When glycobiology meets inflammasome activation: Insights and implications DOI Creative Commons
Hongliang Zhang, Tengchuan Jin, Mengzhou Xue

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Glycobiology focuses mainly on the study of glycan structures and their biological functions. Glycans not only provide a basic energy supply through tricarboxylic acid cycle glycolysis but also serve as important immune regulators during pathogen invasion homeostasis maintenance. Inflammasomes are critical multiprotein complexes system that detect both exogenous pathogenic threats endogenous danger signals to mediate inflammatory responses. has revealed significant insights into mechanisms responses, particularly in context inflammasome activation. This review summarizes multifaceted relationships between glycobiology activation, highlighting how structures, glycosylation patterns, glycan-binding proteins influence pathways. sheds light novel targets for drug development aimed at modulating pathways targeting specific structures. directly or indirectly prime activation inflammasomes, inflammasome-related by modulates downstream inflammation, interaction glycans lectins provides regulatory intersection presents unique opportunity elucidate molecular underlying responses potential therapeutic implications.

Язык: Английский

Targeting inflammasomes as a therapeutic potential for HIV/AIDS DOI Creative Commons
Hongliang Zhang, Botao Tan, Tong B. Tang

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2025, Номер 82(1)

Опубликована: Апрель 17, 2025

Human immunodeficiency virus (HIV) infection in humans can cause a variety of symptoms. Among these, acquired syndrome (AIDS) remains the most severe form. Current treatment HIV/AIDS with antiretroviral drugs effectively inhibits HIV replication and significantly extends lifespan patients. However, cannot completely remove from patients due to high latency HIV, they possess side effects lead drug resistance. be an incurable disease, new methods are still desirable. Inflammasomes were found activated during regulate AIDS progression. Previous reviews provide simple summary inflammasome activators inhibitors without distinguishing specific stage, this kind does not any clinical target value. Here, we comprehensive review inflammasomes according timeline propose several strategies for treatment. We systematacially summarized activation function kinds different stages, aim providing therapeutic targets directions HIV-associated comorbidities.

Язык: Английский

Процитировано

1
When glycobiology meets inflammasome activation: Insights and implications DOI Creative Commons
Hongliang Zhang, Tengchuan Jin, Mengzhou Xue

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Glycobiology focuses mainly on the study of glycan structures and their biological functions. Glycans not only provide a basic energy supply through tricarboxylic acid cycle glycolysis but also serve as important immune regulators during pathogen invasion homeostasis maintenance. Inflammasomes are critical multiprotein complexes system that detect both exogenous pathogenic threats endogenous danger signals to mediate inflammatory responses. has revealed significant insights into mechanisms responses, particularly in context inflammasome activation. This review summarizes multifaceted relationships between glycobiology activation, highlighting how structures, glycosylation patterns, glycan-binding proteins influence pathways. sheds light novel targets for drug development aimed at modulating pathways targeting specific structures. directly or indirectly prime activation inflammasomes, inflammasome-related by modulates downstream inflammation, interaction glycans lectins provides regulatory intersection presents unique opportunity elucidate molecular underlying responses potential therapeutic implications.

Язык: Английский

Процитировано

0