Myeloid‐derived suppressor cells inhibit responses of T follicular helper cells during experimental Plasmodium yoelii infection DOI

Lengshan Mo,

Cansheng Hong,

Zi-Bin Jiang

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(23)

Published: Dec. 4, 2024

Abstract Malaria remains a significant global public health problem. T follicular helper (Tfh) cells, subset of CD4 + have the capacity to regulate B plasma and antibody production, among other functions. Myeloid‐derived suppressor cells (MDSCs) possess strong immunosuppressive abilities can negatively various immune responses. However, role MDSCs in inhibiting Tfh‐cell responses during Plasmodium infection unclear. In this study, we investigated regulatory effect on Tfh cell‐mediated upon infection. We found that numbers increased Further mechanism study revealed MDSC‐derived Arg‐1 PD‐L1 prevented cell proliferation activation. Conversely, addition nor‐NOHA or anti‐PD‐L1 monoclonal antibodies enhanced activation indicating inhibitory was dependent PD‐1/PD‐L1. vivo depletion as well relieved symptoms infected mice improved their survival rates. These findings provide insights into further impairing humoral immunity. Our provides new strategies for malaria prevention control.

Language: Английский

A comprehensive review of immune checkpoint inhibitors for cancer treatment DOI
Md Aslam Hossain

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113365 - 113365

Published: Oct. 23, 2024

Language: Английский

Citations

9
Rapid and Differential Diagnosis of Sepsis Stages Using an Advanced 3D Plasmonic Bimetallic Alloy Nanoarchitecture‐Based SERS Biosensor Combined with Machine Learning for Multiple Analyte Identification DOI Creative Commons
Woo Hyun Kim, Sungwoo Lee, Myeong Jin Jeon

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Rapid and accurate differential diagnosis of infections, sepsis, septic shock is essential for preventing unnecessary antibiotic overuse improving the chance patient survival. To address this, a 3D gold nanogranule decorated gold‐silver alloy nanopillar (AuNG@Au‐AgNP) based surface‐enhanced Raman scattering (SERS) biosensor developed, capable quantitatively profiling immune‐related soluble proteins (interleukin three receptor, alpha chain: CD123, programmed cell death ligand 1: PD‐L1, human leukocyte antigen–DR isotype: HLA‐DR, chitotriosidase: ChiT) in serum samples. The bimetallic nanoarchitecture, fabricated using anodized aluminum oxide (AAO), features uniform structure with densely packed nanogaps on heads Au‐Ag nanopillars, enabling fast, simple, replicable production. proposed achieves results even low detection limits (4–6 fM) high signal consistency (relative standard deviation (RSD) = 1.79%) within one‐step multi‐analytes identification chip directly loadable chamber. enhance diagnostic performance, support vector machine (SVM) learning algorithm utilized, achieving 95.0% accuracy 95.8% precision classifying healthy controls, infections without shock. This advanced plasmonic nanoarchitecture‐based SERS demonstrates clinical usefulness sepsis severity assessment, providing timely personalized treatment.

Language: Английский

Citations

1
Association Between Cutaneous Immune-Related Adverse Events and Efficacy of Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer DOI Open Access
José M. García, Vanesa Gutiérrez, A. Cantero

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2499 - 2499

Published: April 6, 2025

Background/Objectives: Immune checkpoint inhibitors (ICIs) have transformed the treatment of patients with non-small cell lung cancer (NSCLC). Numerous studies suggested that immune-related adverse events (irAEs) are associated ICI efficacy and can affect any organ system. This study aims to evaluate prognostic significance cutaneous IrAEs (cirAEs) their impact on effectiveness PD-1/PD-L1 in real-world NSCLC data. Methods: We retrospectively collected treated as first- or second-line therapy between 2015 2022 at a single institution. evaluated association cirAEs efficacy, measured by objective response rate (ORR), progression-free survival (PFS), overall (OS). Kaplan-Meier curves were generated, log-rank tests used for testing. Multivariable analysis was performed using Cox proportional hazards regression models. Results: A total 510 included analysis, median age 62 years (range 34-85), 75% males. CirAEs grade observed 139 (27.3%). Among assessed ORR significantly higher those compared without (54.3% vs. 29.9%, p = 0.0001). At follow-up 48 months, PFS (14.6 4.7 0.0001) OS (29 9.2 improved cirAEs. Patients 1-2 showed even greater benefits (PFS: 14.9 0.003; OS: 30 0.001). confirmed development cirAE independently (hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.44-0.80, The presence multisystem ≥ 2 SOC irAEs, including cirAE, strongly correlated greatest benefit from ICIs HR:0.51 (95% CI 0.35-0.74), 0.001. Conclusions: supports could be potential marker NSCLC. may prognose treatment.

Language: Английский

Citations

1
Evaluation of efficacy, safety and underlying mechanism on Traditional Chinese medicine as synergistic agents for cancer immunotherapy: A preclinical systematic review and meta-analysis DOI
Jing Li, Shipeng Fan, Hongxia Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119035 - 119035

Published: Nov. 5, 2024

Language: Английский

Citations

6
Small Molecule Inhibitors Targeting PD-L1, CTLA4, VISTA, TIM-3, and LAG3 for Cancer Immunotherapy (2020-2024) DOI
Binbin Cheng,

Jiaoli Lv,

Yao Xiao

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 283, P. 117141 - 117141

Published: Dec. 5, 2024

Language: Английский

Citations

4
Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products DOI Creative Commons
Dongyang Li, Xingguo Lan,

Linyi Xu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences efficacy have been observed clinical practice. There is increasing evidence that gut microbial metabolites influence distal via gut-liver axis, gut-brain axis and gut-breast a process may involve modulating expression immune cells cytokines microenvironment (TME). this review, we systematically explore relationship between immunotherapy, examine corresponding natural products their mechanisms action. The in-depth exploration research area will provide new ideas strategies to enhance mitigate adverse effects.

Language: Английский

Citations

0
Is it time to revisit the significance of PD-L1 expression in assisting our treatment decisions? DOI
Georgios Papageorgiou, Nikolaos Skouteris,

Maria Grenzelia

et al.

Immunotherapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 5

Published: March 21, 2025

Language: Английский

Citations

0
Mechanisms and Functional Implications of ZDHHC5 in Cellular Physiology and Disease DOI Creative Commons
Huicong Liu,

Shuo Wen,

Chang Xu

et al.

Journal of Lipid Research, Journal Year: 2025, Volume and Issue: unknown, P. 100793 - 100793

Published: April 1, 2025

Post-translational lipid modification by palmitoylation is a reversible process crucial for maintaining cellular functionality. The palmitoyl acyltransferase zinc finger Asp-His-His-Cys motif-containing 5 (ZDHHC5) has garnered significant attention due to its roles in neurodegenerative diseases, oncogenesis, and cardiac function. ZDHHC5 recognizes substrates through diverse mechanisms activity regulated multiple factors. Highly expressed the brain, liver heart, exerts regulatory functions various processes self-regulation substrate palmitoylation. This review focuses on of nervous system including circadian rhythm, tumor, metabolism. Dysfunctions are associated with several thereby highlighting potential as target novel therapeutic strategies against neurological, metabolic, oncogenesis.

Language: Английский

Citations

0
Programmed death-ligand 1 regulates ameloblastoma growth and recurrence DOI Creative Commons
Linzhou Zhang, Hao Lin,

Jiajie Liang

et al.

International Journal of Oral Science, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 16, 2025

Abstract Tumor cell-intrinsic programmed death-ligand 1 (PD-L1) signals mediate tumor initiation, progression and metastasis, but their effects in ameloblastoma (AM) have not been reported. In this comprehensive study, we observed marked upregulation of PD-L1 AM tissues revealed the robust correlation between elevated expression increased growth recurrence rates. Notably, found that overexpression markedly self-renewal capacity promoted tumorigenic processes invasion hTERT + -AM cells, whereas genetic ablation exerted opposing inhibitory effects. By performing high-resolution single-cell profiling thorough immunohistochemical analyses patients, delineated intricate cellular landscape elucidated mechanisms underlying aggressive phenotype unfavorable prognosis these tumors. Our findings cells with upregulated exhibit proliferative potential stem-like attributes undergo partial epithelial‒mesenchymal transition. This phenotypic shift is induced by activation PI3K-AKT-mTOR signaling axis; thus, study a crucial regulatory mechanism fuels recurrence. Importantly, targeted inhibition PD-L1-PI3K-AKT-mTOR axis significantly suppressed patient-derived organoids, highlighting blockade as promising therapeutic approach for AM.

Language: Английский

Citations

0
Targeted protein degradation with small molecules for cancer immunotherapy DOI Creative Commons
Zichao Yang,

Jianwei Xu,

Xixiang Yang

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101058 - 101058

Published: April 1, 2025

Language: Английский

Citations

0