Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 322 - 322
Опубликована: Фев. 21, 2025
Biofilms
are
the
predominant
lifeforms
of
microorganisms,
contributing
to
over
80%
infections,
including
those
caused
by
Candida
species
like
C.
albicans,
parapsilosis
and
Candidozyma
auris.
These
form
biofilms
on
medical
devices,
making
infections
challenging
treat,
especially
with
rise
in
drug-resistant
strains.
particularly
hospital-acquired
ones,
a
significant
health
threat
due
their
resistance
antifungals
risk
developing
systemic
(i.e.,
sepsis).
We
have
previously
shown
that
C14R
reduces
viability
albicans
auris,
but
not
parapsilosis.
Here,
we
show
only
inhibits
pore
formation,
resazurin
reduction
assay,
fluorescence-based
permeabilization
it
also
halts
biofilm
maturation
significantly
biomass
preformed
70%.
findings
suggest
could
be
an
effective
option
for
treating
severe
fungal
offering
potential
new
treatment
approach
biofilm-related
diseases.
Further
research
is
needed
fully
understand
its
dispersal
optimize
use
future
applications
as
antifungal
clinical
settings.
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
The
current
antibacterial
strategies
focus
on
antibiotic
therapy
and
extensive
hygienic
measures
during
orthopedic
surgery.
However,
potential
development
of
implant-associated
infections
remains
a
persistent
clinical
challenge.
There
is,
therefore,
growing
interest
in
introducing
innovative
safe
for
preventing
combating
biofilm
implants.
Antibacterial
coatings,
particularly,
are
attractive
local
delivery
agents.
We
aim
this
proof-of-concept
study
at
novel
translatable
implant
coating
approach,
focusing
directed
assembly
inverse
non-lamellar
lyotropic
liquid
crystalline
(LLC)
nanostructures
implants
prevention
initial
bacterial
attachment
formation
through
the
widely
used
cationic
colistin
(COL).
On
exposure
dry
lipid
films
deposited
model
to
aqueous
solutions
COL
prepared
different
concentrations,
set
LLC
coatings
based
commercial
distilled
monoglyceride
product
(or
glycerol
monooleate)
were
produced.
In
addition
small-angle
X-ray
scattering
(SAXS)
characterization
investigations,
vitro
studies
conducted
evaluating
antibiofilm
properties
against
Gram-negative
bacteria
Pseudomonas
aeruginosa.
SAXS
analysis
indicated
that
all
samples
bicontinuous
cubic
Pn3m
phases.
Significant
COL's
activity
efficient
protection
adhesion
demonstrated
with
surface
produced
by
using
containing
concentrations
50
500
µg/mL.
serum,
detected
structural
alterations
changes
also
discussed.
This
highlights
implications
self-assemblies
designing
nanostructural
implants,
which
can
prevent
Gels,
Год журнала:
2025,
Номер
11(5), С. 346 - 346
Опубликована: Май 7, 2025
To
address
the
limitations
of
conventional
antibacterial
therapies,
we
developed
an
injectable,
conductive
polyurethane-based
composite
gel
system
for
sustained
root
canal
disinfection.
This
incorporates
piezoelectric
nanoparticles
(n-BaTiO3)
and
segments
(aniline
trimer,
AT)
within
a
polyurethane
matrix,
which
synergistically
interact
with
static
antimicrobial
agent
(n-ZnO)
to
achieve
dynamic,
mechano-responsive
activity.
Under
cyclic
compression
(simulating
mastication),
gels
exhibited
enhanced
electroactivity
via
mechano-electric
coupling
effect,
generating
2-fold
higher
voltage
1.8–1.9×
increase
in
current
compared
non-piezoelectric
controls.
The
dynamic
enabled
superior
long-term
performance,
achieving
92–97%
biofilm
eradication,
significantly
than
n-ZnO-only
(88%).
XPS
UV-vis
spectroscopy
analyses
confirmed
mechano-electrochemically
amplified
reactive
oxygen
species
(ROS)
generation,
contributed
improved
disruption.
ISO-compliant
provides
durable,
load-responsive
disinfection
while
maintaining
good
biocompatibility,
offering
promising
solution
prevent
post-treatment
reinfection.
Future Microbiology,
Год журнала:
2024,
Номер
19(18), С. 1573 - 1585
Опубликована: Окт. 21, 2024
(AB)
is
a
clinically
important
bacterial
pathogen
responsible
for
nosocomial
infections.
The
biofilm-forming
capability
of
these
pathogens
reduces
the
antibiotic
penetration
and
its
efficacy,
thereby
complicating
treatment.
current
work
aims
to
isolate
most
potent
