The impact of a polyphenol-rich supplement on epigenetic and cellular markers of immune age: a pilot clinical study DOI Creative Commons

A. Perlmutter,

Jeffrey S. Bland,

Arti Chandra

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 18, 2024

Age-related alterations in immune function are believed to increase risk for a host of age-related diseases leading premature death and disability. Programming the system by diet, lifestyle, environmental factors occurs across lifespan influences both makeup system, including immunometabolism. This programming is act large part through epigenetic modification. Among dietary components that affect this process, polyphenols may play an outsized role. Polyphenols widely distributed group plant nutrients consumed humans. Certain foods possess distinctive relatively higher levels these compounds. One such food Tartary buckwheat ( fagopyrum tataricum ), ancient seed historically prized its health benefits. It suggested specific composition found like lead unique impact on immunometabolic physiological pathways could be interrogated analyses. The objective study was investigate effects peripheral cells healthy individuals standardized polyphenol concentrate based naturally occurring buckwheat. pilot clinical trial tested consuming 90 days 50 male (40%) female (60%) participants aged 18–85 years using age clocks deconvolution methods. Analysis revealed significant intervention-related changes multiple markers as well population-wide gene ontology (GO) related longevity immunity. provides previously unidentified insights into immune, consumption polyphenol-rich plants generates additional support interventions built around while offering compelling opportunities research. Clinical registration ClinicalTrials.gov , Identifier: NCT05234203.

Language: Английский

The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age: A Pilot Clinical Study DOI Creative Commons

A. Perlmutter,

Jeffrey S. Bland,

Arti Chandra

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Age-related alterations in immune function are believed to increase risk for a host of age-related diseases leading premature death and disability. Programming the system by diet, lifestyle, environmental factors occurs across lifespan influences both makeup system. This programming is act large part through epigenetic modification. One group dietary molecules linked generally healthier aging relative resilience homeostasis polyphenols, which consumed humans primarily form plant foods. While polyphenols widely distributed throughout fungal kingdoms, certain foods known possess distinctive relatively higher levels these compounds. such food Tartary buckwheat ( fagopyrum tataricum ), an ancient seed historically prized its health benefits. It suggested that specific composition found like may lead unique impact on longevity-related physiological pathways could be interrogated analyses. The objective this study was investigate effects peripheral cells healthy individuals standardized polyphenol concentrate based naturally occurring nutrients buckwheat. A pilot clinical trial designed test consuming 90 days cell methylation patterns phenotypes 50 male (40%) female (60%) participants aged 18-85 years using age clocks deconvolution methods. Analysis revealed significant intervention-related changes multiple markers as well population-wide gene ontology (GO) related longevity immunity. provides previously unidentified insights into immune, consumption polyphenol-rich plants generates additional support interventions built around while offering compelling opportunities research.

Language: Английский

Citations

0
A window into intracellular events in myositis through subcellular proteomics DOI Creative Commons
Jennifer M. Peterson, Valérie Leclair,

Olumide E. Oyebode

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of muscle disorders unknown etiology. It is postulated that mitochondrial dysfunction and protein aggregation in skeletal contributes to myofiber degeneration. However, molecular pathways lead not well defined. Here we have isolated membrane-bound organelles (e.g., nuclei, mitochondria, endoplasmic reticulum (ER), Golgi apparatus, plasma membrane) from biopsies normal (n = 3), IIM with abnormalities (IIM-mito 10), myopathy 1) patients for global proteomic analysis using an Orbitrap Fusion mass spectrometer. Upon unsupervised clustering, samples clustered separately IIM-mito samples. We confirmed previously known alterations identified several new ones. For example, found differential expression (i) nuclear proteins control cell division, transcription, RNA regulation, stability, (ii) ER involved folding, degradation, trafficking the cytosol, (iii) energy production/metabolism cytoskeletal contractile machinery muscle. Our data demonstrate limited aggregations cytosol (inclusions) occur nuclear, mitochondrial, membrane compartments

Language: Английский

Citations

0
The impact of a polyphenol-rich supplement on epigenetic and cellular markers of immune age: a pilot clinical study DOI Creative Commons

A. Perlmutter,

Jeffrey S. Bland,

Arti Chandra

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 18, 2024

Age-related alterations in immune function are believed to increase risk for a host of age-related diseases leading premature death and disability. Programming the system by diet, lifestyle, environmental factors occurs across lifespan influences both makeup system, including immunometabolism. This programming is act large part through epigenetic modification. Among dietary components that affect this process, polyphenols may play an outsized role. Polyphenols widely distributed group plant nutrients consumed humans. Certain foods possess distinctive relatively higher levels these compounds. One such food Tartary buckwheat ( fagopyrum tataricum ), ancient seed historically prized its health benefits. It suggested specific composition found like lead unique impact on immunometabolic physiological pathways could be interrogated analyses. The objective study was investigate effects peripheral cells healthy individuals standardized polyphenol concentrate based naturally occurring buckwheat. pilot clinical trial tested consuming 90 days 50 male (40%) female (60%) participants aged 18–85 years using age clocks deconvolution methods. Analysis revealed significant intervention-related changes multiple markers as well population-wide gene ontology (GO) related longevity immunity. provides previously unidentified insights into immune, consumption polyphenol-rich plants generates additional support interventions built around while offering compelling opportunities research. Clinical registration ClinicalTrials.gov , Identifier: NCT05234203.

Language: Английский

Citations

0