Lycopene as a Therapeutic Agent against Aflatoxin B1-Related Toxicity: Mechanistic Insights and Future Directions

Antioxidants, Год журнала: 2024, Номер 13(4), С. 452 - 452

Опубликована: Апрель 11, 2024

Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity association with spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, cancer. Lycopene, lipid-soluble natural carotenoid, has emerged as potential mitigator deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity, nephrotoxicity, intestinal damage, reproductive impairment. This protective mechanism operates reducing oxidative stress, inflammation, lipid peroxidation, activating mitochondrial apoptotic pathway, facilitating activation biogenesis, endogenous antioxidant system, nuclear factor erythroid 2-related 2 (Nrf2)/kelch-like ECH-associated protein 1 (KEAP1) peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) pathways, well regulating activities cytochrome P450 (CYP450) enzymes. review provides an overview lycopene against exposure-induced underlying molecular mechanisms. Furthermore, it explores profile clinical applications lycopene. The present underscores lycopene’s promising detoxification agent intent to stimulate further research practical utilization in this domain.

Язык: Английский

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Environmental Mycotoxins: A Potential Etiological Factor for Neurodegenerative Diseases?

Toxicology, Год журнала: 2025, Номер 511, С. 154056 - 154056

Опубликована: Янв. 13, 2025

Язык: Английский

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A scoping review on mycotoxin-induced neurotoxicity

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Фев. 17, 2025

Язык: Английский

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Melatonin Alleviates T-2 Toxin-Induced Intestinal Injury by Enhancing Gut Barrier Function and Modulating Microbiota in Weaned Piglets

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

The T-2 toxin, originating from a Fusarium species, is mycotoxin that can adversely affect animal health. Melatonin (MT) natural hormone recognized for its properties reduce inflammation and act as an antioxidant. However, MT's capacity to alleviate intestinal harm toxin remains incompletely explored. Employing postweaning piglets, this research investigates prophylactic impact on toxin-induced enterotoxicity. results indicate MT improved growth performance in piglets exposed toxins while also enhancing barrier function. Such effects probably stem ability colonic oxidative stress inflammation. Further findings suggest these changes are closely associated with MT-induced remodeling of microbiota increase short-chain fatty acid (SCFA) levels the intestine. therefore alleviates damage; gut key process.

Язык: Английский

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The neurotoxicity of trichothecenes T-2 toxin and deoxynivalenol (DON): Current status and future perspectives

Food and Chemical Toxicology, Год журнала: 2020, Номер 145, С. 111676 - 111676

Опубликована: Авг. 14, 2020

Язык: Английский

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Novel colorimetric aptasensor based on unmodified gold nanoparticle and ssDNA for rapid and sensitive detection of T-2 toxin

Food Chemistry, Год журнала: 2021, Номер 348, С. 129128 - 129128

Опубликована: Янв. 19, 2021

Язык: Английский

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A fluorescence aptasensor based on controlled zirconium–based MOFs for the highly sensitive detection of T–2 toxin

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2021, Номер 259, С. 119893 - 119893

Опубликована: Май 4, 2021

Язык: Английский

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Toxic mechanisms of the trichothecenes T-2 toxin and deoxynivalenol on protein synthesis

Food and Chemical Toxicology, Год журнала: 2022, Номер 164, С. 113044 - 113044

Опубликована: Апрель 19, 2022

Язык: Английский

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Double-Enzyme Active Vanadium Nanospheres-Mediated Ratiometric Multicolor Immunosensors for Sensitive Detection of the T-2 Toxin

Analytical Chemistry, Год журнала: 2023, Номер 95(12), С. 5275 - 5284

Опубликована: Март 10, 2023

Owing to its high throughput, simplicity, and rapidity, enzyme-linked immunosorbent assay (ELISA) has attracted much attention in the field of immunoassays. However, traditional ELISA usually affords a single signal readout labeling ability enzyme used is poor, resulting low accuracy limited detection range. Herein, vanadium nanospheres (VNSs)-mediated competitive ratio nanozymes-linked (VNSs-RNLISA) was created for sensitive T-2 toxin (T-2). As key biosensor, VNSs with superoxide dismutase-like peroxidase-like dual-enzyme mimetic activities were synthesized by one-step hydrothermal method, which oxidized 1,1-diphenyl-2-picryl-hydrazyl fading catalyzed 3,3',5,5'-tetramethylbenzidine (TMB) color development. Therefore, could not only be qualitatively measured naked eye but also quantitatively evaluated monitoring absorbance at 450 517 nm wavelengths. Moreover, characterization VNSs-labeled antibody probe showed strong dual-enzymatic activity, excellent stability, affinity [the constant (ka) approximately 1.36 × 108 M-1], can significantly improve sensitivity. The limit VNSs-RNLISA 0.021 ng/mL, 27-fold more than (0.561 ng/mL). Besides, change (Δ450/Δ517) decreased linearly range 0.22-13.17 outperforming single-mode nano-enzyme-linked using TMB factor 1.6 times. Furthermore, successfully identify maize oat samples, recoveries ranging from 84.216 125.371%. Overall, this tactic offered promising platform quick food might broaden application assay.

Язык: Английский

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Downregulation of HSP47 Triggers ER Stress-mediated Apoptosis of Hypertrophic Chondrocytes Contributing to T-2 toxin-induced Cartilage Damage

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 125640 - 125640

Опубликована: Янв. 1, 2025

Язык: Английский

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