analysis
revealed
significant
intervention-related
changes
multiple
markers
as
well
population-wide
gene
ontology
(GO)
related
longevity
immunity.
provides
previously
unidentified
insights
into
immune,
consumption
polyphenol-rich
plants
generates
additional
support
interventions
built
around
while
offering
compelling
opportunities
research.
Clinical
registration
ClinicalTrials.gov
,
Identifier:
NCT05234203.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Age-related
alterations
in
immune
function
are
believed
to
increase
risk
for
a
host
of
age-related
diseases
leading
premature
death
and
disability.
Programming
the
system
by
diet,
lifestyle,
environmental
factors
occurs
across
lifespan
influences
both
makeup
system.
This
programming
is
act
large
part
through
epigenetic
modification.
One
group
dietary
molecules
linked
generally
healthier
aging
relative
resilience
homeostasis
polyphenols,
which
consumed
humans
primarily
form
plant
foods.
While
polyphenols
widely
distributed
throughout
fungal
kingdoms,
certain
foods
known
possess
distinctive
relatively
higher
levels
these
compounds.
such
food
Tartary
buckwheat
(
fagopyrum
tataricum
),
an
ancient
seed
historically
prized
its
health
benefits.
It
suggested
that
specific
composition
found
like
may
lead
unique
impact
on
longevity-related
physiological
pathways
could
be
interrogated
analyses.
The
objective
this
study
was
investigate
effects
peripheral
cells
healthy
individuals
standardized
polyphenol
concentrate
based
naturally
occurring
nutrients
buckwheat.
A
pilot
clinical
trial
designed
test
consuming
90
days
cell
methylation
patterns
phenotypes
50
male
(40%)
female
(60%)
participants
aged
18-85
years
using
age
clocks
deconvolution
methods.
Analysis
revealed
significant
intervention-related
changes
multiple
markers
as
well
population-wide
gene
ontology
(GO)
related
longevity
immunity.
provides
previously
unidentified
insights
into
immune,
consumption
polyphenol-rich
plants
generates
additional
support
interventions
built
around
while
offering
compelling
opportunities
research.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 2, 2024
Abstract
Idiopathic
inflammatory
myopathies
(IIM)
are
a
heterogeneous
group
of
muscle
disorders
unknown
etiology.
It
is
postulated
that
mitochondrial
dysfunction
and
protein
aggregation
in
skeletal
contributes
to
myofiber
degeneration.
However,
molecular
pathways
lead
not
well
defined.
Here
we
have
isolated
membrane-bound
organelles
(e.g.,
nuclei,
mitochondria,
endoplasmic
reticulum
(ER),
Golgi
apparatus,
plasma
membrane)
from
biopsies
normal
(n
=
3),
IIM
with
abnormalities
(IIM-mito
10),
myopathy
1)
patients
for
global
proteomic
analysis
using
an
Orbitrap
Fusion
mass
spectrometer.
Upon
unsupervised
clustering,
samples
clustered
separately
IIM-mito
samples.
We
confirmed
previously
known
alterations
identified
several
new
ones.
For
example,
found
differential
expression
(i)
nuclear
proteins
control
cell
division,
transcription,
RNA
regulation,
stability,
(ii)
ER
involved
folding,
degradation,
trafficking
the
cytosol,
(iii)
energy
production/metabolism
cytoskeletal
contractile
machinery
muscle.
Our
data
demonstrate
limited
aggregations
cytosol
(inclusions)
occur
nuclear,
mitochondrial,
membrane
compartments
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 18, 2024
Age-related
alterations
in
immune
function
are
believed
to
increase
risk
for
a
host
of
age-related
diseases
leading
premature
death
and
disability.
Programming
the
system
by
diet,
lifestyle,
environmental
factors
occurs
across
lifespan
influences
both
makeup
system,
including
immunometabolism.
This
programming
is
act
large
part
through
epigenetic
modification.
Among
dietary
components
that
affect
this
process,
polyphenols
may
play
an
outsized
role.
Polyphenols
widely
distributed
group
plant
nutrients
consumed
humans.
Certain
foods
possess
distinctive
relatively
higher
levels
these
compounds.
One
such
food
Tartary
buckwheat
(
fagopyrum
tataricum
),
ancient
seed
historically
prized
its
health
benefits.
It
suggested
specific
composition
found
like
lead
unique
impact
on
immunometabolic
physiological
pathways
could
be
interrogated
analyses.
The
objective
study
was
investigate
effects
peripheral
cells
healthy
individuals
standardized
polyphenol
concentrate
based
naturally
occurring
buckwheat.
pilot
clinical
trial
tested
consuming
90
days
50
male
(40%)
female
(60%)
participants
aged
18–85
years
using
age
clocks
deconvolution
methods.
Analysis
revealed
significant
intervention-related
changes
multiple
markers
as
well
population-wide
gene
ontology
(GO)
related
longevity
immunity.
provides
previously
unidentified
insights
into
immune,
consumption
polyphenol-rich
plants
generates
additional
support
interventions
built
around
while
offering
compelling
opportunities
research.
Clinical
registration
ClinicalTrials.gov
,
Identifier:
NCT05234203.
