Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
263, P. 115247 - 115247
Published: July 13, 2023
The
most
prevalent
contaminated
mycotoxin
in
feed
and
grain
is
T-2
toxin.
toxin's
primary
action
target
the
gut
because
it
main
organ
of
absorption.
toxin
can
cause
intestinal
damage,
but,
few
molecular
mechanisms
have
been
elucidated.
It
important
to
discover
key
pathways
by
which
causes
enterotoxicity.
In
this
research,
IPEC-J2
cells
are
used
as
a
cell
model
investigate
function
MAPK
signaling
pathway
toxin-induced
epithelial
damage.
Throughout
results
functional
impairment
reducing
TJ
proteins
Claudin,
Occludin-1,
ZO-1,
N-cadherin,
CX-43
expression.
significantly
reduced
survival
increased
LDH
release
dose-dependent
way.
induced
oxidative
stress
raising
ROS
MDA
content,
mitochondrial
damage
was
indicated
decline
MMP
an
increase
opening
degree
MPTP.
upregulated
expression
ERK,
P38
JNK,
triggered
pathway.
addition,
caused
inflammation
responses
reflected
levels
inflammation-related
factors
IL-8,
p65,
P-p65
IL-6,
down-regulated
IL-10
level.
Inhibition
JNK
molecule
ease
inflammatory
response.
conclusion,
consequence
activating
molecule,
induced,
impair
cellular
inflammation.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 452 - 452
Published: April 11, 2024
Aflatoxin
(AFT)
contamination
poses
a
significant
global
public
health
and
safety
concern,
prompting
widespread
apprehension.
Of
the
various
AFTs,
aflatoxin
B1
(AFB1)
stands
out
for
its
pronounced
toxicity
association
with
spectrum
of
chronic
ailments,
including
cardiovascular
disease,
neurodegenerative
disorders,
cancer.
Lycopene,
lipid-soluble
natural
carotenoid,
has
emerged
as
potential
mitigator
deleterious
effects
induced
by
AFB1
exposure,
spanning
cardiac
injury,
hepatotoxicity,
nephrotoxicity,
intestinal
damage,
reproductive
impairment.
This
protective
mechanism
operates
reducing
oxidative
stress,
inflammation,
lipid
peroxidation,
activating
mitochondrial
apoptotic
pathway,
facilitating
activation
biogenesis,
endogenous
antioxidant
system,
nuclear
factor
erythroid
2-related
2
(Nrf2)/kelch-like
ECH-associated
protein
1
(KEAP1)
peroxisome
proliferator-activated
receptor-γ
coactivator-1
(PGC-1)
pathways,
well
regulating
activities
cytochrome
P450
(CYP450)
enzymes.
review
provides
an
overview
lycopene
against
exposure-induced
underlying
molecular
mechanisms.
Furthermore,
it
explores
profile
clinical
applications
lycopene.
The
present
underscores
lycopene’s
promising
detoxification
agent
intent
to
stimulate
further
research
practical
utilization
in
this
domain.
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 46 - 46
Published: Jan. 8, 2025
Introduction
Fluimucil,
also
known
as
N-acetylcysteine
(NAC),
has
been
used
a
medicinal
drug
for
treating
Alzheimer’s
and
Parkinson’s
disease.
Recent
research
shown
NAC’s
potential
neuroprotective
agent,
preventing
oxidative
damage
promoting
neurodegenerative
treatment.
This
study
conducted
bibliometric
analysis
of
articles
related
to
NAC
use,
identifying
trends,
current
correlations
between
institutions.
The
findings
can
help
identify
unpublished
guide
future
strategies.
not
only
provides
public
interest
in
but
offers
valuable
insights
research.
Methods
In
this
work,
literature
review
methodology
is
employed
gather
data
from
the
Scopus
database
using
keywords
fluimucil,
nac,
n-acetylcystein,
neuroprotective.
Data
were
analyzed
Biblioshiny
VOSviewer
software
produce
visualizations
maps.
We
quantitative
qualitative
analysis.
Results
trend
found
are
Documents
by
Year,
Author,
Affiliations,
country
or
territory,
funding
sponsor,
Factorial
Map
Of
With
Highest
Contributes,
Subject
Area,
Network
Visualization,
Overlay
visualization
scopus
Vosviewer,
Density
Thematic
Map,
Qualitative
Analysis.
Conclusions
Research
on
effects
(NAC)
fluimucil
several
limitations
strengths.
It
uses
trends
mechanisms
action.
However,
may
be
biased
differ.
significant
research,
particularly
diseases
like
Parkinson
Alzheimer.
contributes
understanding
mechanisms.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
The
T-2
toxin,
originating
from
a
Fusarium
species,
is
mycotoxin
that
can
adversely
affect
animal
health.
Melatonin
(MT)
natural
hormone
recognized
for
its
properties
reduce
inflammation
and
act
as
an
antioxidant.
However,
MT's
capacity
to
alleviate
intestinal
harm
toxin
remains
incompletely
explored.
Employing
postweaning
piglets,
this
research
investigates
prophylactic
impact
on
toxin-induced
enterotoxicity.
results
indicate
MT
improved
growth
performance
in
piglets
exposed
toxins
while
also
enhancing
barrier
function.
Such
effects
probably
stem
ability
colonic
oxidative
stress
inflammation.
Further
findings
suggest
these
changes
are
closely
associated
with
MT-induced
remodeling
of
microbiota
increase
short-chain
fatty
acid
(SCFA)
levels
the
intestine.
therefore
alleviates
damage;
gut
key
process.
