The FASEB Journal,
Год журнала:
2024,
Номер
38(23)
Опубликована: Дек. 4, 2024
Abstract
Malaria
remains
a
significant
global
public
health
problem.
T
follicular
helper
(Tfh)
cells,
subset
of
CD4
+
have
the
capacity
to
regulate
B
plasma
and
antibody
production,
among
other
functions.
Myeloid‐derived
suppressor
cells
(MDSCs)
possess
strong
immunosuppressive
abilities
can
negatively
various
immune
responses.
However,
role
MDSCs
in
inhibiting
Tfh‐cell
responses
during
Plasmodium
infection
unclear.
In
this
study,
we
investigated
regulatory
effect
on
Tfh
cell‐mediated
upon
infection.
We
found
that
numbers
increased
Further
mechanism
study
revealed
MDSC‐derived
Arg‐1
PD‐L1
prevented
cell
proliferation
activation.
Conversely,
addition
nor‐NOHA
or
anti‐PD‐L1
monoclonal
antibodies
enhanced
activation
indicating
inhibitory
was
dependent
PD‐1/PD‐L1.
vivo
depletion
as
well
relieved
symptoms
infected
mice
improved
their
survival
rates.
These
findings
provide
insights
into
further
impairing
humoral
immunity.
Our
provides
new
strategies
for
malaria
prevention
control.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2499 - 2499
Опубликована: Апрель 6, 2025
Background/Objectives:
Immune
checkpoint
inhibitors
(ICIs)
have
transformed
the
treatment
of
patients
with
non-small
cell
lung
cancer
(NSCLC).
Numerous
studies
suggested
that
immune-related
adverse
events
(irAEs)
are
associated
ICI
efficacy
and
can
affect
any
organ
system.
This
study
aims
to
evaluate
prognostic
significance
cutaneous
IrAEs
(cirAEs)
their
impact
on
effectiveness
PD-1/PD-L1
in
real-world
NSCLC
data.
Methods:
We
retrospectively
collected
treated
as
first-
or
second-line
therapy
between
2015
2022
at
a
single
institution.
evaluated
association
cirAEs
efficacy,
measured
by
objective
response
rate
(ORR),
progression-free
survival
(PFS),
overall
(OS).
Kaplan-Meier
curves
were
generated,
log-rank
tests
used
for
testing.
Multivariable
analysis
was
performed
using
Cox
proportional
hazards
regression
models.
Results:
A
total
510
included
analysis,
median
age
62
years
(range
34-85),
75%
males.
CirAEs
grade
observed
139
(27.3%).
Among
assessed
ORR
significantly
higher
those
compared
without
(54.3%
vs.
29.9%,
p
=
0.0001).
At
follow-up
48
months,
PFS
(14.6
4.7
0.0001)
OS
(29
9.2
improved
cirAEs.
Patients
1-2
showed
even
greater
benefits
(PFS:
14.9
0.003;
OS:
30
0.001).
confirmed
development
cirAE
independently
(hazard
ratio
[HR]
0.60,
95%
confidence
interval
[CI]
0.44-0.80,
The
presence
multisystem
≥
2
SOC
irAEs,
including
cirAE,
strongly
correlated
greatest
benefit
from
ICIs
HR:0.51
(95%
CI
0.35-0.74),
0.001.
Conclusions:
supports
could
be
potential
marker
NSCLC.
may
prognose
treatment.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 24, 2025
In
recent
years,
tumor
immunotherapy
has
made
significant
breakthroughs
in
the
treatment
of
malignant
tumors.
However,
individual
differences
efficacy
have
been
observed
clinical
practice.
There
is
increasing
evidence
that
gut
microbial
metabolites
influence
distal
via
gut-liver
axis,
gut-brain
axis
and
gut-breast
a
process
may
involve
modulating
expression
immune
cells
cytokines
microenvironment
(TME).
this
review,
we
systematically
explore
relationship
between
immunotherapy,
examine
corresponding
natural
products
their
mechanisms
action.
The
in-depth
exploration
research
area
will
provide
new
ideas
strategies
to
enhance
mitigate
adverse
effects.
Journal of Lipid Research,
Год журнала:
2025,
Номер
unknown, С. 100793 - 100793
Опубликована: Апрель 1, 2025
Post-translational
lipid
modification
by
palmitoylation
is
a
reversible
process
crucial
for
maintaining
cellular
functionality.
The
palmitoyl
acyltransferase
zinc
finger
Asp-His-His-Cys
motif-containing
5
(ZDHHC5)
has
garnered
significant
attention
due
to
its
roles
in
neurodegenerative
diseases,
oncogenesis,
and
cardiac
function.
ZDHHC5
recognizes
substrates
through
diverse
mechanisms
activity
regulated
multiple
factors.
Highly
expressed
the
brain,
liver
heart,
exerts
regulatory
functions
various
processes
self-regulation
substrate
palmitoylation.
This
review
focuses
on
of
nervous
system
including
circadian
rhythm,
tumor,
metabolism.
Dysfunctions
are
associated
with
several
thereby
highlighting
potential
as
target
novel
therapeutic
strategies
against
neurological,
metabolic,
oncogenesis.
