Journal of Biochemical and Molecular Toxicology,
Год журнала:
2023,
Номер
37(10)
Опубликована: Июнь 23, 2023
Acetamiprid
(ACMP)
is
an
extensively
used
neonicotinoid
pesticide
to
control
sucking
and
chewing
insects
known
cause
nontarget
toxicity.
The
present
study
aimed
evaluate
the
ameliorative
potential
of
berberine
(BBR)-a
polyphenolic
alkaloid-
on
ACMP-induced
oxidative
stress,
mitochondrial
dysfunctioning,
structural
changes
in
different
rat
brain
regions.
male
Wistar
rats
were
divided
into
four
groups,
that
is,
control,
BBR-treated
(150
mg/kg
b.wt),
ACMP-exposed
(21.7
b.wt)
BBR
+
ACMP
co-treated;
dosed
intragastrically
for
21
consecutive
days.
Results
biochemical
analysis
showed
significantly
ameliorated
stress
by
decreasing
lipid
peroxidation
protein
oxidation
along
with
a
marked
increase
endogenous
antioxidants
lowered
AChE
activity
Inside
mitochondria,
attenuated
toxic
effects
increasing
complexes.
Findings
polymerase
chain
reaction
also
demonstrated
modulatory
against
ACMP-mediated
downregulation
ND1,
ND2,
COX1,
COX4
subunits
histopathological
ultrastructural
examination
validated
transcriptional
alterations
following
toxicity
exposure
protective
neurotoxicity.
Thus,
indicates
promising
neurotoxicity
via
its
antioxidative
activities.
Poultry Science,
Год журнала:
2023,
Номер
102(4), С. 102487 - 102487
Опубликована: Янв. 9, 2023
Thiacloprid
(TH)
is
a
neonicotinoid
insecticide
employed
in
agriculture
to
protect
fruits
and
vegetables
against
different
insects.
It
showed
deleterious
effects
on
the
general
health
of
non-target
organisms
including
birds
animals,
however,
its
developmental
toxicity
has
yet
be
fully
elucidated.
Chicoric
(CA)
rosmarinic
(RA)
acids
are
polyphenolic
compounds
with
wide
range
beneficial
biological
activities.
In
this
study,
possible
protective
CA
RA
were
investigated
chick
embryos
exposed
ovo
TH
(1µg/egg)
or
without
(100
µg/egg)
co-exposure.
reduced
hatchling
body
weight,
weight/egg
relative
weight
bursa
Fabricius
one-day-old
hatchlings.
Examination
7-day-old
chicks
revealed
decline
feed
intake,
daily
gain,
conversion
ratio
(FCR),
plasma
levels
T3,
T4,
growth
hormone.
Serum
ALT,
AST
activities,
total
cholesterol
significant
elevations.
Hepatic
MDA
was
increased
reduction
SOD
activity
GSH
level
downregulation
liver
GST
gene
expression
pattern.
IgG
IgM
reduced,
various
histopathological
alterations
noticed
liver.
Co-administration
mitigated
toxic
When
both
combined,
they
present
synergistic
effect.
can
used
as
agents
improve
performance
have
hepatoprotective
immunostimulant
newly
hatched
chicks.
Environmental Toxicology and Pharmacology,
Год журнала:
2024,
Номер
unknown, С. 104606 - 104606
Опубликована: Дек. 1, 2024
Neonicotinoid
insecticides
(NNIs)
are
the
fastest-growing
class
in
agricultural
protection.
They
target
nicotinic
acetylcholine
receptors
(nAChR)
pests,
stimulating
nervous
system
at
low
doses
and
causing
paralysis
death
higher
concentrations.
NNIs
used
crop
protection,
seed
treatment,
forestry,
agriculture,
flea
control
domestic
cattle.
Effective
lower
concentrations
offering
long-term
control,
favoured
for
their
systemic
activity.
However,
due
to
water
solubility,
mobility,
moderate
persistence,
easily
contaminate
adjacent
aquatic
environments
via
runoff,
leaching,
or
spray
drift.
While
less
toxic
vertebrates,
widespread
use
poses
threats
terrestrial
organisms,
neurotoxicity,
nephrotoxicity,
cytotoxicity,
genotoxicity,
immunotoxicity,
hepatotoxicity,
endocrine
disruption,
reproductive
malformations.
This
review
synthesizes
research
address
knowledge
gaps
on
environmental
impact
of
proposes
policies
mitigate
harmful
effects
non-target
species.
ACS ES&T Water,
Год журнала:
2024,
Номер
4(1), С. 68 - 78
Опубликована: Янв. 3, 2024
This
study
investigated
the
residual
levels
of
eight
parent
neonicotinoid
insecticides
(p-NEOs)
and
three
NEO
metabolites
(m-NEOs)
in
surface
waters
river–estuary–ocean
systems
on
a
large
geographical
scale
South
China.
Imidacloprid,
thiamethoxam,
acetamiprid,
clothianidin
were
dominant
NEOs
waters.
High
∑NEOs
found
upper
reaches
Guangzhou
section
Pearl
River
(PR_GZ),
indicating
multiple
input
sources
PR_GZ.
Additionally,
decreased
influence
terrestrial
human
activities
was
observed
along
with
flow
direction,
where
order
concentration
PR_GZ
(inland
river,
64.5
ng/L)
>
Estuary
(estuary,
33.9
Xisha
Islands
China
Sea
(SS_XS,
open
sea
area,
27.0
ng/L);
level
Northwestern
(coastal
sea,
49.9
also
higher
than
that
area.
The
estimated
annual
fluxes
released
into
totaled
34.8
±
20.4
tons,
most
which
come
from
basin.
To
best
our
knowledge,
this
is
first
to
assess
concentrations,
distribution,
source
analysis
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Май 2, 2024
Acetamiprid
is
a
class
of
neuroactive
insecticides
widely
used
to
control
insect
pests.
The
current
study
aimed
investigate
the
potential
neuroprotective
effects
luteolin
against
acetamiprid-induced
neurotoxicity
in
rat
cerebral
cortex.
Four
equal
groups
adult
male
rats
(10
each):
control,
acetamiprid
(40
mg/kg
for
28
days),
(50
and
acetamiprid+luteolin
cotreatment
were
used.
was
shown
alter
oxidative
state
by
increasing
oxidant
levels
[nitric
oxide
(NO)
malondialdehyde
(MDA)]
decreasing
antioxidants
[glutathione
(GSH),
glutathione
peroxidase
(GPx),
reductase
(GR),
superoxide
dismutase
(SOD),
catalase-(CAT)],
with
increased
activity
nuclear
factor
erythroid
2-related
2-(Nrf2).
Likewise,
increases
inflammatory
response,
as
evidenced
interleukin-1β
(IL-1β),
tumor
necrosis
factor-α
(TNF-α),
kappa
B-(NF-κB).
In
contrast,
treatment
brought
these
markers
back
close
normal,
showing
that
it
protects
neurocytes
from
damage
neuroinflammation
inflammation.
Luteolin
also
demonstrated
role
via
modulation
acetylcholinesterase
(AChE)
cortex
tissue.
Histopathology
showed
severe
neurodegenerative
changes,
apoptotic
cells
seen
layer,
which
evident
protein
expression
Bax
caspase-3
decreased
Bcl-2
levels.
Histochemistry
confirmed
neuronal
degeneration,
proven
change
neurocyte
colour
brown
black
when
stained
silver
stain.
may
have
effect
biochemical
histopathological
changes
induced
Foods,
Год журнала:
2025,
Номер
14(2), С. 182 - 182
Опубликована: Янв. 9, 2025
The
widespread
use
of
thiamethoxam
has
led
to
pesticide
residues
that
have
sparked
global
concerns
regarding
ecological
and
human
health
risks.
A
pressing
requirement
exists
for
a
detection
method
is
both
swift
sensitive.
Herein,
we
introduced
an
innovative
fluorescence
biosensor
constructed
from
alendronic
acid
(ADA)-modified
upconversion
nanoparticles
(UCNPs)
linked
with
magnetic
(MNPs)
via
aptamer
recognition
the
thiamethoxam.
Through
base
pairing,
thiamethoxam-specific
aptamer-functionalized
MNPs
(apt-MNPs)
were
integrated
complementary
DNA-functionalized
UCNPs
(cDNA-UCNPs)
create
MNPs@UCNPs
biosensor.
Thiamethoxam
specifically
attached
apt-MNPs,
leading
their
separation
cDNA-UCNPs,
which
in
turn
reduction
intensity
at
544
nm
following
by
external
field.
change
(ΔI)
was
directly
correlated
concentration
thiamethoxam,
enabling
quantitative
analysis
pesticide.
With
optimized
parameters,
capable
quantifying
within
span
0.4-102.4
ng·mL-1,
it
achieved
limit
as
minute
0.08
ng·mL-1.
Moreover,
leveraging
properties
MNPs,
assay
duration
could
be
abbreviated
25
min.
research
exhibited
precise
sensing
platform
yielded
promising
results
samples
cucumber,
cabbage,
apple.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 676 - 676
Опубликована: Янв. 15, 2025
Long
non-coding
RNAs
(lncRNAs)
are
emerging
as
critical
regulators
in
honeybee
physiology,
influencing
development,
behavior,
and
stress
responses.
This
study
investigates
the
role
of
lncRNA
LOC113219358
immune
response
neurophysiological
regulation
Apis
mellifera
brains.
Using
RNA
interference
(RNAi)
sequencing
(RNA-seq),
we
demonstrate
that
silencing
lncLOC113219358
significantly
alters
expression
162
mRNA
transcripts,
including
genes
associated
with
detoxification,
energy
metabolism,
neuronal
signaling.
Functional
enrichment
analysis
revealed
involvement
neuropeptide
signaling,
ATP
synthesis,
oxidative
phosphorylation
pathways.
Acetylcholinesterase
(AChE),
Glutathione-S-transferase
(GST)
cytochrome
P450
(CYP450)
activities
were
downregulated
48
h
RNAi
treatment.
Additionally,
pull-down
assays
identified
113
proteins
interacting
lncLOC113219358,
synthase
subunits,
heat
shock
proteins,
major
royal
jelly
suggesting
its
cellular
responses
neural
activity
modulation.
These
findings
provide
mechanistic
insights
into
how
mediates
to
environmental
stressors,
contributing
our
understanding
lncRNA-regulated
functions
pollinators.
Journal of Environmental Exposure Assessment,
Год журнала:
2025,
Номер
4(1)
Опубликована: Фев. 19, 2025
This
perspective
presents
first-hand
research
insights
into
the
pervasive
environmental
distribution
of
neonicotinoid
insecticides
(NEOs)
and
their
consequent
human
exposure.
Our
findings
reveal
widespread
NEO
detection
across
biological
matrices,
indicating
potential
health
risks
highlighting
critical
gaps
in
current
risk
assessment
paradigms.
We
identify
an
urgent
need
for
longitudinal
epidemiological
studies,
particularly
focusing
on
vulnerable
populations,
to
comprehensively
assess
NEO-related
outcomes.
These
scientific
should
inform
evidence-based
policy
reforms
management
strategies
effectively
protect
both
public
integrity.
