Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 2, 2024

Язык: Английский

---

Mitochondrial metabolic reprogramming in diabetic kidney disease

Cell Death and Disease, Год журнала: 2024, Номер 15(6)

Опубликована: Июнь 24, 2024

Abstract Diabetic kidney disease, known as a glomerular arises from metabolic disorder impairing renal cell function. Mitochondria, crucial organelles, play key role in substance metabolism via oxidative phosphorylation to generate ATP. Cells undergo reprogramming compensatory mechanism fulfill energy needs for survival and growth, attracting scholarly attention recent years. Studies indicate that mitochondrial significantly influences the pathophysiological progression of DKD. Alterations lead abnormal expression signaling molecules activation pathways, inducing stress-related cellular damage, inflammatory responses, apoptosis, autophagy irregularities, culminating fibrosis insufficiency. This review delves into impact on DKD pathogenesis, emphasizing regulation regulators downstream pathways. Therapeutic interventions targeting can potentially delay progression. The findings underscore importance focusing develop safer more effective therapeutic approaches.

Язык: Английский

---

Metabolic reprogramming in septic acute kidney injury: pathogenesis and therapeutic implications

Metabolism, Год журнала: 2024, Номер 158, С. 155974 - 155974

Опубликована: Июль 10, 2024

Язык: Английский

---

Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 4, 2025

Diabetic nephropathy (DN) is one of the major causes end-stage renal disease. This study aimed to explore internal relationship between metabolic processes and autoimmune responses in patients with DN via untargeted metabolomics Olink proteomics. The serum 10 who were diagnosed healthy individuals Animal models used validate characterized genes. Correlation analysis differentially abundant metabolites expressed proteins revealed that SIRT2 might be a key hub linking energy metabolism innate immune responses. KEGG enrichment showed HIF-1 signaling pathway cell carcinoma co-enriched pathways inflammatory response. VEGFA plays vital role these two pathways. ability regulate expression has been demonstrated. In vivo experiments SIRT2, VEGFA, HIF-1α highly kidneys mice diabetic nephropathy. conclusion, our combines proteomics provide valuable insights into synergistic roles disorders DN. data suggest may target affecting processes.

Язык: Английский

---

SGLT2i delays c-Myc-induced HCC progression via targeting mTOR

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер unknown, С. 167805 - 167805

Опубликована: Март 1, 2025

Язык: Английский

---

Metabolomics in diabetic nephropathy: Unveiling novel biomarkers for diagnosis (Review)

Molecular Medicine Reports, Год журнала: 2024, Номер 30(3)

Опубликована: Июль 3, 2024

Diabetic nephropathy (DN) also known as diabetic kidney disease, is a major microvascular complication of diabetes and leading cause end‑stage renal disease (ESRD), which affects the morbidity mortality patients with diabetes. Despite advancements in care, current diagnostic methods, such determination albuminuria estimated glomerular filtration rate, are limited sensitivity specificity, often only identifying damage after considerable morphological changes. The present review discusses potential metabolomics an approach for early detection management DN. Metabolomics study metabolites, small molecules produced by cellular processes, may provide more sensitive specific tool compared traditional methods. For purposes this review, systematic search was conducted on PubMed Google Scholar recent human studies published between 2011 2023 that used diagnosis has demonstrated metabolic biomarkers to ability detect broad spectrum metabolites high specificity allow earlier better DN, potentially reducing progression ESRD. Furthermore, pathway analysis assesses pathophysiological mechanisms underlying On whole, By providing in‑depth understanding alterations associated could significantly improve detection, enable timely interventions reduce healthcare burdens condition.

Язык: Английский

---

Study on the Mechanism of Jieduquyuziyin prescription Improving the Condition of MRL/lpr Mice by Regulating T Cell Metabolic Reprogramming through the AMPK/mTOR Pathway

Journal of Ethnopharmacology, Год журнала: 2025, Номер 345, С. 119584 - 119584

Опубликована: Март 3, 2025

Язык: Английский

---

Effect of dapagliflozin on the serum metabolome in patients with type 2 diabetes mellitus

Journal of Diabetes & Metabolic Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 16, 2024

Язык: Английский

---