Environmental Pollution, Год журнала: 2024, Номер 364, С. 125321 - 125321
Опубликована: Ноя. 17, 2024
Язык: Английский
Toxicology Reports, Год журнала: 2025, Номер 14, С. 101960 - 101960
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Global Challenges, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
Abstract Viral infections continue to pose a significant challenge global health, with increasing resistance conventional antiviral therapies highlighting the urgent need for alternative treatment strategies. Silver nanoparticles (AgNPs) have attracted attention as broad‐spectrum agents due their unique physicochemical properties and ability target multiple stages of viral infection. This review provides comprehensive analysis mechanisms AgNPs, efficacy against clinically relevant enveloped viruses such influenza, herpes simplex, hepatitis B, coronaviruses. How key nanoparticle characteristics, including size, shape, surface functionalization, synthesis methods, influence performance is examined. Studies indicate that AgNPs exert effects through direct interactions particles, inhibition adhesion, entry into host cells disruption replication. Furthermore, potential applications in therapeutic formulations, coatings, nanomedicine‐based strategies are explored. Despite promise, challenges regarding cytotoxicity, stability, large‐scale production must be addressed ensure safe effective clinical use. highlights transformative therapy further investigation facilitate translation fight emerging drug‐resistant infections.
Язык: Английский
Процитировано
0
Bioconjugate Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Over past decades, a wide range of nanomaterials have been synthesized and exploited to augment the efficacy biocompatibility disease theranostics nanomedicine. The unique physicochemical properties nanomaterials, such as high specific surface area, tunable size shape, versatile chemistry, enable controlled modulation nanomaterial-biosystem interactions and, consequently, more precise interventions, particularly at cellular level. selective nanomaterial-cell can be leveraged regulate internalization, intracellular trafficking localization, clearance enhance therapeutic minimize potential cytotoxicity. Herein, we provide an overview our recent understanding journey modes action in cells. Specifically, highlight various pathways trafficking, excretion these nanomaterials. different especially release delivery, photothermal photodynamic effects, immunomodulation, are also discussed. We conclude review by offering some perspectives on current challenges opportunities this field.
Язык: Английский
Процитировано
0
Next Nanotechnology, Год журнала: 2025, Номер 8, С. 100149 - 100149
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Neurochemistry International, Год журнала: 2024, Номер 178, С. 105801 - 105801
Опубликована: Июль 5, 2024
Язык: Английский
Процитировано
2
Medicina, Год журнала: 2024, Номер 60(10), С. 1682 - 1682
Опубликована: Окт. 14, 2024
Parkinson's disease (PD) is a pathological state characterized by combined set of abnormal movements including slow motion, resting tremors, profound stiffness skeletal muscles, or obvious abnormalities in posture and gait, together with significant behavioral changes. Until now, no single therapeutic modality was able to provide complete cure for PD. This work trial assess the immunomodulatory effects canagliflozin without levodopa/carbidopa on rotenone-induced parkinsonism Balb/c mice.
Язык: Английский
Процитировано
1
Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1567 - 1567
Опубликована: Ноя. 22, 2024
Background/Objectives: The key components of the blood–brain barrier (BBB) are endothelial cells, pericytes, astrocytes, and capillary basement membrane. BBB serves as main for drug delivery to brain is most restrictive in body. Nearly all large therapeutic molecules over 90% small-molecule drugs cannot cross BBB. To overcome this challenge, nanotechnology, particularly systems such nanoparticles (NPs), have gained significant attention. Methods: Poly(lactide-co-glycolide) (PLGA) albumin-based NPs (bovine/human), with or without transferrin (Tf) ligands (BSA, HSA, BSA-Tf, HSA-Tf), nanolipid carriers (NLC) were synthesized. interactions these human microvascular cells (hBMECs), vascular pericytes (hBVPs), astrocytes (hASTROs) analyzed. Results: At doses 15.62 µg/mL, 31.25 62.5 none caused toxic effects on hBMECs, hBVPs, hASTROs after 3 h incubation. All internalized by but BSA-Tf HSA-Tf showed significantly higher uptake hBMECs a dose-dependent manner. Ultrastructural analysis revealed notable differences between NP formulation cell type. Conclusions: Our findings underscore potential ligand-targeted selectively interact cells. reveals distinct cellular processing pathways various formulations across BBB-associated types, autophagy emerging crucial mechanism handling astrocytes. Changes chemical properties upon biological exposure present challenges nanomedicine design, emphasizing need further investigation into at subcellular levels.
Язык: Английский
Процитировано
1
Chemico-Biological Interactions, Год журнала: 2024, Номер unknown, С. 111356 - 111356
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 3, 2024
Abstract Autophagy is a critical cellular pathway for degrading and recycling damaged components, essential maintaining homeostasis. Dysregulation of autophagy contributes to various diseases, including neurodegenerative disorders, cancers, metabolic syndromes, highlighting the therapeutic potential controlled induction. However, current inducers often lack specificity may inadvertently trigger apoptosis, limiting their clinical utility. Here, we present DNA tetrahedron-BH3 peptide nanosystem (Tdpep) engineered selectively induce by disrupting Beclin 1-Bcl2 interaction, pivotal regulatory point in initiation. Tdpep, functionalized with BH3 targeting Bcl2, demonstrated efficient uptake minimal cytotoxicity HeLa cells at concentrations up 200nM. induction was confirmed increased LC3B puncta formation fluorescence intensity comparable that induced rapamycin. flux analysis Tdpep bafilomycin A1 validated enhanced autophagic activity rather than inhibition. Furthermore, treatment significantly reduced ROS levels, indicating effective turnover. Apoptosis assays showed did not confirming its selective also Danio rerio larvae vivo model. Thus, this targeted tetrahedron provides precise modulation platform minimized off-target effects, offering promising strategy diseases associated dysfunction. Graphical abstract
Язык: Английский
Процитировано
0
Environmental Pollution, Год журнала: 2024, Номер 364, С. 125321 - 125321
Опубликована: Ноя. 17, 2024
Язык: Английский
Процитировано
0