Phytomedicine, Год журнала: 2024, Номер 136, С. 156358 - 156358
Опубликована: Дек. 30, 2024
Язык: Английский
Molecules, Год журнала: 2024, Номер 30(1), С. 128 - 128
Опубликована: Дек. 31, 2024
Multidrug-resistant (MDR) bacteria are becoming more and common, which presents a serious threat to world health could eventually render many of the antibiotics we currently use useless. The research development innovative antimicrobial tactics that can defeat these hardy infections imperative in light this predicament. Antimicrobial peptides (AMPs), have attracted lot attention due their distinct modes action capacity elude conventional resistance mechanisms, among most promising tactics. As substitute for antibiotics, AMPs varied class naturally occurring compounds target membranes disrupt cellular activities demonstrate broad-spectrum activity. objective study is present thorough summary current knowledge regarding AMP mechanisms against MDR bacteria, including immunological modulation, interactions with microbial membranes, possible synergy used drugs. In addition, define review’s scope include recent developments research, emphasizing innovations’ development, optimization, therapeutic promise. We hope emphasize crucial role will play future therapy by bringing together highlighting issues. also advocate AMPs’ continued as part comprehensive strategy counteract growing antibiotic resistance.
Язык: Английский
Процитировано
4
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15
Опубликована: Фев. 14, 2025
About 71% of healthcare-associated infections are due to antibiotic-resistant bacteria, such as carbapenem-resistant A. baumannii , classified by World Health Organization into a critical priority group pathogens. The antimicrobial resistance profile relies on its ability produce several virulence factors, including biofilm formation. Its adhere and persist surfaces has contributed pathogenicity drug resistance. In this study, the an peptide (a chionodracine-derived named KHS-Cnd) inhibit or reduce formation was investigated example potential strategy counteract caused biofilm-forming To aim, profiles were first analyzed in selected strains, two reference six clinical all with different capability, regardless whether they resistant sensitive. Successively, we bactericidal activity that showed MIC values ranging from 5 10 µM significative antibiofilm tested strains at sub-inhibitory concentrations. fact, KHS-Cnd can hinder inhibition percentage between 65% 10%. Also statistically significant reduction mature 20% 50% observed four out eight strains. impacts various stages formation, surface-associated twitching motilities depending strain. particular, our results only possessed motility strongly impaired treatment; three instead, motility, whose for them evident after 24 h incubation peptide. Moreover, invasion pulmonary cells significantly about 32% treatment 1.25 KHS-Cnd. Finally, when used together ceftazidime/avibactam against it able minimal inhibitory concentration antibiotics needed microorganism growth.
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Апрель 16, 2025
The hybrid FowlTα1 peptide represents a promising biomolecule synthesized from two naturally occurring peptides, namely Fowlicidins (Fowl) and Thymosin α1 (Tα1). This particular exhibits remarkable anti-inflammatory antimicrobial properties demonstrates the capacity to effectively interact with lipopolysaccharide (LPS), while simultaneously inducing minimal cytotoxicity hemolytic repercussions. Despite its potential, high cost of this has limited use. To overcome limitation, present study developed cost-effective biocompatible method for expressing in Pichia pastoris ( P. ). We obtained transgenic strain predicted molecular weight 3.1 kDa. was purified followed by reverse-phase high-performance liquid chromatography (RP-HPLC), yielding 7.2 mg purity 98.2%. Furthermore, physiochemical structural analysis revealed an amphipathic helical configuration that enhances bioactivity. Moreover, LPS-stimulated HD11 macrophages, significantly reduced release nitric oxide (NO), TNF-α, IL-6, IL-1β dose-dependent manner p < 0.05 ) displayed robust activity against Escherichia coli E. compared conventional antibiotic. Overall, results highlighted production potential as novel therapeutic agent antimicrobial, anti-inflammatory, anti-endotoxin applications.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2024, Номер 29(24), С. 5922 - 5922
Опубликована: Дек. 15, 2024
Current agricultural practices face numerous challenges, including declining soil fertility and heavy reliance on chemical inputs. Rhizosphere microbial metabolites have emerged as promising agents for enhancing crop health yield in a sustainable manner. These metabolites, phytohormones, antibiotics, volatile organic compounds, play critical roles promoting plant growth, boosting resistance to pathogens, improving resilience environmental stresses. This review comprehensively outlines the mechanisms through which rhizosphere influence health, traits, functional components, yield. It also discusses potential applications of secondary biofertilizers highlights challenges associated with their production practical use. Measures overcome these are proposed, alongside an exploration future development fertilizer industry. The findings presented here provide scientific basis utilizing enhance sustainability, offering new strategies management. Integrating could lead increased productivity, improved quality, reduced dependence synthetic inputs, thereby supporting more environmentally friendly resilient system.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2024, Номер 136, С. 156358 - 156358
Опубликована: Дек. 30, 2024
Язык: Английский
Процитировано
0