When glycobiology meets inflammasome activation: Insights and implications
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Glycobiology
focuses
mainly
on
the
study
of
glycan
structures
and
their
biological
functions.
Glycans
not
only
provide
a
basic
energy
supply
through
tricarboxylic
acid
cycle
glycolysis
but
also
serve
as
important
immune
regulators
during
pathogen
invasion
homeostasis
maintenance.
Inflammasomes
are
critical
multiprotein
complexes
system
that
detect
both
exogenous
pathogenic
threats
endogenous
danger
signals
to
mediate
inflammatory
responses.
has
revealed
significant
insights
into
mechanisms
responses,
particularly
in
context
inflammasome
activation.
This
review
summarizes
multifaceted
relationships
between
glycobiology
activation,
highlighting
how
structures,
glycosylation
patterns,
glycan-binding
proteins
influence
pathways.
sheds
light
novel
targets
for
drug
development
aimed
at
modulating
pathways
targeting
specific
structures.
directly
or
indirectly
prime
activation
inflammasomes,
inflammasome-related
by
modulates
downstream
inflammation,
interaction
glycans
lectins
provides
regulatory
intersection
presents
unique
opportunity
elucidate
molecular
underlying
responses
potential
therapeutic
implications.
Language: Английский
Targeting inflammasomes as a therapeutic potential for HIV/AIDS
Cellular and Molecular Life Sciences,
Journal Year:
2025,
Volume and Issue:
82(1)
Published: April 17, 2025
Human
immunodeficiency
virus
(HIV)
infection
in
humans
can
cause
a
variety
of
symptoms.
Among
these,
acquired
syndrome
(AIDS)
remains
the
most
severe
form.
Current
treatment
HIV/AIDS
with
antiretroviral
drugs
effectively
inhibits
HIV
replication
and
significantly
extends
lifespan
patients.
However,
cannot
completely
remove
from
patients
due
to
high
latency
HIV,
they
possess
side
effects
lead
drug
resistance.
be
an
incurable
disease,
new
methods
are
still
desirable.
Inflammasomes
were
found
activated
during
regulate
AIDS
progression.
Previous
reviews
provide
simple
summary
inflammasome
activators
inhibitors
without
distinguishing
specific
stage,
this
kind
does
not
any
clinical
target
value.
Here,
we
comprehensive
review
inflammasomes
according
timeline
propose
several
strategies
for
treatment.
We
systematacially
summarized
activation
function
kinds
different
stages,
aim
providing
therapeutic
targets
directions
HIV-associated
comorbidities.
Language: Английский